6MKE

Crystal Structure of Peptidylprolyl Isomerase from Naegleria fowleri with bound FK506

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0016853	molecular_function	isomerase activity
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0016853	molecular_function	isomerase activity
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0016853	molecular_function	isomerase activity
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0016853	molecular_function	isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue FK5 A 201

Chain	Residue
A	TYR38
A	ALA93
A	TYR94
A	PHE111
A	HOH330
A	HOH373
A	HOH376
A	HOH377
D	FK5201
A	PHE48
A	ASP49
A	ARG54
A	PHE58
A	GLU66
A	VAL67
A	ILE68
A	TRP71

---

site_id	AC2
Number of Residues	18
Details	binding site for residue FK5 B 201

Chain	Residue
B	TYR38
B	PHE48
B	ASP49
B	ARG54
B	PHE58
B	GLU66
B	VAL67
B	ILE68
B	TRP71
B	ALA93
B	TYR94
B	PHE111
B	HOH307
B	HOH309
B	HOH336
B	HOH343
C	ILE99
C	FK5201

---

site_id	AC3
Number of Residues	18
Details	binding site for residue FK5 C 201

Chain	Residue
B	PRO100
B	LEU102
B	FK5201
C	TYR38
C	PHE48
C	ASP49
C	ARG54
C	PHE58
C	VAL67
C	ILE68
C	TRP71
C	ALA93
C	TYR94
C	ILE103
C	PHE111
C	HOH306
C	HOH323
C	HOH342

---

site_id	AC4
Number of Residues	19
Details	binding site for residue FK5 D 201

Chain	Residue
A	PRO100
A	FK5201
D	TYR38
D	PHE48
D	ASP49
D	ARG54
D	PHE58
D	GLU66
D	VAL67
D	ILE68
D	TRP71
D	ALA93
D	TYR94
D	ILE103
D	PHE111
D	HOH319
D	HOH325
D	HOH334
D	HOH347

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