6MKE
Crystal Structure of Peptidylprolyl Isomerase from Naegleria fowleri with bound FK506
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016853 | molecular_function | isomerase activity |
| B | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016853 | molecular_function | isomerase activity |
| C | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016853 | molecular_function | isomerase activity |
| D | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016853 | molecular_function | isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue FK5 A 201 |
| Chain | Residue |
| A | TYR38 |
| A | ALA93 |
| A | TYR94 |
| A | PHE111 |
| A | HOH330 |
| A | HOH373 |
| A | HOH376 |
| A | HOH377 |
| D | FK5201 |
| A | PHE48 |
| A | ASP49 |
| A | ARG54 |
| A | PHE58 |
| A | GLU66 |
| A | VAL67 |
| A | ILE68 |
| A | TRP71 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue FK5 B 201 |
| Chain | Residue |
| B | TYR38 |
| B | PHE48 |
| B | ASP49 |
| B | ARG54 |
| B | PHE58 |
| B | GLU66 |
| B | VAL67 |
| B | ILE68 |
| B | TRP71 |
| B | ALA93 |
| B | TYR94 |
| B | PHE111 |
| B | HOH307 |
| B | HOH309 |
| B | HOH336 |
| B | HOH343 |
| C | ILE99 |
| C | FK5201 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue FK5 C 201 |
| Chain | Residue |
| B | PRO100 |
| B | LEU102 |
| B | FK5201 |
| C | TYR38 |
| C | PHE48 |
| C | ASP49 |
| C | ARG54 |
| C | PHE58 |
| C | VAL67 |
| C | ILE68 |
| C | TRP71 |
| C | ALA93 |
| C | TYR94 |
| C | ILE103 |
| C | PHE111 |
| C | HOH306 |
| C | HOH323 |
| C | HOH342 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue FK5 D 201 |
| Chain | Residue |
| A | PRO100 |
| A | FK5201 |
| D | TYR38 |
| D | PHE48 |
| D | ASP49 |
| D | ARG54 |
| D | PHE58 |
| D | GLU66 |
| D | VAL67 |
| D | ILE68 |
| D | TRP71 |
| D | ALA93 |
| D | TYR94 |
| D | ILE103 |
| D | PHE111 |
| D | HOH319 |
| D | HOH325 |
| D | HOH334 |
| D | HOH347 |
