6MJM

Substrate Free Cytochrome P450 3A5 (CYP3A5)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008401	molecular_function	retinoic acid 4-hydroxylase activity
A	0009822	biological_process	alkaloid catabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046222	biological_process	aflatoxin metabolic process
A	0046872	molecular_function	metal ion binding
A	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
A	0070330	molecular_function	aromatase activity
A	0070989	biological_process	oxidative demethylation
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue HEM A 601

Chain	Residue
A	ARG105
A	VAL369
A	ALA370
A	ARG375
A	PRO433
A	PHE434
A	GLY435
A	ARG439
A	ASN440
A	CYS441
A	ILE442
A	ILE118
A	ALA447
A	MET451
A	HOH729
A	HOH743
A	SER119
A	TRP126
A	ARG130
A	PHE137
A	ALA305
A	GLY306
A	THR309

---

site_id	AC2
Number of Residues	1
Details	binding site for residue GOL A 602

Chain	Residue
A	GOL603

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 603

Chain	Residue
A	VAL50
A	ARG54
A	GOL602

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGtGPRNCIG

Chain	Residue	Details
A	PHE434-GLY443

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS441

---