6MHQ

Structure of connexin-46 intercellular gap junction channel at 3.4 angstrom resolution by cryoEM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007601	biological_process	visual perception
B	0005243	molecular_function	gap junction channel activity
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007601	biological_process	visual perception
C	0005243	molecular_function	gap junction channel activity
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
C	0007601	biological_process	visual perception
D	0005243	molecular_function	gap junction channel activity
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
D	0007601	biological_process	visual perception
E	0005243	molecular_function	gap junction channel activity
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
E	0007601	biological_process	visual perception
F	0005243	molecular_function	gap junction channel activity
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication
F	0007601	biological_process	visual perception
G	0005243	molecular_function	gap junction channel activity
G	0005921	cellular_component	gap junction
G	0005922	cellular_component	connexin complex
G	0007154	biological_process	cell communication
G	0007601	biological_process	visual perception
H	0005243	molecular_function	gap junction channel activity
H	0005921	cellular_component	gap junction
H	0005922	cellular_component	connexin complex
H	0007154	biological_process	cell communication
H	0007601	biological_process	visual perception
I	0005243	molecular_function	gap junction channel activity
I	0005921	cellular_component	gap junction
I	0005922	cellular_component	connexin complex
I	0007154	biological_process	cell communication
I	0007601	biological_process	visual perception
J	0005243	molecular_function	gap junction channel activity
J	0005921	cellular_component	gap junction
J	0005922	cellular_component	connexin complex
J	0007154	biological_process	cell communication
J	0007601	biological_process	visual perception
K	0005243	molecular_function	gap junction channel activity
K	0005921	cellular_component	gap junction
K	0005922	cellular_component	connexin complex
K	0007154	biological_process	cell communication
K	0007601	biological_process	visual perception
L	0005243	molecular_function	gap junction channel activity
L	0005921	cellular_component	gap junction
L	0005922	cellular_component	connexin complex
L	0007154	biological_process	cell communication
L	0007601	biological_process	visual perception

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD

Chain	Residue	Details
A	CYS54-ASP67

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site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cdrw.PCpntVDCFISRP

Chain	Residue	Details
A	CYS178-PRO194

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	960
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	684
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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