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6MHF

Galphai3 co-crystallized with GIV/Girdin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006906biological_processvesicle fusion
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007212biological_processdopamine receptor signaling pathway
A0008016biological_processregulation of heart contraction
A0016239biological_processpositive regulation of macroautophagy
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0019904molecular_functionprotein domain specific binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0032794molecular_functionGTPase activating protein binding
A0032930biological_processpositive regulation of superoxide anion generation
A0042588cellular_componentzymogen granule
A0046039biological_processGTP metabolic process
A0046872molecular_functionmetal ion binding
A0051048biological_processnegative regulation of secretion
A0051301biological_processcell division
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue GDP A 401
ChainResidue
AARG21
ALEU175
AARG176
AARG178
AASN269
ALYS270
AASP272
ALEU273
ACYS325
AALA326
ATHR327
AALA41
AHOH509
AHOH521
AHOH555
AHOH567
AGLU43
ASER44
AGLY45
ALYS46
ASER47
ATHR48
ASER151

site_idAC2
Number of Residues7
Detailsbinding site for residue GOL A 402
ChainResidue
ALEU39
AGLY40
AVAL201
AGLY203
AGLN204
AHOH661
CLEU1682

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CGLY1673
ASER47
AASP150
ALEU175
ATHR181
AASP200
AASN269
AALA326

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:27621449
ChainResidueDetails
CPRO1675

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC/PRKCQ => ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:27621449
ChainResidueDetails
CASN1690

219140

PDB entries from 2024-05-01

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