Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MGR

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor Oxanosine monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0003824	molecular_function	catalytic activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
D	0003824	molecular_function	catalytic activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue JQS A 501

Chain	Residue
A	ALA46
A	GLY336
A	MET355
A	GLY357
A	SER358
A	TYR381
A	GLY383
A	MET384
A	GLY385
A	SER386
A	GLU411
A	ASN273
A	GLY412
A	MPD508
A	HOH613
A	HOH617
A	HOH633
A	HOH654
A	HOH655
A	HOH657
A	GLY298
A	SER299
A	ILE300
A	CYS301
A	THR303
A	ASP334
A	GLY335

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 502

Chain	Residue
A	ARG62
A	LYS201

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 503

Chain	Residue
A	SER245
A	ALA246
A	PHE399
A	GLN400
A	HOH672

site_id	AC4
Number of Residues	3
Details	binding site for residue CL A 504

Chain	Residue
A	THR460
B	THR460
C	THR460

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 505

Chain	Residue
A	GLN226
A	ARG229

site_id	AC6
Number of Residues	1
Details	binding site for residue CL A 506

Chain	Residue
A	SER422

site_id	AC7
Number of Residues	2
Details	binding site for residue CL A 507

Chain	Residue
A	THR38
A	ARG217

site_id	AC8
Number of Residues	3
Details	binding site for residue MPD A 508

Chain	Residue
A	MET384
A	GLN400
A	JQS501

site_id	AC9
Number of Residues	6
Details	binding site for residue K A 509

Chain	Residue
A	GLU465
A	SER466
A	HIS467
D	GLY296
D	GLY298
D	CYS301

site_id	AD1
Number of Residues	6
Details	binding site for residue K B 501

Chain	Residue
A	GLY296
A	GLY298
A	CYS301
B	GLU465
B	SER466
B	HIS467

site_id	AD2
Number of Residues	28
Details	binding site for residue JQS B 502

Chain	Residue
B	ALA46
B	MET48
B	ASN273
B	GLY298
B	SER299
B	ILE300
B	CYS301
B	THR303
B	ASP334
B	GLY335
B	GLY336
B	MET355
B	GLY357
B	SER358
B	TYR381
B	GLY383
B	MET384
B	GLY385
B	SER386
B	GLU411
B	GLY412
B	MPD511
B	HOH617
B	HOH624
B	HOH631
B	HOH656
B	HOH668
B	HOH676

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 B 503

Chain	Residue
B	SER245
B	ALA246
B	TYR398
B	PHE399
B	GLN400
B	HOH671

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 B 504

Chain	Residue
B	HIS54
B	ARG55

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 B 505

Chain	Residue
B	ARG55
B	ARG62

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 B 506

Chain	Residue
B	TYR378
B	ARG416
C	THR472

site_id	AD7
Number of Residues	2
Details	binding site for residue SO4 B 507

Chain	Residue
B	SER425
B	SER422

site_id	AD8
Number of Residues	3
Details	binding site for residue K B 508

Chain	Residue
B	ASP364
B	SER366
B	GLY368

site_id	AD9
Number of Residues	1
Details	binding site for residue SO4 B 509

Chain	Residue
B	ARG84

site_id	AE1
Number of Residues	2
Details	binding site for residue CL B 510

Chain	Residue
B	THR38
B	ARG217

site_id	AE2
Number of Residues	3
Details	binding site for residue MPD B 511

Chain	Residue
B	MET384
B	GLN400
B	JQS502

site_id	AE3
Number of Residues	6
Details	binding site for residue K C 501

Chain	Residue
B	GLY296
B	GLY298
B	CYS301
C	GLU465
C	SER466
C	HIS467

site_id	AE4
Number of Residues	27
Details	binding site for residue JQS C 502

Chain	Residue
C	ALA46
C	ASN273
C	GLY298
C	SER299
C	ILE300
C	CYS301
C	THR303
C	ASP334
C	GLY335
C	GLY336
C	MET355
C	ILE356
C	GLY357
C	SER358
C	TYR381
C	GLY383
C	MET384
C	GLY385
C	SER386
C	GLU411
C	GLY412
C	MPD509
C	HOH618
C	HOH621
C	HOH648
C	HOH652
C	HOH662

site_id	AE5
Number of Residues	7
Details	binding site for residue SO4 C 503

Chain	Residue
C	SER245
C	ALA246
C	ARG397
C	TYR398
C	PHE399
C	GLN400
C	HOH671

site_id	AE6
Number of Residues	1
Details	binding site for residue CL C 504

Chain	Residue
C	ARG229

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 C 505

Chain	Residue
C	TYR378
C	ARG416
D	THR472

site_id	AE8
Number of Residues	1
Details	binding site for residue SO4 C 506

Chain	Residue
C	ARG84

site_id	AE9
Number of Residues	2
Details	binding site for residue SO4 C 507

Chain	Residue
C	ARG62
C	HOH607

site_id	AF1
Number of Residues	1
Details	binding site for residue SO4 C 508

Chain	Residue
C	SER422

site_id	AF2
Number of Residues	3
Details	binding site for residue MPD C 509

Chain	Residue
C	MET384
C	GLN400
C	JQS502

site_id	AF3
Number of Residues	6
Details	binding site for residue K D 501

Chain	Residue
C	GLY296
C	GLY298
C	CYS301
D	GLU465
D	SER466
D	HIS467

site_id	AF4
Number of Residues	28
Details	binding site for residue JQS D 502

Chain	Residue
D	ALA46
D	MET48
D	ASN273
D	GLY298
D	SER299
D	ILE300
D	CYS301
D	THR303
D	ASP334
D	GLY335
D	GLY336
D	MET355
D	GLY357
D	SER358
D	TYR381
D	GLY383
D	MET384
D	GLY385
D	SER386
D	GLU411
D	GLY412
D	HOH603
D	HOH626
D	HOH647
D	HOH648
D	HOH651
D	HOH652
D	HOH675

site_id	AF5
Number of Residues	6
Details	binding site for residue SO4 D 503

Chain	Residue
D	SER245
D	ALA246
D	TYR398
D	PHE399
D	GLN400
D	HOH669

site_id	AF6
Number of Residues	1
Details	binding site for residue SO4 D 504

Chain	Residue
D	HIS54

site_id	AF7
Number of Residues	3
Details	binding site for residue SO4 D 505

Chain	Residue
D	ASN325
D	GLY328
D	VAL329

site_id	AF8
Number of Residues	2
Details	binding site for residue CL D 506

Chain	Residue
D	THR38
D	ARG217

site_id	AF9
Number of Residues	1
Details	binding site for residue CL D 507

Chain	Residue
D	ARG229

site_id	AG1
Number of Residues	2
Details	binding site for residue CL D 508

Chain	Residue
D	ARG62
D	LYS201

site_id	AG2
Number of Residues	1
Details	binding site for residue CL D 509

Chain	Residue
D	SER422

site_id	AG3
Number of Residues	2
Details	binding site for residue SO4 D 510

Chain	Residue
D	ARG80
D	ARG84

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGIGpGSICtT

Chain	Residue	Details
A	VAL291-THR303

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)