6MGG
Succinyl-CoA synthase from Francisella tularensis, phosphorylated, in complex with CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| A | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| B | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006104 | biological_process | succinyl-CoA metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042709 | cellular_component | succinate-CoA ligase complex |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| C | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
| C | 0016874 | molecular_function | ligase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| D | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006104 | biological_process | succinyl-CoA metabolic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0042709 | cellular_component | succinate-CoA ligase complex |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | binding site for residue COA A 501 |
| Chain | Residue |
| A | GLY15 |
| A | VAL73 |
| A | SER81 |
| A | ILE96 |
| A | THR97 |
| A | GLU98 |
| A | ASN123 |
| A | CYS124 |
| A | PRO125 |
| A | ILE137 |
| A | NEP247 |
| A | THR17 |
| A | HOH606 |
| A | HOH618 |
| A | HOH626 |
| A | HOH628 |
| A | HOH632 |
| A | HOH642 |
| A | HOH662 |
| A | HOH665 |
| A | HOH666 |
| A | HOH668 |
| A | GLY18 |
| A | HOH675 |
| A | HOH689 |
| A | HOH707 |
| A | HOH722 |
| A | HOH751 |
| A | HOH753 |
| A | LYS19 |
| A | ASN20 |
| A | VAL39 |
| A | PRO41 |
| A | LYS43 |
| A | TYR72 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | NEP247 |
| A | HOH628 |
| A | HOH636 |
| A | HOH647 |
| A | HOH695 |
| B | HOH545 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 401 |
| Chain | Residue |
| B | MET1 |
| B | ASN2 |
| B | HIS50 |
| B | GLN238 |
| B | GLU239 |
| B | HOH557 |
| B | HOH663 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | LYS147 |
| B | GLU163 |
| B | LYS167 |
| B | HOH660 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue COA C 501 |
| Chain | Residue |
| C | GLY15 |
| C | THR17 |
| C | GLY18 |
| C | LYS19 |
| C | ASN20 |
| C | VAL39 |
| C | PRO41 |
| C | LYS43 |
| C | TYR72 |
| C | VAL73 |
| C | PRO74 |
| C | SER81 |
| C | ILE96 |
| C | THR97 |
| C | GLU98 |
| C | ASN123 |
| C | CYS124 |
| C | PRO125 |
| C | ILE137 |
| C | NEP247 |
| C | HOH607 |
| C | HOH635 |
| C | HOH657 |
| C | HOH668 |
| C | HOH683 |
| C | HOH700 |
| C | HOH706 |
| C | HOH716 |
| C | HOH725 |
| C | HOH750 |
| C | HOH764 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 502 |
| Chain | Residue |
| C | NEP247 |
| C | HOH635 |
| C | HOH645 |
| C | HOH721 |
| C | HOH733 |
| D | HOH662 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 501 |
| Chain | Residue |
| D | LYS147 |
| D | GLU163 |
| D | LYS167 |
| D | HOH701 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| B | SER365 |
| B | GLY366 |
| D | ASN259 |
| D | GLY282 |
| D | LYS283 |
| D | LEU386 |
Functional Information from PROSITE/UniProt
| site_id | PS00399 |
| Number of Residues | 14 |
| Details | SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GvtAppgk...RMGHAG |
| Chain | Residue | Details |
| A | GLY236-GLY249 |
| site_id | PS01216 |
| Number of Residues | 30 |
| Details | SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGTLTyEavaqttklgfGqstcIGIGGD |
| Chain | Residue | Details |
| A | SER152-ASP181 |
| site_id | PS01217 |
| Number of Residues | 26 |
| Details | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GnIgcMvNGAGLAmatmDiIqlygGK |
| Chain | Residue | Details |
| B | GLY258-LYS283 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00558 |
| Chain | Residue | Details |
| B | LYS46 | |
| D | LYS46 | |
| D | GLY53 | |
| D | GLU100 | |
| D | TYR103 | |
| D | GLU108 | |
| D | ASN200 | |
| D | ASP214 | |
| D | ASN265 | |
| D | GLY322 | |
| B | GLY53 | |
| B | GLU100 | |
| B | TYR103 | |
| B | GLU108 | |
| B | ASN200 | |
| B | ASP214 | |
| B | ASN265 | |
| B | GLY322 |
