6MGG

Succinyl-CoA synthase from Francisella tularensis, phosphorylated, in complex with CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
A	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
A	0006099	biological_process	tricarboxylic acid cycle
A	0009361	cellular_component	succinate-CoA ligase complex (ADP-forming)
A	0016874	molecular_function	ligase activity
A	0042709	cellular_component	succinate-CoA ligase complex
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
B	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006099	biological_process	tricarboxylic acid cycle
B	0006104	biological_process	succinyl-CoA metabolic process
B	0016874	molecular_function	ligase activity
B	0042709	cellular_component	succinate-CoA ligase complex
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
C	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
C	0006099	biological_process	tricarboxylic acid cycle
C	0009361	cellular_component	succinate-CoA ligase complex (ADP-forming)
C	0016874	molecular_function	ligase activity
C	0042709	cellular_component	succinate-CoA ligase complex
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
D	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006099	biological_process	tricarboxylic acid cycle
D	0006104	biological_process	succinyl-CoA metabolic process
D	0016874	molecular_function	ligase activity
D	0042709	cellular_component	succinate-CoA ligase complex
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	binding site for residue COA A 501

Chain	Residue
A	GLY15
A	VAL73
A	SER81
A	ILE96
A	THR97
A	GLU98
A	ASN123
A	CYS124
A	PRO125
A	ILE137
A	NEP247
A	THR17
A	HOH606
A	HOH618
A	HOH626
A	HOH628
A	HOH632
A	HOH642
A	HOH662
A	HOH665
A	HOH666
A	HOH668
A	GLY18
A	HOH675
A	HOH689
A	HOH707
A	HOH722
A	HOH751
A	HOH753
A	LYS19
A	ASN20
A	VAL39
A	PRO41
A	LYS43
A	TYR72

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 502

Chain	Residue
A	NEP247
A	HOH628
A	HOH636
A	HOH647
A	HOH695
B	HOH545

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO B 401

Chain	Residue
B	MET1
B	ASN2
B	HIS50
B	GLN238
B	GLU239
B	HOH557
B	HOH663

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO B 402

Chain	Residue
B	LYS147
B	GLU163
B	LYS167
B	HOH660

---

site_id	AC5
Number of Residues	31
Details	binding site for residue COA C 501

Chain	Residue
C	GLY15
C	THR17
C	GLY18
C	LYS19
C	ASN20
C	VAL39
C	PRO41
C	LYS43
C	TYR72
C	VAL73
C	PRO74
C	SER81
C	ILE96
C	THR97
C	GLU98
C	ASN123
C	CYS124
C	PRO125
C	ILE137
C	NEP247
C	HOH607
C	HOH635
C	HOH657
C	HOH668
C	HOH683
C	HOH700
C	HOH706
C	HOH716
C	HOH725
C	HOH750
C	HOH764

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 502

Chain	Residue
C	NEP247
C	HOH635
C	HOH645
C	HOH721
C	HOH733
D	HOH662

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO D 501

Chain	Residue
D	LYS147
D	GLU163
D	LYS167
D	HOH701

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO D 502

Chain	Residue
B	SER365
B	GLY366
D	ASN259
D	GLY282
D	LYS283
D	LEU386

---

Functional Information from PROSITE/UniProt

site_id	PS00399
Number of Residues	14
Details	SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GvtAppgk...RMGHAG

Chain	Residue	Details
A	GLY236-GLY249

---

site_id	PS01216
Number of Residues	30
Details	SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGTLTyEavaqttklgfGqstcIGIGGD

Chain	Residue	Details
A	SER152-ASP181

---

site_id	PS01217
Number of Residues	26
Details	SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GnIgcMvNGAGLAmatmDiIqlygGK

Chain	Residue	Details
B	GLY258-LYS283

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI7
Number of Residues	472
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"HAMAP-Rule","id":"MF_00558","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00558","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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