6MG1

C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2 Crystal Form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO C 101

Chain	Residue
A	ASN281
C	DA11
C	DA12
C	HOH230

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO C 102

Chain	Residue
C	DT1
C	DA2
C	DA14
C	HOH205
D	DA102

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO D 401

Chain	Residue
C	DA2
D	DT101
D	DA102
D	DA114
D	HOH503

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO D 402

Chain	Residue
B	ARG277
B	ASN281
D	DA111
D	DA112
D	HOH526

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL D 403

Chain	Residue
C	DT15
C	DA16
D	DT115
D	DA116

---

site_id	AC6
Number of Residues	14
Details	binding site for Di-nucleotide DG C 7 and 5CM C 8

Chain	Residue
A	ARG289
B	ARG289
C	DT6
C	DG9
C	HOH218
C	HOH220
C	HOH224
C	HOH225
C	HOH226
C	HOH227
D	5CM108
D	DG109
D	5CM110
D	DA111

---

site_id	AC7
Number of Residues	14
Details	binding site for Di-nucleotide 5CM C 8 and DG C 9

Chain	Residue
A	ASN282
A	ARG286
A	ARG289
B	ARG289
C	DG7
C	5CM10
C	HOH216
C	HOH220
C	HOH221
C	HOH225
C	HOH227
D	DG107
D	5CM108
D	DG109

---

site_id	AC8
Number of Residues	14
Details	binding site for Di-nucleotide DG C 9 and 5CM C 10

Chain	Residue
A	ARG278
A	ASN282
A	ARG286
A	ARG289
C	5CM8
C	DA11
C	HOH208
C	HOH212
C	HOH216
C	HOH221
D	DT106
D	DG107
D	5CM108
D	DG109

---

site_id	AC9
Number of Residues	16
Details	binding site for Di-nucleotide 5CM C 10 and DA C 11

Chain	Residue
A	TYR274
A	ARG278
A	ASN281
A	ASN282
A	ARG289
C	DG9
C	DA12
C	EDO101
C	HOH208
C	HOH212
C	HOH216
C	HOH219
C	HOH223
D	DT105
D	DT106
D	DG107

---

site_id	AD1
Number of Residues	14
Details	binding site for Di-nucleotide DG D 107 and 5CM D 108

Chain	Residue
A	ARG289
B	ARG289
B	LYS293
C	5CM8
C	DG9
C	5CM10
C	DA11
D	DT106
D	DG109
D	HOH514
D	HOH515
D	HOH527
D	HOH529
D	HOH530

---

site_id	AD2
Number of Residues	16
Details	binding site for Di-nucleotide 5CM D 108 and DG D 109

Chain	Residue
C	DG7
C	5CM8
C	DG9
D	DG107
D	5CM110
D	HOH509
D	HOH515
D	HOH520
D	HOH527
D	HOH528
D	HOH529
D	HOH531
A	ARG289
B	ASN282
B	ARG286
B	ARG289

---

site_id	AD3
Number of Residues	16
Details	binding site for Di-nucleotide DG D 109 and 5CM D 110

Chain	Residue
B	ARG278
B	ASN282
B	ARG286
B	ARG289
C	DT6
C	DG7
C	5CM8
C	DG9
D	5CM108
D	DA111
D	HOH502
D	HOH509
D	HOH513
D	HOH520
D	HOH528
D	HOH531

---

site_id	AD4
Number of Residues	15
Details	binding site for Di-nucleotide 5CM D 110 and DA D 111

Chain	Residue
B	TYR274
B	ARG278
B	ASN281
B	ASN282
B	ARG289
C	DT5
C	DT6
C	DG7
D	DG109
D	DA112
D	EDO402
D	HOH502
D	HOH513
D	HOH523
D	HOH524

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	126
Details	Domain: {"description":"bZIP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00978","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Region: {"description":"Basic motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00978","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Region: {"description":"Leucine-zipper","evidences":[{"source":"PROSITE-ProRule","id":"PRU00978","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCA","evidences":[{"source":"PubMed","id":"9374525","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CaMK2","evidences":[{"source":"UniProtKB","id":"P28033","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---