6MC1
Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006470 | biological_process | protein dephosphorylation |
A | 0016311 | biological_process | dephosphorylation |
A | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
B | 0006470 | biological_process | protein dephosphorylation |
B | 0016311 | biological_process | dephosphorylation |
B | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
C | 0006470 | biological_process | protein dephosphorylation |
C | 0016311 | biological_process | dephosphorylation |
C | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
D | 0006470 | biological_process | protein dephosphorylation |
D | 0016311 | biological_process | dephosphorylation |
D | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
E | 0006470 | biological_process | protein dephosphorylation |
E | 0016311 | biological_process | dephosphorylation |
E | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
F | 0006470 | biological_process | protein dephosphorylation |
F | 0016311 | biological_process | dephosphorylation |
F | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue CJA A 500 |
Chain | Residue |
A | SER413 |
A | THR417 |
A | MET431 |
A | THR432 |
A | TYR435 |
A | PRO447 |
A | ASN448 |
A | MET452 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue CJA B 500 |
Chain | Residue |
B | TYR435 |
B | ILE445 |
B | SER446 |
B | PRO447 |
B | ASN448 |
B | MET452 |
B | MET431 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue DTT B 501 |
Chain | Residue |
B | ASP377 |
B | ASN379 |
B | PRO447 |
B | LEU449 |
B | ACT502 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ACT B 502 |
Chain | Residue |
B | ASN379 |
B | DTT501 |
C | ASN382 |
C | ARG384 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue CJA C 500 |
Chain | Residue |
C | SER413 |
C | THR417 |
C | TYR435 |
C | SER446 |
C | PRO447 |
C | ASN448 |
C | MET452 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue DTT C 501 |
Chain | Residue |
C | ASP377 |
C | ASN448 |
C | LEU449 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue CJA D 500 |
Chain | Residue |
D | TYR435 |
D | ILE445 |
D | PRO447 |
D | ASN448 |
D | MET452 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue DTT D 501 |
Chain | Residue |
D | LEU449 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue CJA E 500 |
Chain | Residue |
E | SER413 |
E | THR417 |
E | MET431 |
E | TYR435 |
E | PRO447 |
E | ASN448 |
E | MET452 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue DTT E 501 |
Chain | Residue |
E | ASP377 |
E | ASN379 |
E | ASN448 |
E | LEU449 |
site_id | AD2 |
Number of Residues | 9 |
Details | binding site for residue CJA F 500 |
Chain | Residue |
C | MET452 |
F | SER413 |
F | THR417 |
F | MET431 |
F | TYR435 |
F | SER446 |
F | PRO447 |
F | ASN448 |
F | MET452 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue DTT F 501 |
Chain | Residue |
F | ASP377 |
F | ASN448 |
F | LEU449 |
Functional Information from PROSITE/UniProt
site_id | PS00383 |
Number of Residues | 11 |
Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCqaGvsRSA |
Chain | Residue | Details |
A | ILE406-ALA416 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:16806267, ECO:0000305|PubMed:17400920 |
Chain | Residue | Details |
B | CYS408 | |
C | CYS408 | |
D | CYS408 | |
E | CYS408 | |
F | CYS408 | |
A | CYS408 |