6M9T
Crystal structure of EP3 receptor bound to misoprostol-FA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0008152 | biological_process | metabolic process |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue J9P A 2101 |
| Chain | Residue |
| A | PRO55 |
| A | TRP295 |
| A | ARG333 |
| A | SER336 |
| A | GLN339 |
| A | HOH2202 |
| A | THR106 |
| A | THR107 |
| A | TYR114 |
| A | MET137 |
| A | PHE140 |
| A | GLY141 |
| A | THR206 |
| A | TRP207 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 2102 |
| Chain | Residue |
| A | ALA161 |
| A | PRO162 |
| A | HIS163 |
| A | TRP164 |
| A | ARG1008 |
| A | LEU1013 |
| A | HOH2204 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 2103 |
| Chain | Residue |
| A | THR1142 |
| A | PRO1143 |
| A | ASN1144 |
| A | ARG1145 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 2104 |
| Chain | Residue |
| A | TYR1088 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 2105 |
| Chain | Residue |
| A | MET70 |
| A | GLY93 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 2106 |
| Chain | Residue |
| A | GLN283 |
| A | ALA286 |
| A | VAL345 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 2109 |
| Chain | Residue |
| A | ALA286 |
| A | CYS289 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue OLA A 2110 |
| Chain | Residue |
| A | PHE54 |
| A | MET58 |
| A | ILE330 |
| A | ARG333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE54-ARG78 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG79-CYS91 | |
| A | GLU154-ARG175 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE92-VAL112 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 66 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL113-THR131 | |
| A | GLN198-ASN227 | |
| A | ASN308-PHE327 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE132-VAL153 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA176-GLY197 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU228-ILE253 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU284-PHE307 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE328-LEU349 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN18 | |
| A | ASN36 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | GLU1011 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | ASP1020 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | LEU1032 | |
| A | PHE1104 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
| Chain | Residue | Details |
| A | SER1117 | |
| A | ASN1132 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 921 |
| Chain | Residue | Details |
| A | GLU1011 | proton shuttle (general acid/base) |
| A | ASP1020 | covalent catalysis |
