6M84

Crystal structure of cKir2.2 force open mutant in complex with PI(4,5)P2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue K A 401

Chain	Residue
A	TYR146
A	TYR146
A	TYR146
A	TYR146
A	K402
A	K402
A	K402
A	K402

---

site_id	AC2
Number of Residues	16
Details	binding site for residue K A 402

Chain	Residue
A	GLY145
A	GLY145
A	GLY145
A	TYR146
A	TYR146
A	TYR146
A	TYR146
A	K401
A	K401
A	K401
A	K401
A	K403
A	K403
A	K403
A	K403
A	GLY145

---

site_id	AC3
Number of Residues	16
Details	binding site for residue K A 403

Chain	Residue
A	ILE144
A	ILE144
A	ILE144
A	ILE144
A	GLY145
A	GLY145
A	GLY145
A	GLY145
A	K402
A	K402
A	K402
A	K402
A	K404
A	K404
A	K404
A	K404

---

site_id	AC4
Number of Residues	12
Details	binding site for residue K A 404

Chain	Residue
A	THR143
A	THR143
A	THR143
A	THR143
A	ILE144
A	ILE144
A	ILE144
A	ILE144
A	K403
A	K403
A	K403
A	K403

---

site_id	AC5
Number of Residues	4
Details	binding site for residue K A 405

Chain	Residue
A	THR143
A	THR143
A	THR143
A	THR143

---

site_id	AC6
Number of Residues	8
Details	binding site for residue PIO A 407

Chain	Residue
A	ASP76
A	ARG78
A	TRP79
A	ARG80
A	LYS183
A	ARG186
A	LYS188
A	LYS189

---

site_id	AC7
Number of Residues	6
Details	binding site for residue LMT A 408

Chain	Residue
A	MET59
A	TRP62
A	TYR66
A	ILE77
A	HOH502
A	HOH516

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	33
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Intramembrane: {"description":"Helical; Pore-forming; Name=H5","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"20019282","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---