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6M69

Crystal structure of Mycobacterium smegmatis MutT1 in complex with GMPPCP (GDP)

Functional Information from GO Data
ChainGOidnamespacecontents
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0016787molecular_functionhydrolase activity
A0044715molecular_function8-oxo-dGDP phosphatase activity
A0044716molecular_function8-oxo-GDP phosphatase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue GDP A 401
ChainResidue
AARG55
AHOH536
AHOH560
AHOH568
AHOH599
AHOH605
AHOH644
AHOH683
AHOH739
ATYR58
ALYS65
ATYR101
ALYS108
ATYR145
AMG405
AHOH515
AHOH517

site_idAC2
Number of Residues12
Detailsbinding site for residue POP A 402
ChainResidue
AARG169
AHIS170
AARG176
AARG186
AARG218
AGLN271
AGLY272
ALYS297
AHOH513
AHOH542
AHOH640
AHOH642

site_idAC3
Number of Residues4
Detailsbinding site for residue EDO A 403
ChainResidue
AARG169
AHOH503
AHOH513
AHOH524

site_idAC4
Number of Residues8
Detailsbinding site for residue EDO A 404
ChainResidue
ATHR162
ATHR164
AASN265
AHOH516
AHOH555
AHOH562
AHOH590
AHOH746

site_idAC5
Number of Residues3
Detailsbinding site for residue MG A 405
ChainResidue
ALYS65
ATYR101
AGDP401

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkldqgEtepvAAaREIhEEtG
ChainResidueDetails
AGLY66-GLY87

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:28375146, ECO:0000269|PubMed:28705712
ChainResidueDetails
AARG55
ALYS65
AGLU81
AGLU85
ATYR101
ALYS108
AGLU127
ATYR145

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:28375146
ChainResidueDetails
AASP60

226707

PDB entries from 2024-10-30

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