6M4V

Crystal structure of MBP fused split FKBP in complex with rapamycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005515	molecular_function	protein binding
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0071702	biological_process	organic substance transport
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005515	molecular_function	protein binding
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	0071702	biological_process	organic substance transport
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue RAP B 201

Chain	Residue
A	TYR27
B	TYR83
B	ILE92
B	PHE100
B	PHE37
B	ASP38
B	PHE47
B	GLN54
B	GLU55
B	VAL56
B	ILE57
B	TRP60

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site_id	AC2
Number of Residues	14
Details	binding site for residue RAP D 201

Chain	Residue
C	TYR27
D	PHE37
D	ASP38
D	PHE47
D	GLN54
D	GLU55
D	VAL56
D	ILE57
D	TRP60
D	TYR83
D	ILE91
D	ILE92
D	PHE100
D	HOH303

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Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO-263-ASN-246

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883

Chain	Residue	Details
B	LYS53
D	LYS53

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 362

Chain	Residue	Details
B	PHE37	electrostatic destabiliser, polar/non-polar interaction, steric role
B	ASP38	electrostatic stabiliser, steric role
B	ILE57	electrostatic stabiliser, steric role
B	TYR83	electrostatic stabiliser, steric role
B	PHE100	electrostatic destabiliser, polar/non-polar interaction, steric role

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 362

Chain	Residue	Details
D	PHE37	electrostatic destabiliser, polar/non-polar interaction, steric role
D	ASP38	electrostatic stabiliser, steric role
D	ILE57	electrostatic stabiliser, steric role
D	TYR83	electrostatic stabiliser, steric role
D	PHE100	electrostatic destabiliser, polar/non-polar interaction, steric role

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