6M31
Structural and Functional Insights into an Archaeal Lipid Synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006650 | biological_process | glycerophospholipid metabolic process |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0047295 | molecular_function | geranylgeranylglycerol-phosphate geranylgeranyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006650 | biological_process | glycerophospholipid metabolic process |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0047295 | molecular_function | geranylgeranylglycerol-phosphate geranylgeranyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue LDA A 301 |
| Chain | Residue |
| A | THR22 |
| A | THR144 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue LDA A 302 |
| Chain | Residue |
| A | HOH406 |
| B | LEU42 |
| A | PRO134 |
| A | TRP173 |
| A | TYR199 |
| A | SER203 |
| A | TRP230 |
| A | LDA309 |
| A | MPG318 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue LDA A 303 |
| Chain | Residue |
| A | LEU42 |
| A | MPG317 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue LDA A 304 |
| Chain | Residue |
| A | ILE41 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue LDA A 305 |
| Chain | Residue |
| B | LDA310 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue LDA A 306 |
| Chain | Residue |
| A | TYR110 |
| A | TYR142 |
| A | LDA308 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue LDA A 307 |
| Chain | Residue |
| A | TYR57 |
| A | LEU97 |
| A | LEU120 |
| A | TYR123 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue LDA A 308 |
| Chain | Residue |
| A | TYR110 |
| A | LDA306 |
| A | LDA311 |
| A | MPG328 |
| B | PHE4 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue LDA A 309 |
| Chain | Residue |
| A | TYR132 |
| A | PRO134 |
| A | TRP230 |
| A | LDA302 |
| B | LDA306 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue LDA A 310 |
| Chain | Residue |
| A | LYS90 |
| A | ALA94 |
| A | ILE98 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue LDA A 311 |
| Chain | Residue |
| A | ASN157 |
| A | VAL158 |
| A | MET159 |
| A | LDA308 |
| A | MPG328 |
| B | PHE4 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 312 |
| Chain | Residue |
| A | ARG16 |
| A | LYS74 |
| A | ARG77 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 313 |
| Chain | Residue |
| A | ARG175 |
| A | LYS179 |
| A | LYS266 |
| A | MPG323 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 314 |
| Chain | Residue |
| A | ASN62 |
| A | ASP66 |
| A | ASP70 |
| A | LYS74 |
| A | LYS130 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 315 |
| Chain | Residue |
| A | ASP63 |
| A | ASP70 |
| A | LEU79 |
| A | PRO80 |
| A | HOH415 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MPG A 316 |
| Chain | Residue |
| A | LEU105 |
| A | PHE106 |
| A | ILE107 |
| A | MPG317 |
| A | MPG320 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MPG A 317 |
| Chain | Residue |
| A | LEU45 |
| A | PHE106 |
| A | LDA303 |
| A | MPG316 |
| A | MPG326 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue MPG A 318 |
| Chain | Residue |
| A | TYR205 |
| A | PHE206 |
| A | PHE209 |
| A | LDA302 |
| B | LYS43 |
| B | PHE106 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MPG A 319 |
| Chain | Residue |
| A | LEU12 |
| A | ARG16 |
| A | VAL17 |
| A | LYS18 |
| A | MPG325 |
| B | LDA308 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue MPG A 320 |
| Chain | Residue |
| A | LEU105 |
| A | ASN108 |
| A | ILE109 |
| A | TYR244 |
| A | MPG316 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue MPG A 321 |
| Chain | Residue |
| A | TYR205 |
| B | LEU105 |
| B | PHE106 |
| B | ILE107 |
| B | MPG316 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue MPG A 322 |
| Chain | Residue |
| A | ILE223 |
| A | LEU224 |
| B | TYR11 |
| B | PHE52 |
| B | GLU88 |
| B | ILE95 |
| site_id | AE5 |
| Number of Residues | 13 |
| Details | binding site for residue MPG A 323 |
| Chain | Residue |
| A | SER171 |
| A | ARG175 |
| A | GLU176 |
| A | LYS179 |
| A | ALA214 |
| A | SER218 |
| A | ASP239 |
| A | PHE242 |
| A | MET269 |
| A | PO4313 |
| A | ILE140 |
| A | CYS167 |
| A | SER168 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue MPG A 324 |
| Chain | Residue |
| A | ARG16 |
| A | VAL54 |
| A | ASN59 |
| A | ASN62 |
| A | ASN118 |
| A | TYR125 |
| A | THR144 |
| A | PHE150 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue MPG A 325 |
| Chain | Residue |
| A | ILE28 |
| A | ILE41 |
| A | SER44 |
| A | LEU45 |
| A | PHE48 |
| A | MPG319 |
| B | ILE267 |
| B | ASN270 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue MPG A 326 |
| Chain | Residue |
| A | TYR11 |
| A | PHE52 |
| A | GLU88 |
| A | LYS91 |
| A | PHE92 |
| A | LEU99 |
| A | MPG317 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue MPG A 327 |
| Chain | Residue |
| A | ILE28 |
| A | ASN270 |
| B | LDA310 |
| B | MPG319 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue MPG A 328 |
| Chain | Residue |
| A | TYR110 |
| A | VAL153 |
| A | GLY155 |
| A | LYS156 |
| A | VAL158 |
| A | ILE271 |
| A | LDA308 |
| A | LDA311 |
| B | MPG317 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue LDA B 301 |
| Chain | Residue |
| B | TYR110 |
| B | VAL153 |
| B | GLY155 |
| B | VAL158 |
| B | PHE165 |
| B | LDA309 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue LDA B 302 |
| Chain | Residue |
| B | THR22 |
| B | GLY26 |
| B | THR144 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue LDA B 303 |
| Chain | Residue |
| B | TYR57 |
| B | ALA119 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue LDA B 304 |
| Chain | Residue |
| B | MPG319 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue LDA B 305 |
| Chain | Residue |
| B | PHE264 |
| B | LDA308 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue LDA B 306 |
| Chain | Residue |
| A | LEU210 |
| A | LDA309 |
| B | ASP40 |
| B | ILE41 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue LDA B 307 |
| Chain | Residue |
| B | PHE48 |
| B | PHE49 |
| B | MPG319 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue LDA B 308 |
| Chain | Residue |
| A | MPG319 |
| B | ILE271 |
| B | LDA305 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue LDA B 309 |
| Chain | Residue |
| B | LYS156 |
| B | ASN157 |
| B | VAL158 |
| B | MET159 |
| B | LDA301 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue LDA B 310 |
| Chain | Residue |
| A | LDA305 |
| A | MPG327 |
| B | LYS266 |
| B | ASN270 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue LDA B 311 |
| Chain | Residue |
| B | LEU224 |
| B | LYS225 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue LDA B 312 |
| Chain | Residue |
| A | ILE223 |
| B | LYS91 |
| B | ILE98 |
| B | PO4314 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 313 |
| Chain | Residue |
| B | ARG16 |
| B | LYS74 |
| B | ARG77 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 B 314 |
| Chain | Residue |
| A | LYS127 |
| A | LYS225 |
| B | LYS91 |
| B | LDA312 |
| B | HOH408 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 315 |
| Chain | Residue |
| B | ASP63 |
| B | ASP70 |
| B | LEU79 |
| B | PRO80 |
| B | HOH407 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue MPG B 316 |
| Chain | Residue |
| A | MPG321 |
| B | LEU105 |
| B | ASN108 |
| B | ILE109 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue MPG B 317 |
| Chain | Residue |
| A | MPG328 |
| B | LEU12 |
| B | ARG16 |
| B | LYS18 |
| B | ASN19 |
| site_id | AH1 |
| Number of Residues | 7 |
| Details | binding site for residue MPG B 318 |
| Chain | Residue |
| B | SER168 |
| B | SER171 |
| B | ARG175 |
| B | LYS179 |
| B | PHE242 |
| B | LYS266 |
| B | VAL272 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue MPG B 319 |
| Chain | Residue |
| A | MPG327 |
| B | ASN270 |
| B | LDA304 |
| B | LDA307 |
| site_id | AH3 |
| Number of Residues | 8 |
| Details | binding site for residue MPG B 320 |
| Chain | Residue |
| B | ARG16 |
| B | VAL54 |
| B | ASN59 |
| B | ASN62 |
| B | ASN118 |
| B | LEU143 |
| B | THR144 |
| B | PHE150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_01286 |
| Chain | Residue | Details |
| B | ILE21-ILE41 | |
| B | LEU45-PHE65 | |
| B | LEU97-ILE117 | |
| B | ILE135-GLY155 | |
| B | VAL158-VAL178 | |
| B | LEU204-LEU224 | |
| B | ILE226-MET246 | |
| B | VAL261-ILE281 | |
| A | ILE21-ILE41 | |
| A | LEU45-PHE65 | |
| A | LEU97-ILE117 | |
| A | ILE135-GLY155 | |
| A | VAL158-VAL178 | |
| A | LEU204-LEU224 | |
| A | ILE226-MET246 | |
| A | VAL261-ILE281 |
