6M23
Overall structure of KCC2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0006971 | biological_process | hypotonic response |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007612 | biological_process | learning |
| A | 0008519 | molecular_function | ammonium channel activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0030644 | biological_process | intracellular chloride ion homeostasis |
| A | 0032502 | biological_process | developmental process |
| A | 0032590 | cellular_component | dendrite membrane |
| A | 0035264 | biological_process | multicellular organism growth |
| A | 0040040 | biological_process | thermosensory behavior |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043204 | cellular_component | perikaryon |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051452 | biological_process | intracellular pH reduction |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060996 | biological_process | dendritic spine development |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0071944 | cellular_component | cell periphery |
| A | 0072488 | biological_process | ammonium transmembrane transport |
| A | 0098970 | biological_process | postsynaptic neurotransmitter receptor diffusion trapping |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099634 | cellular_component | postsynaptic specialization membrane |
| A | 0150052 | biological_process | regulation of postsynapse assembly |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0006971 | biological_process | hypotonic response |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0007612 | biological_process | learning |
| B | 0008519 | molecular_function | ammonium channel activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0030644 | biological_process | intracellular chloride ion homeostasis |
| B | 0032502 | biological_process | developmental process |
| B | 0032590 | cellular_component | dendrite membrane |
| B | 0035264 | biological_process | multicellular organism growth |
| B | 0040040 | biological_process | thermosensory behavior |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043204 | cellular_component | perikaryon |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051452 | biological_process | intracellular pH reduction |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060996 | biological_process | dendritic spine development |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0071944 | cellular_component | cell periphery |
| B | 0072488 | biological_process | ammonium transmembrane transport |
| B | 0098970 | biological_process | postsynaptic neurotransmitter receptor diffusion trapping |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099634 | cellular_component | postsynaptic specialization membrane |
| B | 0150052 | biological_process | regulation of postsynapse assembly |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 378 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 126 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 56 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 28 |
| Details | Region: {"description":"Scissor helix","evidences":[{"source":"PubMed","id":"33199848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33310850","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D8Z","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33310850","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by OXSR1 and STK39","evidences":[{"source":"PubMed","id":"19665974","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
