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6M17

The 2019-nCoV RBD/ACE2-B0AT1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003333biological_processamino acid transmembrane transport
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006865biological_processamino acid transport
A0007584biological_processresponse to nutrient
A0015171molecular_functionamino acid transmembrane transporter activity
A0015175molecular_functionneutral L-amino acid transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015804biological_processneutral amino acid transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019058biological_processviral life cycle
A0022857molecular_functiontransmembrane transporter activity
A0031526cellular_componentbrush border membrane
A0035725biological_processsodium ion transmembrane transport
A0070062cellular_componentextracellular exosome
B0001618molecular_functionvirus receptor activity
B0001817biological_processregulation of cytokine production
B0002003biological_processangiotensin maturation
B0003051biological_processangiotensin-mediated drinking behavior
B0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
B0004175molecular_functionendopeptidase activity
B0004180molecular_functioncarboxypeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008241molecular_functionpeptidyl-dipeptidase activity
B0008270molecular_functionzinc ion binding
B0009986cellular_componentcell surface
B0015827biological_processtryptophan transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0019058biological_processviral life cycle
B0019065biological_processreceptor-mediated endocytosis of virus by host cell
B0019229biological_processregulation of vasoconstriction
B0022898biological_processregulation of transmembrane transporter activity
B0030666cellular_componentendocytic vesicle membrane
B0031526cellular_componentbrush border membrane
B0042127biological_processregulation of cell population proliferation
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0045121cellular_componentmembrane raft
B0046718biological_processsymbiont entry into host cell
B0046813biological_processreceptor-mediated virion attachment to host cell
B0046872molecular_functionmetal ion binding
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050727biological_processregulation of inflammatory response
B0051957biological_processpositive regulation of amino acid transport
B0060135biological_processmaternal process involved in female pregnancy
B0060452biological_processpositive regulation of cardiac muscle contraction
B0061025biological_processmembrane fusion
B0070062cellular_componentextracellular exosome
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0097746biological_processblood vessel diameter maintenance
B0098670biological_processentry receptor-mediated virion attachment to host cell
B1903598biological_processpositive regulation of gap junction assembly
B1903779biological_processregulation of cardiac conduction
B1905737biological_processpositive regulation of L-proline import across plasma membrane
B2000272biological_processnegative regulation of signaling receptor activity
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0003333biological_processamino acid transmembrane transport
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006865biological_processamino acid transport
C0007584biological_processresponse to nutrient
C0015171molecular_functionamino acid transmembrane transporter activity
C0015175molecular_functionneutral L-amino acid transmembrane transporter activity
C0015293molecular_functionsymporter activity
C0015804biological_processneutral amino acid transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019058biological_processviral life cycle
C0022857molecular_functiontransmembrane transporter activity
C0031526cellular_componentbrush border membrane
C0035725biological_processsodium ion transmembrane transport
C0070062cellular_componentextracellular exosome
D0001618molecular_functionvirus receptor activity
D0001817biological_processregulation of cytokine production
D0002003biological_processangiotensin maturation
D0003051biological_processangiotensin-mediated drinking behavior
D0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
D0004175molecular_functionendopeptidase activity
D0004180molecular_functioncarboxypeptidase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005788cellular_componentendoplasmic reticulum lumen
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0006508biological_processproteolysis
D0008237molecular_functionmetallopeptidase activity
D0008241molecular_functionpeptidyl-dipeptidase activity
D0008270molecular_functionzinc ion binding
D0009986cellular_componentcell surface
D0015827biological_processtryptophan transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0019058biological_processviral life cycle
D0019065biological_processreceptor-mediated endocytosis of virus by host cell
D0019229biological_processregulation of vasoconstriction
D0022898biological_processregulation of transmembrane transporter activity
D0030666cellular_componentendocytic vesicle membrane
D0031526cellular_componentbrush border membrane
D0042127biological_processregulation of cell population proliferation
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0045121cellular_componentmembrane raft
D0046718biological_processsymbiont entry into host cell
D0046813biological_processreceptor-mediated virion attachment to host cell
D0046872molecular_functionmetal ion binding
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0050727biological_processregulation of inflammatory response
D0051957biological_processpositive regulation of amino acid transport
D0060135biological_processmaternal process involved in female pregnancy
D0060452biological_processpositive regulation of cardiac muscle contraction
D0061025biological_processmembrane fusion
D0070062cellular_componentextracellular exosome
D0070373biological_processnegative regulation of ERK1 and ERK2 cascade
D0097746biological_processblood vessel diameter maintenance
D0098670biological_processentry receptor-mediated virion attachment to host cell
D1903598biological_processpositive regulation of gap junction assembly
D1903779biological_processregulation of cardiac conduction
D1905737biological_processpositive regulation of L-proline import across plasma membrane
D2000272biological_processnegative regulation of signaling receptor activity
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
BTHR371-GLN380

site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqsHGGGaF
ChainResidueDetails
ATRP56-PHE70

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391
ChainResidueDetails
ETHR323
FTHR323

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391
ChainResidueDetails
ESER325
CGLY326-SER413
CGLY478-GLY490
CGLU553-TRP581
FSER325
ATHR243-TRP268
AGLY326-SER413
AGLY478-GLY490
AGLU553-TRP581
CGLN63-GLY67
CASN142-SER192
CTHR243-TRP268

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
EASN331
EASN343
FASN331
FASN343

site_idSWS_FT_FI4
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402
ChainResidueDetails
BGLU375
CASN435-GLU456
CASP512-GLN531
CTYR603-TYR634
DGLU375
ASER290-VAL304
AASN435-GLU456
AASP512-GLN531
ATYR603-TYR634
CGLU89-LEU120
CARG214-LYS221
CSER290-VAL304

site_idSWS_FT_FI5
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895
ChainResidueDetails
BHIS505
DHIS505

site_idSWS_FT_FI6
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774
ChainResidueDetails
BARG169
BTRP477
BLYS481
DARG169
DTRP477
DLYS481

site_idSWS_FT_FI7
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:14754895
ChainResidueDetails
BARG273
BHIS345
BTYR515
DARG273
DHIS345
DTYR515

site_idSWS_FT_FI8
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895
ChainResidueDetails
BHIS374
BHIS378
BGLU402
DHIS374
DHIS378
DGLU402

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498
ChainResidueDetails
BTYR781
DTYR781

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498
ChainResidueDetails
BSER783
DSER783

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895
ChainResidueDetails
BASN53
BASN322
DASN53
DASN322

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337
ChainResidueDetails
BASN90
DASN90

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895
ChainResidueDetails
BASN103
BASN432
DASN103
DASN432

site_idSWS_FT_FI14
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337
ChainResidueDetails
BASN546
DASN546

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN690
DASN690
CSER17
CSER627

site_idSWS_FT_FI16
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523
ChainResidueDetails
BLYS788
CASN368
AASN182
DLYS788
AASN354
AASN368
CASN158
CASN182
CASN258
CASN354

226707

PDB entries from 2024-10-30

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