6M08

Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
B	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue BWL B 501

Chain	Residue
B	PHE110
B	PHE357
B	LEU371
B	LEU121
B	LEU153
B	SER273
B	PHE274
B	TRP298
B	PHE322
B	HIS351
B	GLN352

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Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. IAVIGHSFGG

Chain	Residue	Details
A	ILE267-GLY276

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:18784071

Chain	Residue	Details
A	SER273
B	SER273

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10037, ECO:0000269|PubMed:18784071

Chain	Residue	Details
A	ASP296
A	HIS351
B	ASP296
B	HIS351

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN423
B	ASN423

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