Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| A | ASP200 |
| A | HOH511 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 402 |
| Chain | Residue |
| A | GLU190 |
| A | HOH554 |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue PHN A 403 |
| Chain | Residue |
| A | TYR106 |
| A | SER107 |
| A | GLN108 |
| A | TYR110 |
| A | ILE156 |
| A | TYR157 |
| A | GLN158 |
| A | ASN227 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PHN A 404 |
| Chain | Residue |
| A | ALA64 |
| A | TYR66 |
| A | SER218 |
| A | TYR251 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PHN A 405 |
| Chain | Residue |
| A | ILE131 |
| A | PRO195 |
| A | PHN406 |
| A | HOH768 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PHN A 406 |
| Chain | Residue |
| A | LEU14 |
| A | PHN405 |
| A | PHN407 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue PHN A 407 |
| Chain | Residue |
| A | ARG11 |
| A | LEU14 |
| A | GLN17 |
| A | GLN61 |
| A | PHE63 |
| A | PHN406 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PHN A 408 |
| Chain | Residue |
| A | ARG101 |
| A | GLN119 |
| A | HOH617 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PHN A 409 |
| Chain | Residue |
| A | SER5 |
| A | ASN33 |
| A | HOH640 |
| A | HOH702 |
| A | HOH710 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
