Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue CA A 401 |
Chain | Residue |
A | TYR193 |
A | THR194 |
A | ILE197 |
A | ASP200 |
A | HOH511 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CA A 402 |
Chain | Residue |
A | GLU190 |
A | HOH554 |
A | ASP138 |
A | GLU177 |
A | ASP185 |
A | GLU187 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue PHN A 403 |
Chain | Residue |
A | TYR106 |
A | SER107 |
A | GLN108 |
A | TYR110 |
A | ILE156 |
A | TYR157 |
A | GLN158 |
A | ASN227 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue PHN A 404 |
Chain | Residue |
A | ALA64 |
A | TYR66 |
A | SER218 |
A | TYR251 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue PHN A 405 |
Chain | Residue |
A | ILE131 |
A | PRO195 |
A | PHN406 |
A | HOH768 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue PHN A 406 |
Chain | Residue |
A | LEU14 |
A | PHN405 |
A | PHN407 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue PHN A 407 |
Chain | Residue |
A | ARG11 |
A | LEU14 |
A | GLN17 |
A | GLN61 |
A | PHE63 |
A | PHN406 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue PHN A 408 |
Chain | Residue |
A | ARG101 |
A | GLN119 |
A | HOH617 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue PHN A 409 |
Chain | Residue |
A | SER5 |
A | ASN33 |
A | HOH640 |
A | HOH702 |
A | HOH710 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
Chain | Residue | Details |
A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU143 | |
Chain | Residue | Details |
A | HIS231 | |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP57 | |
A | ASP185 | |
A | GLU187 | |
A | GLU190 | |
A | TYR193 | |
A | THR194 | |
A | ILE197 | |
A | ASP200 | |
A | ASP59 | |
A | GLN61 | |
A | ASP138 | |
A | HIS142 | |
A | HIS146 | |
A | GLU166 | |
A | GLU177 | |
A | ASN183 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 176 |
Chain | Residue | Details |
A | HIS142 | metal ligand |
A | GLU143 | electrostatic stabiliser, metal ligand |
A | HIS146 | metal ligand |
A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
A | GLU166 | metal ligand |
A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |