Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LYL

Crystal structure of S1052D mutant of Formylglycinamidine synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 2001

Chain	Residue
A	HIS219
A	ASN259
A	LYS292
A	GLU294
A	LYS776

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 A 2002

Chain	Residue
A	HIS298
A	SER778
A	HOH2103
A	HOH2144
A	HOH2714
A	HIS216
A	THR295
A	HIS296
A	ASN297

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 2003

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH2125
A	HOH2351
A	HOH2488
A	HOH2504

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 2004

Chain	Residue
A	HIS216
A	GLU294
A	GLY504
A	ALA505
A	LYS776

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 2005

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP2008
A	HOH2203
A	HOH2547

site_id	AC6
Number of Residues	6
Details	binding site for residue MG A 2006

Chain	Residue
A	GLU718
A	ADP2008
A	HOH2145
A	HOH2235
A	HOH2319
A	HOH2365

site_id	AC7
Number of Residues	5
Details	binding site for residue MG A 2007

Chain	Residue
A	ADP2008
A	HOH2140
A	HOH2147
A	HOH2490
A	HOH2495

site_id	AC8
Number of Residues	33
Details	binding site for residue ADP A 2008

Chain	Residue
A	VAL333
A	THR386
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	VAL653
A	GLN668
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG2005
A	MG2006
A	MG2007
A	HOH2140
A	HOH2147
A	HOH2203
A	HOH2235
A	HOH2294
A	HOH2303
A	HOH2319
A	HOH2365
A	HOH2389
A	HOH2475
A	HOH2490
A	HOH2495
A	HOH2508
A	HOH2547
A	HOH2665

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 A 2009

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH2253
A	HOH2590

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 A 2010

Chain	Residue
A	ARG812
A	LYS1228
A	VAL1229
A	HOH2158
A	HOH2227
A	HOH2254

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 A 2011

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH2131
A	HOH2285
A	HOH2443

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 A 2012

Chain	Residue
A	HIS1086
A	HOH2237
A	HOH2352
A	HOH2491
A	PRO1040
A	LYS1041

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 A 2013

Chain	Residue
A	THR632
A	ILE633
A	HOH2110
A	HOH2466

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 A 2014

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH2394

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 A 2015

Chain	Residue
A	LYS833
A	HIS835
A	ARG858
A	HOH2156
A	HOH2579

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 A 2016

Chain	Residue
A	ALA13
A	PHE14
A	ASN998
A	HIS1161

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 A 2017

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH2640

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 A 2018

Chain	Residue
A	HIS68
A	THR69

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 A 2019

Chain	Residue
A	ALA911
A	HIS953
A	HOH2128
A	HOH2407

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 A 2020

Chain	Residue
A	VAL432
A	THR581
A	GLU582
A	GLU583

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 A 2021

Chain	Residue
A	THR247
A	LYS638
A	TRP984
A	HOH2239
A	HOH2358

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 A 2022

Chain	Residue
A	HIS153
A	GLN154

site_id	AE5
Number of Residues	3
Details	binding site for residue SO4 A 2023

Chain	Residue
A	GLN54
A	HIS1114
A	HOH2163

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 A 2024

Chain	Residue
A	ARG218
A	ASN223
A	LYS611
A	HOH2328

site_id	AE7
Number of Residues	2
Details	binding site for residue SO4 A 2025

Chain	Residue
A	ASN1251
A	ARG1253

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL A 2026

Chain	Residue
A	HIS902
A	GLY961
A	ARG978
A	ASP1012
A	HOH2146
A	HOH2484

site_id	AE9
Number of Residues	9
Details	binding site for residue GOL A 2027

Chain	Residue
A	GLU648
A	THR650
A	TRP673
A	GLN674
A	GLU1005
A	LYS1009
A	HOH2123
A	HOH2355
A	HOH2422

site_id	AF1
Number of Residues	7
Details	binding site for residue GOL A 2028

Chain	Residue
A	SER689
A	TYR690
A	TYR691
A	VAL1229
A	THR1230
A	GLU1231
A	HOH2403

site_id	AF2
Number of Residues	5
Details	binding site for residue GOL A 2029

Chain	Residue
A	TYR251
A	GLU264
A	GLU1007
A	HOH2164
A	HOH2581

site_id	AF3
Number of Residues	6
Details	binding site for residue GOL A 2030

Chain	Residue
A	ALA709
A	ARG713
A	ASP755
A	LYS758
A	GLU763
A	HOH2470

site_id	AF4
Number of Residues	5
Details	binding site for residue GOL A 2031

Chain	Residue
A	LEU626
A	ARG628
A	ASP852
A	HOH2102
A	HOH2712

site_id	AF5
Number of Residues	4
Details	binding site for residue GOL A 2032

Chain	Residue
A	GLY913
A	ASP914
A	ASP915
A	HOH2149

site_id	AF6
Number of Residues	4
Details	binding site for residue GOL A 2033

Chain	Residue
A	GLU264
A	ALA267
A	ASP1003
A	GLN1004

site_id	AF7
Number of Residues	5
Details	binding site for residue GOL A 2034

Chain	Residue
A	HIS746
A	LYS782
A	ARG784
A	GLU793
A	HOH2793

site_id	AF8
Number of Residues	4
Details	binding site for residue SO4 A 2035

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH2107

site_id	AF9
Number of Residues	5
Details	binding site for residue SO4 A 2036

Chain	Residue
A	PRO1274
A	GLU1275
A	HOH2133
A	HOH2588
A	HOH2600

site_id	AG1
Number of Residues	2
Details	binding site for residue EDO A 2037

Chain	Residue
A	THR632
A	HOH2110

site_id	AG2
Number of Residues	2
Details	binding site for residue EDO A 2038

Chain	Residue
A	LYS853
A	HOH2185

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	CYG1135

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	HIS1260
A	GLU1262

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY307

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	THR386
A	ALA678
A	SER886

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419, ECO:0000269\|PubMed:15301531, ECO:0000269\|PubMed:22683785, ECO:0000269\|PubMed:24223728

Chain	Residue	Details
A	ASP679
A	GLU718
A	ASN722
A	ASP884

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)