6LYK
Crystal Structure of R1263A mutant of Formylglycinamidine Synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004642 | molecular_function | phosphoribosylformylglycinamidine synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1601 |
| Chain | Residue |
| A | ARG1145 |
| A | TRP1154 |
| A | ARG1204 |
| A | HOH2242 |
| A | HOH2685 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1602 |
| Chain | Residue |
| A | HOH2879 |
| A | ARG936 |
| A | HOH1751 |
| A | HOH1989 |
| A | HOH2818 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1603 |
| Chain | Residue |
| A | ARG666 |
| A | TRP1272 |
| A | HIS1273 |
| A | HOH1796 |
| A | HOH2127 |
| A | HOH2216 |
| A | HOH2837 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1604 |
| Chain | Residue |
| A | ARG480 |
| A | ARG571 |
| A | HOH1808 |
| A | HOH1876 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1605 |
| Chain | Residue |
| A | PHE238 |
| A | TYR256 |
| A | VAL774 |
| A | GLY775 |
| A | HOH1733 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1606 |
| Chain | Residue |
| A | ARG812 |
| A | HIS813 |
| A | ARG877 |
| A | HOH1859 |
| A | HOH2203 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1607 |
| Chain | Residue |
| A | THR247 |
| A | HOH2210 |
| A | HOH2612 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1608 |
| Chain | Residue |
| A | PRO1274 |
| A | GLU1275 |
| A | HOH1838 |
| A | HOH2845 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1609 |
| Chain | Residue |
| A | ASN48 |
| A | ASP49 |
| A | HOH2610 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1610 |
| Chain | Residue |
| A | PRO304 |
| A | ASP364 |
| A | GLU368 |
| A | HOH2437 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue IMD A 1611 |
| Chain | Residue |
| A | ARG218 |
| A | HOH2250 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1612 |
| Chain | Residue |
| A | PRO63 |
| A | ALA64 |
| A | ARG1200 |
| A | GLU1202 |
| A | HOH1727 |
| A | HOH2896 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1613 |
| Chain | Residue |
| A | PRO9 |
| A | LEU11 |
| A | TYR34 |
| A | SER66 |
| A | HOH1861 |
| A | HOH2121 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1614 |
| Chain | Residue |
| A | GLU1250 |
| A | ASN1251 |
| A | SO41637 |
| A | HOH2458 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1615 |
| Chain | Residue |
| A | HOH1744 |
| A | HOH1850 |
| A | HOH2295 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1616 |
| Chain | Residue |
| A | GLU350 |
| A | GLU351 |
| A | ARG848 |
| site_id | AD8 |
| Number of Residues | 33 |
| Details | binding site for residue ADP A 1617 |
| Chain | Residue |
| A | HOH2446 |
| A | HOH2447 |
| A | HOH2749 |
| A | VAL333 |
| A | PHE335 |
| A | THR386 |
| A | GLY387 |
| A | TYR388 |
| A | PHE389 |
| A | LYS649 |
| A | LEU652 |
| A | GLN668 |
| A | PRO676 |
| A | ALA678 |
| A | ASP679 |
| A | GLU718 |
| A | ASN722 |
| A | SER886 |
| A | MG1619 |
| A | MG1620 |
| A | MG1621 |
| A | HOH1772 |
| A | HOH1816 |
| A | HOH1817 |
| A | HOH1862 |
| A | HOH2067 |
| A | HOH2079 |
| A | HOH2102 |
| A | HOH2163 |
| A | HOH2173 |
| A | HOH2313 |
| A | HOH2366 |
| A | HOH2372 |
| site_id | AD9 |
| Number of Residues | 17 |
| Details | binding site for residue GLN A 1618 |
| Chain | Residue |
| A | GLY1092 |
| A | GLY1093 |
| A | PHE1094 |
| A | ASP1098 |
| A | CYS1135 |
| A | ASN1136 |
| A | GLN1139 |
| A | PHE1165 |
| A | SER1195 |
| A | HIS1196 |
| A | GLY1197 |
| A | GLU1198 |
| A | HIS1260 |
| A | HOH1717 |
| A | HOH1831 |
| A | HOH2091 |
| A | HOH2393 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1619 |
| Chain | Residue |
| A | GLU718 |
| A | ADP1617 |
| A | HOH1862 |
| A | HOH1982 |
| A | HOH2173 |
| A | HOH2313 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1620 |
| Chain | Residue |
| A | ADP1617 |
| A | HOH1772 |
| A | HOH1816 |
| A | HOH2079 |
| A | HOH2366 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1621 |
| Chain | Residue |
| A | ASP679 |
| A | ASN722 |
| A | ASP884 |
| A | ADP1617 |
| A | HOH2067 |
| A | HOH2446 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1622 |
| Chain | Residue |
| A | THR1013 |
| A | HOH2110 |
| A | HOH2944 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 1623 |
| Chain | Residue |
| A | HIS216 |
| A | THR295 |
| A | HIS296 |
| A | ASN297 |
| A | HIS298 |
| A | SER778 |
| A | HOH1835 |
| A | HOH1908 |
| A | HOH2112 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 1624 |
| Chain | Residue |
| A | HIS1086 |
| A | ARG1126 |
| A | PRO1127 |
| A | GLN1128 |
| A | THR1129 |
| A | HOH1766 |
| A | HOH1790 |
| A | HOH1962 |
| A | HOH2739 |
| site_id | AE7 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 1625 |
| Chain | Residue |
| A | TRP305 |
| A | ARG1159 |
| A | ARG1164 |
| A | HOH1718 |
| A | HOH1826 |
| A | HOH2201 |
| A | HOH2406 |
| A | HOH2587 |
| A | HOH2593 |
| A | HOH2790 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1626 |
| Chain | Residue |
| A | TYR690 |
| A | ARG812 |
| A | LYS1228 |
| A | VAL1229 |
| A | HOH1761 |
| A | HOH2055 |
| A | HOH2148 |
| A | HOH2349 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1627 |
| Chain | Residue |
| A | PRO356 |
| A | GLU357 |
| A | ARG358 |
| A | HOH1783 |
| A | HOH1847 |
| A | HOH1914 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1628 |
| Chain | Residue |
| A | PRO1040 |
| A | LYS1041 |
| A | HIS1086 |
| A | HOH1973 |
| A | HOH2009 |
| A | HOH2441 |
| site_id | AF2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 1629 |
| Chain | Residue |
| A | SER12 |
| A | ALA13 |
| A | PHE14 |
| A | ASN998 |
| A | HIS1161 |
| A | HOH1898 |
| A | HOH2183 |
| A | HOH2225 |
| A | HOH2453 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1630 |
| Chain | Residue |
| A | ASN1113 |
| A | ARG1115 |
| A | HOH2507 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1631 |
| Chain | Residue |
| A | THR632 |
| A | ILE633 |
| A | HOH1740 |
| A | HOH2044 |
| A | HOH2520 |
| A | HOH2528 |
| site_id | AF5 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 1632 |
| Chain | Residue |
| A | GLN1176 |
| A | GLN1183 |
| A | GLY1184 |
| A | MET1185 |
| A | VAL1186 |
| A | HOH1775 |
| A | HOH1936 |
| A | HOH2300 |
| A | HOH2511 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1633 |
| Chain | Residue |
| A | HIS216 |
| A | GLY504 |
| A | ALA505 |
| A | LYS776 |
| A | HOH1719 |
| A | HOH1731 |
| A | HOH2581 |
| A | HOH2784 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1634 |
| Chain | Residue |
| A | LYS833 |
| A | HIS835 |
| A | HOH1897 |
| A | HOH2261 |
| A | HOH2551 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1635 |
| Chain | Residue |
| A | GLN54 |
| A | PHE1112 |
| A | HIS1114 |
| A | HOH1910 |
| A | HOH1960 |
| A | HOH2227 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1636 |
| Chain | Residue |
| A | HIS68 |
| A | THR69 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1637 |
| Chain | Residue |
| A | ASN1251 |
| A | ARG1253 |
| A | EDO1614 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1638 |
| Chain | Residue |
| A | HIS152 |
| A | HIS153 |
| A | GLN154 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1639 |
| Chain | Residue |
| A | ARG-3 |
| A | GLY-2 |
| A | ILE151 |
| A | HIS152 |
| site_id | AG4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1640 |
| Chain | Residue |
| A | HIS902 |
| A | CYS903 |
| A | GLY961 |
| A | ARG978 |
| A | ASP1012 |
| A | HOH1952 |
| A | HOH2213 |
| site_id | AG5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 1641 |
| Chain | Residue |
| A | ALA911 |
| A | VAL952 |
| A | HIS953 |
| A | TYR954 |
| A | HOH1729 |
| A | HOH1734 |
| A | HOH1751 |
| A | HOH1923 |
| A | HOH2081 |
| A | HOH2354 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1642 |
| Chain | Residue |
| A | GLN767 |
| A | ASP859 |
| A | VAL860 |
| A | ALA861 |
| A | HOH2075 |
| A | HOH2285 |
| site_id | AG7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1643 |
| Chain | Residue |
| A | SER689 |
| A | TYR690 |
| A | TYR691 |
| A | THR1230 |
| A | GLU1231 |
| A | HOH1761 |
| A | HOH1802 |
| A | HOH1927 |
| site_id | AG8 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 1644 |
| Chain | Residue |
| A | ALA-9 |
| A | VAL616 |
| A | GLN617 |
| A | LEU619 |
| A | PRO747 |
| A | GLY748 |
| A | ASP750 |
| A | HOH1737 |
| A | HOH2076 |
| A | HOH2980 |
| site_id | AG9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1645 |
| Chain | Residue |
| A | ALA709 |
| A | ARG713 |
| A | ASP755 |
| A | LYS758 |
| A | GLU763 |
| A | HOH1884 |
| A | HOH1934 |
| A | HOH2484 |
| site_id | AH1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1646 |
| Chain | Residue |
| A | GLU264 |
| A | ALA267 |
| A | HIS288 |
| A | GLN1004 |
| A | HOH1912 |
| A | HOH2068 |
| A | HOH2161 |
| A | HOH2588 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1647 |
| Chain | Residue |
| A | PRO79 |
| A | SER85 |
| A | GLU107 |
| A | ARG108 |
| A | HOH1745 |
| A | HOH2306 |
| site_id | AH3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 1648 |
| Chain | Residue |
| A | GLU648 |
| A | THR650 |
| A | TRP673 |
| A | GLN674 |
| A | GLU1005 |
| A | LYS1009 |
| A | ARG1168 |
| A | HOH1739 |
| A | HOH2004 |
| A | HOH2485 |
| A | HOH2804 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1649 |
| Chain | Residue |
| A | GLY913 |
| A | ASP914 |
| A | ASP915 |
| A | HOH1891 |
| A | HOH1917 |
| A | HOH2095 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1650 |
| Chain | Residue |
| A | ARG15 |
| A | GLU368 |
| A | ARG996 |
| A | ARG1164 |
| A | HOH1774 |
| A | HOH1871 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1651 |
| Chain | Residue |
| A | THR1175 |
| A | GLN1176 |
| A | ARG1221 |
| A | HOH1722 |
| A | HOH1925 |
| site_id | AH7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1652 |
| Chain | Residue |
| A | GLY278 |
| A | ARG569 |
| A | ILE1068 |
| A | ASP1069 |
| A | ASP1074 |
| A | ARG1079 |
| A | HOH1839 |
| A | HOH2069 |
| A | HOH2660 |
| site_id | AH8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1653 |
| Chain | Residue |
| A | ASP250 |
| A | TYR251 |
| A | GLU264 |
| A | GLU1007 |
| A | HOH1978 |
| A | HOH2028 |
| A | HOH2456 |
| A | HOH2602 |
| A | HOH2927 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1654 |
| Chain | Residue |
| A | GLN29 |
| A | HIS31 |
| A | SER117 |
| A | HOH1741 |
| site_id | AI1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1655 |
| Chain | Residue |
| A | PRO1015 |
| A | ASN1018 |
| A | HOH1810 |
| A | HOH2105 |
| A | HOH2477 |
| site_id | AI2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1656 |
| Chain | Residue |
| A | SER214 |
| A | GLU215 |
| A | LYS220 |
| A | HOH1963 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 253 |
| Details | Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
