Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LYK

Crystal Structure of R1263A mutant of Formylglycinamidine Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 1601

Chain	Residue
A	ARG1145
A	TRP1154
A	ARG1204
A	HOH2242
A	HOH2685

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 1602

Chain	Residue
A	HOH2879
A	ARG936
A	HOH1751
A	HOH1989
A	HOH2818

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 1603

Chain	Residue
A	ARG666
A	TRP1272
A	HIS1273
A	HOH1796
A	HOH2127
A	HOH2216
A	HOH2837

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 1604

Chain	Residue
A	ARG480
A	ARG571
A	HOH1808
A	HOH1876

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 1605

Chain	Residue
A	PHE238
A	TYR256
A	VAL774
A	GLY775
A	HOH1733

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 1606

Chain	Residue
A	ARG812
A	HIS813
A	ARG877
A	HOH1859
A	HOH2203

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 1607

Chain	Residue
A	THR247
A	HOH2210
A	HOH2612

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 1608

Chain	Residue
A	PRO1274
A	GLU1275
A	HOH1838
A	HOH2845

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 1609

Chain	Residue
A	ASN48
A	ASP49
A	HOH2610

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 1610

Chain	Residue
A	PRO304
A	ASP364
A	GLU368
A	HOH2437

site_id	AD2
Number of Residues	2
Details	binding site for residue IMD A 1611

Chain	Residue
A	ARG218
A	HOH2250

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 1612

Chain	Residue
A	PRO63
A	ALA64
A	ARG1200
A	GLU1202
A	HOH1727
A	HOH2896

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 1613

Chain	Residue
A	PRO9
A	LEU11
A	TYR34
A	SER66
A	HOH1861
A	HOH2121

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 1614

Chain	Residue
A	GLU1250
A	ASN1251
A	SO41637
A	HOH2458

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 1615

Chain	Residue
A	HOH1744
A	HOH1850
A	HOH2295

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 1616

Chain	Residue
A	GLU350
A	GLU351
A	ARG848

site_id	AD8
Number of Residues	33
Details	binding site for residue ADP A 1617

Chain	Residue
A	HOH2446
A	HOH2447
A	HOH2749
A	VAL333
A	PHE335
A	THR386
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	GLN668
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1619
A	MG1620
A	MG1621
A	HOH1772
A	HOH1816
A	HOH1817
A	HOH1862
A	HOH2067
A	HOH2079
A	HOH2102
A	HOH2163
A	HOH2173
A	HOH2313
A	HOH2366
A	HOH2372

site_id	AD9
Number of Residues	17
Details	binding site for residue GLN A 1618

Chain	Residue
A	GLY1092
A	GLY1093
A	PHE1094
A	ASP1098
A	CYS1135
A	ASN1136
A	GLN1139
A	PHE1165
A	SER1195
A	HIS1196
A	GLY1197
A	GLU1198
A	HIS1260
A	HOH1717
A	HOH1831
A	HOH2091
A	HOH2393

site_id	AE1
Number of Residues	6
Details	binding site for residue MG A 1619

Chain	Residue
A	GLU718
A	ADP1617
A	HOH1862
A	HOH1982
A	HOH2173
A	HOH2313

site_id	AE2
Number of Residues	5
Details	binding site for residue MG A 1620

Chain	Residue
A	ADP1617
A	HOH1772
A	HOH1816
A	HOH2079
A	HOH2366

site_id	AE3
Number of Residues	6
Details	binding site for residue MG A 1621

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1617
A	HOH2067
A	HOH2446

site_id	AE4
Number of Residues	3
Details	binding site for residue MG A 1622

Chain	Residue
A	THR1013
A	HOH2110
A	HOH2944

site_id	AE5
Number of Residues	9
Details	binding site for residue SO4 A 1623

Chain	Residue
A	HIS216
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER778
A	HOH1835
A	HOH1908
A	HOH2112

site_id	AE6
Number of Residues	9
Details	binding site for residue SO4 A 1624

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1766
A	HOH1790
A	HOH1962
A	HOH2739

site_id	AE7
Number of Residues	10
Details	binding site for residue SO4 A 1625

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1718
A	HOH1826
A	HOH2201
A	HOH2406
A	HOH2587
A	HOH2593
A	HOH2790

site_id	AE8
Number of Residues	8
Details	binding site for residue SO4 A 1626

Chain	Residue
A	TYR690
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1761
A	HOH2055
A	HOH2148
A	HOH2349

site_id	AE9
Number of Residues	6
Details	binding site for residue SO4 A 1627

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH1783
A	HOH1847
A	HOH1914

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 A 1628

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH1973
A	HOH2009
A	HOH2441

site_id	AF2
Number of Residues	9
Details	binding site for residue SO4 A 1629

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161
A	HOH1898
A	HOH2183
A	HOH2225
A	HOH2453

site_id	AF3
Number of Residues	3
Details	binding site for residue SO4 A 1630

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH2507

site_id	AF4
Number of Residues	6
Details	binding site for residue SO4 A 1631

Chain	Residue
A	THR632
A	ILE633
A	HOH1740
A	HOH2044
A	HOH2520
A	HOH2528

site_id	AF5
Number of Residues	9
Details	binding site for residue SO4 A 1632

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1775
A	HOH1936
A	HOH2300
A	HOH2511

site_id	AF6
Number of Residues	8
Details	binding site for residue SO4 A 1633

Chain	Residue
A	HIS216
A	GLY504
A	ALA505
A	LYS776
A	HOH1719
A	HOH1731
A	HOH2581
A	HOH2784

site_id	AF7
Number of Residues	5
Details	binding site for residue SO4 A 1634

Chain	Residue
A	LYS833
A	HIS835
A	HOH1897
A	HOH2261
A	HOH2551

site_id	AF8
Number of Residues	6
Details	binding site for residue SO4 A 1635

Chain	Residue
A	GLN54
A	PHE1112
A	HIS1114
A	HOH1910
A	HOH1960
A	HOH2227

site_id	AF9
Number of Residues	2
Details	binding site for residue SO4 A 1636

Chain	Residue
A	HIS68
A	THR69

site_id	AG1
Number of Residues	3
Details	binding site for residue SO4 A 1637

Chain	Residue
A	ASN1251
A	ARG1253
A	EDO1614

site_id	AG2
Number of Residues	3
Details	binding site for residue SO4 A 1638

Chain	Residue
A	HIS152
A	HIS153
A	GLN154

site_id	AG3
Number of Residues	4
Details	binding site for residue SO4 A 1639

Chain	Residue
A	ARG-3
A	GLY-2
A	ILE151
A	HIS152

site_id	AG4
Number of Residues	7
Details	binding site for residue GOL A 1640

Chain	Residue
A	HIS902
A	CYS903
A	GLY961
A	ARG978
A	ASP1012
A	HOH1952
A	HOH2213

site_id	AG5
Number of Residues	10
Details	binding site for residue GOL A 1641

Chain	Residue
A	ALA911
A	VAL952
A	HIS953
A	TYR954
A	HOH1729
A	HOH1734
A	HOH1751
A	HOH1923
A	HOH2081
A	HOH2354

site_id	AG6
Number of Residues	6
Details	binding site for residue GOL A 1642

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH2075
A	HOH2285

site_id	AG7
Number of Residues	8
Details	binding site for residue GOL A 1643

Chain	Residue
A	SER689
A	TYR690
A	TYR691
A	THR1230
A	GLU1231
A	HOH1761
A	HOH1802
A	HOH1927

site_id	AG8
Number of Residues	10
Details	binding site for residue GOL A 1644

Chain	Residue
A	ALA-9
A	VAL616
A	GLN617
A	LEU619
A	PRO747
A	GLY748
A	ASP750
A	HOH1737
A	HOH2076
A	HOH2980

site_id	AG9
Number of Residues	8
Details	binding site for residue GOL A 1645

Chain	Residue
A	ALA709
A	ARG713
A	ASP755
A	LYS758
A	GLU763
A	HOH1884
A	HOH1934
A	HOH2484

site_id	AH1
Number of Residues	8
Details	binding site for residue GOL A 1646

Chain	Residue
A	GLU264
A	ALA267
A	HIS288
A	GLN1004
A	HOH1912
A	HOH2068
A	HOH2161
A	HOH2588

site_id	AH2
Number of Residues	6
Details	binding site for residue GOL A 1647

Chain	Residue
A	PRO79
A	SER85
A	GLU107
A	ARG108
A	HOH1745
A	HOH2306

site_id	AH3
Number of Residues	11
Details	binding site for residue GOL A 1648

Chain	Residue
A	GLU648
A	THR650
A	TRP673
A	GLN674
A	GLU1005
A	LYS1009
A	ARG1168
A	HOH1739
A	HOH2004
A	HOH2485
A	HOH2804

site_id	AH4
Number of Residues	6
Details	binding site for residue GOL A 1649

Chain	Residue
A	GLY913
A	ASP914
A	ASP915
A	HOH1891
A	HOH1917
A	HOH2095

site_id	AH5
Number of Residues	6
Details	binding site for residue GOL A 1650

Chain	Residue
A	ARG15
A	GLU368
A	ARG996
A	ARG1164
A	HOH1774
A	HOH1871

site_id	AH6
Number of Residues	5
Details	binding site for residue GOL A 1651

Chain	Residue
A	THR1175
A	GLN1176
A	ARG1221
A	HOH1722
A	HOH1925

site_id	AH7
Number of Residues	9
Details	binding site for residue GOL A 1652

Chain	Residue
A	GLY278
A	ARG569
A	ILE1068
A	ASP1069
A	ASP1074
A	ARG1079
A	HOH1839
A	HOH2069
A	HOH2660

site_id	AH8
Number of Residues	9
Details	binding site for residue GOL A 1653

Chain	Residue
A	ASP250
A	TYR251
A	GLU264
A	GLU1007
A	HOH1978
A	HOH2028
A	HOH2456
A	HOH2602
A	HOH2927

site_id	AH9
Number of Residues	4
Details	binding site for residue GOL A 1654

Chain	Residue
A	GLN29
A	HIS31
A	SER117
A	HOH1741

site_id	AI1
Number of Residues	5
Details	binding site for residue GOL A 1655

Chain	Residue
A	PRO1015
A	ASN1018
A	HOH1810
A	HOH2105
A	HOH2477

site_id	AI2
Number of Residues	4
Details	binding site for residue GOL A 1656

Chain	Residue
A	SER214
A	GLU215
A	LYS220
A	HOH1963

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	CYS1135

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	HIS1260
A	GLU1262

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY307

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	THR386
A	ALA678
A	SER886

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419, ECO:0000269\|PubMed:15301531, ECO:0000269\|PubMed:22683785, ECO:0000269\|PubMed:24223728

Chain	Residue	Details
A	ASP679
A	GLU718
A	ASN722
A	ASP884

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)