6LWR

Crystal structure of human NEIL1(K242) bound to duplex DNA containing a cleaved C:T mismatch

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003684	molecular_function	damaged DNA binding
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0006284	biological_process	base-excision repair
A	0008270	molecular_function	zinc ion binding
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0019104	molecular_function	DNA N-glycosylase activity
E	0003676	molecular_function	nucleic acid binding
E	0003684	molecular_function	damaged DNA binding
E	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
E	0006284	biological_process	base-excision repair
E	0008270	molecular_function	zinc ion binding
E	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
E	0019104	molecular_function	DNA N-glycosylase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000305

Chain	Residue	Details
A	PRO2
E	PRO2

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000305

Chain	Residue	Details
A	GLU3
E	GLU3

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: Proton donor; for beta-elimination activity => ECO:0000305

Chain	Residue	Details
A	LYS54
E	LYS54

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASN176
E	ASN176

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