6LW5
Crystal structure of the human formyl peptide receptor 2 in complex with WKYMVm
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0001774 | biological_process | microglial cell activation |
| A | 0002376 | biological_process | immune system process |
| A | 0002430 | biological_process | complement receptor mediated signaling pathway |
| A | 0002768 | biological_process | immune response-regulating cell surface receptor signaling pathway |
| A | 0004875 | molecular_function | complement receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004982 | molecular_function | N-formyl peptide receptor activity |
| A | 0005124 | molecular_function | scavenger receptor binding |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006898 | biological_process | receptor-mediated endocytosis |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007154 | biological_process | cell communication |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0023052 | biological_process | signaling |
| A | 0032930 | biological_process | positive regulation of superoxide anion generation |
| A | 0035579 | cellular_component | specific granule membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0038024 | molecular_function | cargo receptor activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0045087 | biological_process | innate immune response |
| A | 0045089 | biological_process | positive regulation of innate immune response |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048143 | biological_process | astrocyte activation |
| A | 0050728 | biological_process | negative regulation of inflammatory response |
| A | 0050766 | biological_process | positive regulation of phagocytosis |
| A | 0050786 | molecular_function | RAGE receptor binding |
| A | 0050918 | biological_process | positive chemotaxis |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0070821 | cellular_component | tertiary granule membrane |
| A | 0090026 | biological_process | positive regulation of monocyte chemotaxis |
| A | 0097187 | biological_process | dentinogenesis |
| A | 0101003 | cellular_component | ficolin-1-rich granule membrane |
| A | 1904646 | biological_process | cellular response to amyloid-beta |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CLR A 1201 |
| Chain | Residue |
| A | ILE203 |
| A | SER215 |
| A | ILE219 |
| A | LEU262 |
| A | VAL266 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CLR A 1202 |
| Chain | Residue |
| A | VAL147 |
| A | TRP150 |
| A | VAL24 |
| A | ASN66 |
| A | MET143 |
| A | ILE146 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSVfLIGFIALDRCIcV |
| Chain | Residue | Details |
| A | GLY111-VAL127 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 13 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 77 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
