6LTS

Crystal structure of Thermus thermophilus transcription initiation complex comprising a truncated sigma finger

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0006351	biological_process	DNA-templated transcription
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0006351	biological_process	DNA-templated transcription
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0034062	molecular_function	5'-3' RNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0034062	molecular_function	5'-3' RNA polymerase activity
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005737	cellular_component	cytoplasm
F	0006352	biological_process	DNA-templated transcription initiation
F	0006355	biological_process	regulation of DNA-templated transcription
F	0010468	biological_process	regulation of gene expression
F	0016987	molecular_function	sigma factor activity
F	2000142	biological_process	regulation of DNA-templated transcription initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG B 2001

Chain	Residue
B	ASP183
B	ASP191
B	ASP193

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 2001

Chain	Residue
D	CYS1112
D	CYS1194
D	CYS1201
D	CYS1204

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN D 2002

Chain	Residue
D	CYS73
D	CYS76
D	CYS58
D	CYS60

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG D 2003

Chain	Residue
D	ASP739
D	ASP741
D	ASP743

---

site_id	AC5
Number of Residues	2
Details	binding site for residue MG D 2004

Chain	Residue
B	ASP168
D	LYS840

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG D 2005

Chain	Residue
D	TRP897
D	GLU898
D	ILE900

---

site_id	AC7
Number of Residues	3
Details	binding site for residue MG F 2001

Chain	Residue
F	ALA292
F	GLY296
F	TRP299

---

Functional Information from PROSITE/UniProt

site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TleEVGaffgVTrerIrQIEnkaLrkL

Chain	Residue	Details
F	THR382-LEU408

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL

Chain	Residue	Details
F	LEU187-LEU194

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---