6LTQ

Crystal structure of pyrrolidone carboxyl peptidase from thermophilic keratin degrading bacterium Fervidobacterium islandicum AW-1 (FiPcp)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0016920	molecular_function	pyroglutamyl-peptidase activity
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0016920	molecular_function	pyroglutamyl-peptidase activity
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0016920	molecular_function	pyroglutamyl-peptidase activity
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0016920	molecular_function	pyroglutamyl-peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 301

Chain	Residue
A	ARG35
A	ARG39
A	LYS42
A	LEU203
A	HOH404
A	HOH445
D	LYS61
D	GLU64

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 302

Chain	Residue
A	LYS141
A	ASN216
A	GLU219
A	LEU137

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 303

Chain	Residue
A	PHE25
A	HIS104
A	TYR154

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 304

Chain	Residue
A	GLY193
A	LYS194
A	HOH491
A	HOH506
A	HOH566
C	HIS104

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL B 301

Chain	Residue
B	SER102
B	LYS103
B	HIS104
B	HOH440
D	GOL301

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL B 302

Chain	Residue
B	GLN83
B	TYR154
B	OCS156
B	HIS180
B	HOH429

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL B 303

Chain	Residue
B	LEU53
B	VAL65
B	HOH405
B	HOH416
B	HOH446

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL B 304

Chain	Residue
B	GLY193
B	LYS194
D	LYS103
D	HIS104
D	HOH411

---

site_id	AC9
Number of Residues	9
Details	binding site for residue 1PE B 305

Chain	Residue
B	LEU137
B	LYS140
B	LYS141
B	ASN216
D	GLU23
D	PRO24
D	GLU28
D	LYS29
D	MET34

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL C 301

Chain	Residue
C	TYR59
C	THR63
C	ILE117
C	GLU158
C	HOH482
C	HOH499

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL C 302

Chain	Residue
C	ARG35
C	ARG39
C	LYS42
C	HOH420

---

site_id	AD3
Number of Residues	5
Details	binding site for residue GOL C 303

Chain	Residue
A	HIS104
C	GLY193
C	LYS194
C	HOH431
C	HOH512

---

site_id	AD4
Number of Residues	8
Details	binding site for residue GOL C 304

Chain	Residue
C	HIS104
C	TYR154
C	GOL305
C	HOH401
C	HOH407
C	HOH442
C	HOH469
C	HOH475

---

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL C 305

Chain	Residue
C	ARG91
C	GLY152
C	HIS180
C	GOL304
C	HOH405
C	HOH469

---

site_id	AD6
Number of Residues	3
Details	binding site for residue GOL C 306

Chain	Residue
C	LYS141
C	LYS208
C	ARG211

---

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL D 301

Chain	Residue
B	LYS103
B	HIS104
B	GOL301
D	GLY193
D	LYS194

---

site_id	AD8
Number of Residues	1
Details	binding site for residue GOL D 302

Chain	Residue
D	LYS141

---

site_id	AD9
Number of Residues	2
Details	binding site for residue GOL D 303

Chain	Residue
D	HIS104
D	HOH452

---

site_id	AE1
Number of Residues	4
Details	binding site for residue GOL D 304

Chain	Residue
D	THR63
D	ILE117
D	GLU158
D	HOH407

---

Functional Information from PROSITE/UniProt

site_id	PS01334
Number of Residues	15
Details	PYRASE_CYS Pyrrolidone-carboxylate peptidase cysteine active site. IpAfVSyTAGqYICN

Chain	Residue	Details
A	ILE143-ASN157

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