6LRT
Crystal structure of isocitrate lyase (Caur_3889) from Chloroflexus aurantiacus in complex with isocitrate and manganese ion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004451 | molecular_function | isocitrate lyase activity |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004451 | molecular_function | isocitrate lyase activity |
| D | 0006097 | biological_process | glyoxylate cycle |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004451 | molecular_function | isocitrate lyase activity |
| G | 0006097 | biological_process | glyoxylate cycle |
| G | 0006099 | biological_process | tricarboxylic acid cycle |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019752 | biological_process | carboxylic acid metabolic process |
| G | 0046872 | molecular_function | metal ion binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004451 | molecular_function | isocitrate lyase activity |
| J | 0006097 | biological_process | glyoxylate cycle |
| J | 0006099 | biological_process | tricarboxylic acid cycle |
| J | 0016829 | molecular_function | lyase activity |
| J | 0019752 | biological_process | carboxylic acid metabolic process |
| J | 0046872 | molecular_function | metal ion binding |
| M | 0003824 | molecular_function | catalytic activity |
| M | 0004451 | molecular_function | isocitrate lyase activity |
| M | 0006097 | biological_process | glyoxylate cycle |
| M | 0006099 | biological_process | tricarboxylic acid cycle |
| M | 0016829 | molecular_function | lyase activity |
| M | 0019752 | biological_process | carboxylic acid metabolic process |
| M | 0046872 | molecular_function | metal ion binding |
| P | 0003824 | molecular_function | catalytic activity |
| P | 0004451 | molecular_function | isocitrate lyase activity |
| P | 0006097 | biological_process | glyoxylate cycle |
| P | 0006099 | biological_process | tricarboxylic acid cycle |
| P | 0016829 | molecular_function | lyase activity |
| P | 0019752 | biological_process | carboxylic acid metabolic process |
| P | 0046872 | molecular_function | metal ion binding |
| S | 0003824 | molecular_function | catalytic activity |
| S | 0004451 | molecular_function | isocitrate lyase activity |
| S | 0006097 | biological_process | glyoxylate cycle |
| S | 0006099 | biological_process | tricarboxylic acid cycle |
| S | 0016829 | molecular_function | lyase activity |
| S | 0019752 | biological_process | carboxylic acid metabolic process |
| S | 0046872 | molecular_function | metal ion binding |
| V | 0003824 | molecular_function | catalytic activity |
| V | 0004451 | molecular_function | isocitrate lyase activity |
| V | 0006097 | biological_process | glyoxylate cycle |
| V | 0006099 | biological_process | tricarboxylic acid cycle |
| V | 0016829 | molecular_function | lyase activity |
| V | 0019752 | biological_process | carboxylic acid metabolic process |
| V | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ICT A 501 |
| Chain | Residue |
| A | TYR85 |
| A | ARG223 |
| A | GLU280 |
| A | ASN308 |
| A | SER310 |
| A | SER312 |
| A | THR342 |
| A | LEU343 |
| A | MN503 |
| A | SER87 |
| A | GLY88 |
| A | TRP89 |
| A | ASP104 |
| A | ASP148 |
| A | CYS186 |
| A | GLY187 |
| A | HIS188 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ARG125 |
| A | GLN129 |
| G | ARG35 |
| G | GLN39 |
| G | ILE40 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MN A 503 |
| Chain | Residue |
| A | ASP148 |
| A | LYS184 |
| A | ICT501 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue ICT D 501 |
| Chain | Residue |
| D | TYR85 |
| D | SER87 |
| D | GLY88 |
| D | TRP89 |
| D | ASP148 |
| D | CYS186 |
| D | GLY187 |
| D | HIS188 |
| D | ARG223 |
| D | GLU280 |
| D | ASN308 |
| D | SER310 |
| D | SER312 |
| D | THR342 |
| D | LEU343 |
| D | MN503 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| D | SER182 |
| D | GLU183 |
| G | GLY154 |
| G | ALA181 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MN D 503 |
| Chain | Residue |
| D | TRP89 |
| D | ASP104 |
| D | ASP148 |
| D | ICT501 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue ICT G 501 |
| Chain | Residue |
| G | TYR85 |
| G | SER87 |
| G | GLY88 |
| G | TRP89 |
| G | ASP148 |
| G | CYS186 |
| G | GLY187 |
| G | HIS188 |
| G | ARG223 |
| G | GLU280 |
| G | ASN308 |
| G | SER310 |
| G | SER312 |
| G | THR342 |
| G | LEU343 |
| G | MN504 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL G 502 |
| Chain | Residue |
| D | ASN158 |
| G | ALA98 |
| G | LEU107 |
| G | PRO109 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL G 503 |
| Chain | Residue |
| G | SER13 |
| G | TRP14 |
| G | ASP212 |
| G | PRO217 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MN G 504 |
| Chain | Residue |
| G | ASP104 |
| G | ASP148 |
| G | LYS184 |
| G | ICT501 |
| site_id | AD2 |
| Number of Residues | 16 |
| Details | binding site for residue ICT J 501 |
| Chain | Residue |
| J | TYR85 |
| J | SER87 |
| J | GLY88 |
| J | TRP89 |
| J | ASP148 |
| J | CYS186 |
| J | GLY187 |
| J | HIS188 |
| J | ARG223 |
| J | GLU280 |
| J | ASN308 |
| J | SER310 |
| J | SER312 |
| J | THR342 |
| J | LEU343 |
| J | MN504 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL J 502 |
| Chain | Residue |
| J | GLU391 |
| G | MET101 |
| J | LYS78 |
| J | ILE130 |
| J | TYR131 |
| J | TRP141 |
| J | ARG390 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue GOL J 503 |
| Chain | Residue |
| J | GLN402 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MN J 504 |
| Chain | Residue |
| J | ASP104 |
| J | ASP148 |
| J | LYS184 |
| J | ICT501 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue ICT M 501 |
| Chain | Residue |
| M | TYR85 |
| M | SER87 |
| M | GLY88 |
| M | TRP89 |
| M | ASP148 |
| M | CYS186 |
| M | GLY187 |
| M | HIS188 |
| M | ARG223 |
| M | GLU280 |
| M | ASN308 |
| M | SER310 |
| M | SER312 |
| M | THR342 |
| M | MN502 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue MN M 502 |
| Chain | Residue |
| M | ASP104 |
| M | ASP148 |
| M | LYS184 |
| M | ICT501 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for residue ICT P 501 |
| Chain | Residue |
| P | TYR85 |
| P | SER87 |
| P | GLY88 |
| P | TRP89 |
| P | ASP148 |
| P | CYS186 |
| P | GLY187 |
| P | HIS188 |
| P | ARG223 |
| P | GLU280 |
| P | ASN308 |
| P | SER310 |
| P | SER312 |
| P | THR342 |
| P | LEU343 |
| P | MN503 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL P 502 |
| Chain | Residue |
| P | ARG35 |
| P | VAL38 |
| P | ILE40 |
| P | VAL213 |
| V | ARG125 |
| V | GLN129 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue MN P 503 |
| Chain | Residue |
| P | GLY88 |
| P | TRP89 |
| P | ASP104 |
| P | ASP148 |
| P | ICT501 |
| site_id | AE2 |
| Number of Residues | 16 |
| Details | binding site for residue ICT S 501 |
| Chain | Residue |
| S | TYR85 |
| S | SER87 |
| S | TRP89 |
| S | ASP104 |
| S | ASP148 |
| S | CYS186 |
| S | GLY187 |
| S | HIS188 |
| S | ARG223 |
| S | TRP278 |
| S | GLU280 |
| S | ASN308 |
| S | SER310 |
| S | SER312 |
| S | THR342 |
| S | MN505 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL S 502 |
| Chain | Residue |
| P | ASN158 |
| S | LEU107 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL S 503 |
| Chain | Residue |
| S | SER13 |
| S | TRP14 |
| S | ASP212 |
| S | PRO217 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL S 504 |
| Chain | Residue |
| M | ARG125 |
| M | GLN129 |
| S | ARG35 |
| S | GLN39 |
| S | ILE40 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue MN S 505 |
| Chain | Residue |
| S | ASP148 |
| S | LYS184 |
| S | ARG223 |
| S | ICT501 |
| site_id | AE7 |
| Number of Residues | 16 |
| Details | binding site for residue ICT V 501 |
| Chain | Residue |
| V | TYR85 |
| V | SER87 |
| V | GLY88 |
| V | TRP89 |
| V | ASP148 |
| V | CYS186 |
| V | GLY187 |
| V | HIS188 |
| V | ARG223 |
| V | GLU280 |
| V | ASN308 |
| V | SER310 |
| V | SER312 |
| V | THR342 |
| V | LEU343 |
| V | MN504 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL V 502 |
| Chain | Residue |
| M | GLU161 |
| V | TYR102 |
| V | LEU107 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL V 503 |
| Chain | Residue |
| V | GLU50 |
| V | TRP53 |
| V | ASN54 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue MN V 504 |
| Chain | Residue |
| V | ASP104 |
| V | ASP148 |
| V | LYS184 |
| V | ICT501 |
Functional Information from PROSITE/UniProt
| site_id | PS00161 |
| Number of Residues | 6 |
| Details | ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHM |
| Chain | Residue | Details |
| A | LYS184-MET189 |
