Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LR3

Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0007165	biological_process	signal transduction
A	0016853	molecular_function	isomerase activity
A	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0005125	molecular_function	cytokine activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0007165	biological_process	signal transduction
B	0016853	molecular_function	isomerase activity
B	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0005125	molecular_function	cytokine activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0007165	biological_process	signal transduction
C	0016853	molecular_function	isomerase activity
C	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0005125	molecular_function	cytokine activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007165	biological_process	signal transduction
D	0016853	molecular_function	isomerase activity
D	0050178	molecular_function	phenylpyruvate tautomerase activity
E	0005125	molecular_function	cytokine activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0007165	biological_process	signal transduction
E	0016853	molecular_function	isomerase activity
E	0050178	molecular_function	phenylpyruvate tautomerase activity
F	0005125	molecular_function	cytokine activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0007165	biological_process	signal transduction
F	0016853	molecular_function	isomerase activity
F	0050178	molecular_function	phenylpyruvate tautomerase activity
G	0005125	molecular_function	cytokine activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0007165	biological_process	signal transduction
G	0016853	molecular_function	isomerase activity
G	0050178	molecular_function	phenylpyruvate tautomerase activity
H	0005125	molecular_function	cytokine activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0007165	biological_process	signal transduction
H	0016853	molecular_function	isomerase activity
H	0050178	molecular_function	phenylpyruvate tautomerase activity
I	0005125	molecular_function	cytokine activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0007165	biological_process	signal transduction
I	0016853	molecular_function	isomerase activity
I	0050178	molecular_function	phenylpyruvate tautomerase activity
J	0005125	molecular_function	cytokine activity
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0007165	biological_process	signal transduction
J	0016853	molecular_function	isomerase activity
J	0050178	molecular_function	phenylpyruvate tautomerase activity
K	0005125	molecular_function	cytokine activity
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0007165	biological_process	signal transduction
K	0016853	molecular_function	isomerase activity
K	0050178	molecular_function	phenylpyruvate tautomerase activity
L	0005125	molecular_function	cytokine activity
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0007165	biological_process	signal transduction
L	0016853	molecular_function	isomerase activity
L	0050178	molecular_function	phenylpyruvate tautomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG98
A	ILE100
A	HOH301
C	ARG98
C	ILE100
D	ARG98
D	ILE100

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 D 201

Chain	Residue
C	HOH259
D	ARG43
D	HOH371
D	HOH379
A	ARG43
C	ARG43

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 B 201

Chain	Residue
B	ARG98
B	ILE100
B	HOH302
B	HOH388
E	ARG98
E	ILE100
F	ARG98
F	ILE100

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 F 201

Chain	Residue
B	ARG43
E	ARG43
F	ARG43
F	HOH329
F	HOH361
F	HOH369

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 G 201

Chain	Residue
G	ARG43
G	HOH353
G	HOH363
G	HOH383
H	ARG43
I	ARG43

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 G 202

Chain	Residue
G	ARG98
G	ILE100
G	HOH406
H	ARG98
H	ILE100
I	ARG98
I	ILE100

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 J 201

Chain	Residue
J	ARG43
J	HOH361
J	HOH371
K	ARG43
L	ARG43
L	HOH285

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 J 202

Chain	Residue
J	ARG98
J	ILE100
J	HOH312
J	HOH396
K	ARG98
K	ILE100
L	ARG98
L	ILE100

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)