6LPJ

A2AR crystallized in EROCOC17+4, LCP-SFX at 277 K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue ZMA A 2401

Chain	Residue
A	PHE168
A	HOH2517
A	HOH2546
A	HOH2550
A	HOH2572
A	GLU169
A	MET177
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	MET270
A	ILE274

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 2402

Chain	Residue
A	ASP52
A	SER91
A	HOH2525
A	HOH2547
A	HOH2581

---

site_id	AC3
Number of Residues	7
Details	binding site for residue CLR A 2403

Chain	Residue
A	ALA72
A	ALA73
A	ILE80
A	CLR2405
A	TRD2422
A	ER02423
A	MYS2426

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CLR A 2404

Chain	Residue
A	PRO248
A	CYS262
A	SER263
A	HOH2555

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CLR A 2405

Chain	Residue
A	CYS254
A	CLR2403
A	MYS2409
A	ER02423
A	HOH2506

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MYS A 2409

Chain	Residue
A	CLR2405
A	ER02423
A	HOH2555

---

site_id	AC7
Number of Residues	3
Details	binding site for residue 8K6 A 2410

Chain	Residue
A	SER6
A	SER7
A	THR11

---

site_id	AC8
Number of Residues	1
Details	binding site for residue D10 A 2411

Chain	Residue
A	ILE124

---

site_id	AC9
Number of Residues	3
Details	binding site for residue MYS A 2414

Chain	Residue
A	TYR290
A	ER02416
A	8K62419

---

site_id	AD1
Number of Residues	2
Details	binding site for residue UND A 2415

Chain	Residue
A	SER7
A	TRP29

---

site_id	AD2
Number of Residues	9
Details	binding site for residue ER0 A 2416

Chain	Residue
A	PRO2
A	GLY5
A	SER6
A	TRP268
A	TYR271
A	LEU272
A	THR279
A	MYS2414
A	HOH2504

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MYS A 2417

Chain	Residue
A	PHE180
A	MYS2424

---

site_id	AD4
Number of Residues	1
Details	binding site for residue 8K6 A 2419

Chain	Residue
A	MYS2414

---

site_id	AD5
Number of Residues	2
Details	binding site for residue OCT A 2421

Chain	Residue
A	TYR179
A	PHE257

---

site_id	AD6
Number of Residues	1
Details	binding site for residue TRD A 2422

Chain	Residue
A	CLR2403

---

site_id	AD7
Number of Residues	8
Details	binding site for residue ER0 A 2423

Chain	Residue
A	GLY56
A	VAL57
A	CYS71
A	GLN163
A	CLR2403
A	CLR2405
A	MYS2409
A	HOH2528

---

site_id	AD8
Number of Residues	4
Details	binding site for residue MYS A 2424

Chain	Residue
A	MET140
A	LEU141
A	TYR179
A	MYS2417

---

site_id	AD9
Number of Residues	2
Details	binding site for residue MYS A 2426

Chain	Residue
A	PHE258
A	CLR2403

---

site_id	AE1
Number of Residues	1
Details	binding site for residue TRD A 2427

Chain	Residue
A	TYR43

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

---

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

---

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU235-PHE258

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	SER277
A	HIS278

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN154

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	GLU1008
A	GLN1103

---