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6LOJ

The complex structure of IpaH9.8-LRR and hGBP1

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001530molecular_functionlipopolysaccharide binding
B0003779molecular_functionactin binding
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0004382molecular_functionGDP phosphatase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0012506cellular_componentvesicle membrane
B0015629cellular_componentactin cytoskeleton
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0019899molecular_functionenzyme binding
B0019955molecular_functioncytokine binding
B0030507molecular_functionspectrin binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032703biological_processnegative regulation of interleukin-2 production
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042832biological_processdefense response to protozoan
B0045087biological_processinnate immune response
B0050848biological_processregulation of calcium-mediated signaling
B0050860biological_processnegative regulation of T cell receptor signaling pathway
B0051607biological_processdefense response to virus
B0051715biological_processcytolysis in another organism
B0051879molecular_functionHsp90 protein binding
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0072665biological_processprotein localization to vacuole
B0106139cellular_componentsymbiont cell surface
B0140639biological_processpositive regulation of pyroptosis
B0160075biological_processnon-canonical inflammasome complex assembly
B1900025biological_processnegative regulation of substrate adhesion-dependent cell spreading
B1903076biological_processregulation of protein localization to plasma membrane
B1903077biological_processnegative regulation of protein localization to plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue GDP B 601
ChainResidue
BTYR47
BASP184
BALA248
BARG48
BTHR49
BGLY50
BLYS51
BSER52
BTHR98
BGLU99
BGLY100

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10676968, ECO:0000269|PubMed:10970849, ECO:0000269|PubMed:16511497, ECO:0007744|PDB:1F5N, ECO:0007744|PDB:2B8W, ECO:0007744|PDB:2B92, ECO:0007744|PDB:2D4H
ChainResidueDetails
BGLY45
BLEU67

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10676968, ECO:0000269|PubMed:10970849, ECO:0007744|PDB:1F5N
ChainResidueDetails
BASP97

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PIM1 => ECO:0000269|PubMed:37797010
ChainResidueDetails
BSER156

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000305|PubMed:8830800
ChainResidueDetails
BCYS589

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PIM1 => ECO:0000269|PubMed:37797010
ChainResidueDetails
BTHR590

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: S-farnesyl cysteine => ECO:0000269|PubMed:29144452, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32510692, ECO:0000269|PubMed:8830800
ChainResidueDetails
BCYS589

site_idSWS_FT_FI7
Number of Residues9
DetailsCROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:29144452
ChainResidueDetails
BLYS207
BLYS209
BLYS210
BLYS382
BLYS562
BLYS567
BLYS573
BLYS587

219869

PDB entries from 2024-05-15

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