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6LLC

Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0002931biological_processresponse to ischemia
A0003723molecular_functionRNA binding
A0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
A0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
A0004784molecular_functionsuperoxide dismutase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006116biological_processNADH oxidation
A0006743biological_processubiquinone metabolic process
A0006801biological_processsuperoxide metabolic process
A0006805biological_processxenobiotic metabolic process
A0006809biological_processnitric oxide biosynthetic process
A0006979biological_processresponse to oxidative stress
A0007271biological_processsynaptic transmission, cholinergic
A0007584biological_processresponse to nutrient
A0008753molecular_functionNADPH dehydrogenase (quinone) activity
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0009725biological_processresponse to hormone
A0009743biological_processresponse to carbohydrate
A0014070biological_processresponse to organic cyclic compound
A0014075biological_processresponse to amine
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0030163biological_processprotein catabolic process
A0030425cellular_componentdendrite
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0033574biological_processresponse to testosterone
A0034599biological_processcellular response to oxidative stress
A0042177biological_processnegative regulation of protein catabolic process
A0042360biological_processvitamin E metabolic process
A0042373biological_processvitamin K metabolic process
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043279biological_processresponse to alkaloid
A0043525biological_processpositive regulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0045454biological_processcell redox homeostasis
A0045471biological_processresponse to ethanol
A0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
A0051602biological_processresponse to electrical stimulus
A0070301biological_processcellular response to hydrogen peroxide
A0070995biological_processNADPH oxidation
A0071248biological_processcellular response to metal ion
A0110076biological_processnegative regulation of ferroptosis
A1904772biological_processresponse to tetrachloromethane
A1904844biological_processresponse to L-glutamine
A1904880biological_processresponse to hydrogen sulfide
A1905395biological_processresponse to flavonoid
B0000209biological_processprotein polyubiquitination
B0002931biological_processresponse to ischemia
B0003723molecular_functionRNA binding
B0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
B0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
B0004784molecular_functionsuperoxide dismutase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006116biological_processNADH oxidation
B0006743biological_processubiquinone metabolic process
B0006801biological_processsuperoxide metabolic process
B0006805biological_processxenobiotic metabolic process
B0006809biological_processnitric oxide biosynthetic process
B0006979biological_processresponse to oxidative stress
B0007271biological_processsynaptic transmission, cholinergic
B0007584biological_processresponse to nutrient
B0008753molecular_functionNADPH dehydrogenase (quinone) activity
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0009725biological_processresponse to hormone
B0009743biological_processresponse to carbohydrate
B0014070biological_processresponse to organic cyclic compound
B0014075biological_processresponse to amine
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0030163biological_processprotein catabolic process
B0030425cellular_componentdendrite
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0033574biological_processresponse to testosterone
B0034599biological_processcellular response to oxidative stress
B0042177biological_processnegative regulation of protein catabolic process
B0042360biological_processvitamin E metabolic process
B0042373biological_processvitamin K metabolic process
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043066biological_processnegative regulation of apoptotic process
B0043279biological_processresponse to alkaloid
B0043525biological_processpositive regulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0045202cellular_componentsynapse
B0045454biological_processcell redox homeostasis
B0045471biological_processresponse to ethanol
B0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
B0051602biological_processresponse to electrical stimulus
B0070301biological_processcellular response to hydrogen peroxide
B0070995biological_processNADPH oxidation
B0071248biological_processcellular response to metal ion
B0110076biological_processnegative regulation of ferroptosis
B1904772biological_processresponse to tetrachloromethane
B1904844biological_processresponse to L-glutamine
B1904880biological_processresponse to hydrogen sulfide
B1905395biological_processresponse to flavonoid
C0000209biological_processprotein polyubiquitination
C0002931biological_processresponse to ischemia
C0003723molecular_functionRNA binding
C0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
C0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
C0004784molecular_functionsuperoxide dismutase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006116biological_processNADH oxidation
C0006743biological_processubiquinone metabolic process
C0006801biological_processsuperoxide metabolic process
C0006805biological_processxenobiotic metabolic process
C0006809biological_processnitric oxide biosynthetic process
C0006979biological_processresponse to oxidative stress
C0007271biological_processsynaptic transmission, cholinergic
C0007584biological_processresponse to nutrient
C0008753molecular_functionNADPH dehydrogenase (quinone) activity
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0009725biological_processresponse to hormone
C0009743biological_processresponse to carbohydrate
C0014070biological_processresponse to organic cyclic compound
C0014075biological_processresponse to amine
C0016491molecular_functionoxidoreductase activity
C0019430biological_processremoval of superoxide radicals
C0030163biological_processprotein catabolic process
C0030425cellular_componentdendrite
C0032355biological_processresponse to estradiol
C0032496biological_processresponse to lipopolysaccharide
C0033574biological_processresponse to testosterone
C0034599biological_processcellular response to oxidative stress
C0042177biological_processnegative regulation of protein catabolic process
C0042360biological_processvitamin E metabolic process
C0042373biological_processvitamin K metabolic process
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043066biological_processnegative regulation of apoptotic process
C0043279biological_processresponse to alkaloid
C0043525biological_processpositive regulation of neuron apoptotic process
C0045087biological_processinnate immune response
C0045202cellular_componentsynapse
C0045454biological_processcell redox homeostasis
C0045471biological_processresponse to ethanol
C0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
C0051602biological_processresponse to electrical stimulus
C0070301biological_processcellular response to hydrogen peroxide
C0070995biological_processNADPH oxidation
C0071248biological_processcellular response to metal ion
C0110076biological_processnegative regulation of ferroptosis
C1904772biological_processresponse to tetrachloromethane
C1904844biological_processresponse to L-glutamine
C1904880biological_processresponse to hydrogen sulfide
C1905395biological_processresponse to flavonoid
D0000209biological_processprotein polyubiquitination
D0002931biological_processresponse to ischemia
D0003723molecular_functionRNA binding
D0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
D0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
D0004784molecular_functionsuperoxide dismutase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006116biological_processNADH oxidation
D0006743biological_processubiquinone metabolic process
D0006801biological_processsuperoxide metabolic process
D0006805biological_processxenobiotic metabolic process
D0006809biological_processnitric oxide biosynthetic process
D0006979biological_processresponse to oxidative stress
D0007271biological_processsynaptic transmission, cholinergic
D0007584biological_processresponse to nutrient
D0008753molecular_functionNADPH dehydrogenase (quinone) activity
D0009410biological_processresponse to xenobiotic stimulus
D0009636biological_processresponse to toxic substance
D0009725biological_processresponse to hormone
D0009743biological_processresponse to carbohydrate
D0014070biological_processresponse to organic cyclic compound
D0014075biological_processresponse to amine
D0016491molecular_functionoxidoreductase activity
D0019430biological_processremoval of superoxide radicals
D0030163biological_processprotein catabolic process
D0030425cellular_componentdendrite
D0032355biological_processresponse to estradiol
D0032496biological_processresponse to lipopolysaccharide
D0033574biological_processresponse to testosterone
D0034599biological_processcellular response to oxidative stress
D0042177biological_processnegative regulation of protein catabolic process
D0042360biological_processvitamin E metabolic process
D0042373biological_processvitamin K metabolic process
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043066biological_processnegative regulation of apoptotic process
D0043279biological_processresponse to alkaloid
D0043525biological_processpositive regulation of neuron apoptotic process
D0045087biological_processinnate immune response
D0045202cellular_componentsynapse
D0045454biological_processcell redox homeostasis
D0045471biological_processresponse to ethanol
D0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
D0051602biological_processresponse to electrical stimulus
D0070301biological_processcellular response to hydrogen peroxide
D0070995biological_processNADPH oxidation
D0071248biological_processcellular response to metal ion
D0110076biological_processnegative regulation of ferroptosis
D1904772biological_processresponse to tetrachloromethane
D1904844biological_processresponse to L-glutamine
D1904880biological_processresponse to hydrogen sulfide
D1905395biological_processresponse to flavonoid
E0000209biological_processprotein polyubiquitination
E0002931biological_processresponse to ischemia
E0003723molecular_functionRNA binding
E0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
E0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
E0004784molecular_functionsuperoxide dismutase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006116biological_processNADH oxidation
E0006743biological_processubiquinone metabolic process
E0006801biological_processsuperoxide metabolic process
E0006805biological_processxenobiotic metabolic process
E0006809biological_processnitric oxide biosynthetic process
E0006979biological_processresponse to oxidative stress
E0007271biological_processsynaptic transmission, cholinergic
E0007584biological_processresponse to nutrient
E0008753molecular_functionNADPH dehydrogenase (quinone) activity
E0009410biological_processresponse to xenobiotic stimulus
E0009636biological_processresponse to toxic substance
E0009725biological_processresponse to hormone
E0009743biological_processresponse to carbohydrate
E0014070biological_processresponse to organic cyclic compound
E0014075biological_processresponse to amine
E0016491molecular_functionoxidoreductase activity
E0019430biological_processremoval of superoxide radicals
E0030163biological_processprotein catabolic process
E0030425cellular_componentdendrite
E0032355biological_processresponse to estradiol
E0032496biological_processresponse to lipopolysaccharide
E0033574biological_processresponse to testosterone
E0034599biological_processcellular response to oxidative stress
E0042177biological_processnegative regulation of protein catabolic process
E0042360biological_processvitamin E metabolic process
E0042373biological_processvitamin K metabolic process
E0042802molecular_functionidentical protein binding
E0043025cellular_componentneuronal cell body
E0043066biological_processnegative regulation of apoptotic process
E0043279biological_processresponse to alkaloid
E0043525biological_processpositive regulation of neuron apoptotic process
E0045087biological_processinnate immune response
E0045202cellular_componentsynapse
E0045454biological_processcell redox homeostasis
E0045471biological_processresponse to ethanol
E0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
E0051602biological_processresponse to electrical stimulus
E0070301biological_processcellular response to hydrogen peroxide
E0070995biological_processNADPH oxidation
E0071248biological_processcellular response to metal ion
E0110076biological_processnegative regulation of ferroptosis
E1904772biological_processresponse to tetrachloromethane
E1904844biological_processresponse to L-glutamine
E1904880biological_processresponse to hydrogen sulfide
E1905395biological_processresponse to flavonoid
F0000209biological_processprotein polyubiquitination
F0002931biological_processresponse to ischemia
F0003723molecular_functionRNA binding
F0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
F0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
F0004784molecular_functionsuperoxide dismutase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006116biological_processNADH oxidation
F0006743biological_processubiquinone metabolic process
F0006801biological_processsuperoxide metabolic process
F0006805biological_processxenobiotic metabolic process
F0006809biological_processnitric oxide biosynthetic process
F0006979biological_processresponse to oxidative stress
F0007271biological_processsynaptic transmission, cholinergic
F0007584biological_processresponse to nutrient
F0008753molecular_functionNADPH dehydrogenase (quinone) activity
F0009410biological_processresponse to xenobiotic stimulus
F0009636biological_processresponse to toxic substance
F0009725biological_processresponse to hormone
F0009743biological_processresponse to carbohydrate
F0014070biological_processresponse to organic cyclic compound
F0014075biological_processresponse to amine
F0016491molecular_functionoxidoreductase activity
F0019430biological_processremoval of superoxide radicals
F0030163biological_processprotein catabolic process
F0030425cellular_componentdendrite
F0032355biological_processresponse to estradiol
F0032496biological_processresponse to lipopolysaccharide
F0033574biological_processresponse to testosterone
F0034599biological_processcellular response to oxidative stress
F0042177biological_processnegative regulation of protein catabolic process
F0042360biological_processvitamin E metabolic process
F0042373biological_processvitamin K metabolic process
F0042802molecular_functionidentical protein binding
F0043025cellular_componentneuronal cell body
F0043066biological_processnegative regulation of apoptotic process
F0043279biological_processresponse to alkaloid
F0043525biological_processpositive regulation of neuron apoptotic process
F0045087biological_processinnate immune response
F0045202cellular_componentsynapse
F0045454biological_processcell redox homeostasis
F0045471biological_processresponse to ethanol
F0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
F0051602biological_processresponse to electrical stimulus
F0070301biological_processcellular response to hydrogen peroxide
F0070995biological_processNADPH oxidation
F0071248biological_processcellular response to metal ion
F0110076biological_processnegative regulation of ferroptosis
F1904772biological_processresponse to tetrachloromethane
F1904844biological_processresponse to L-glutamine
F1904880biological_processresponse to hydrogen sulfide
F1905395biological_processresponse to flavonoid
G0000209biological_processprotein polyubiquitination
G0002931biological_processresponse to ischemia
G0003723molecular_functionRNA binding
G0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
G0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
G0004784molecular_functionsuperoxide dismutase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006116biological_processNADH oxidation
G0006743biological_processubiquinone metabolic process
G0006801biological_processsuperoxide metabolic process
G0006805biological_processxenobiotic metabolic process
G0006809biological_processnitric oxide biosynthetic process
G0006979biological_processresponse to oxidative stress
G0007271biological_processsynaptic transmission, cholinergic
G0007584biological_processresponse to nutrient
G0008753molecular_functionNADPH dehydrogenase (quinone) activity
G0009410biological_processresponse to xenobiotic stimulus
G0009636biological_processresponse to toxic substance
G0009725biological_processresponse to hormone
G0009743biological_processresponse to carbohydrate
G0014070biological_processresponse to organic cyclic compound
G0014075biological_processresponse to amine
G0016491molecular_functionoxidoreductase activity
G0019430biological_processremoval of superoxide radicals
G0030163biological_processprotein catabolic process
G0030425cellular_componentdendrite
G0032355biological_processresponse to estradiol
G0032496biological_processresponse to lipopolysaccharide
G0033574biological_processresponse to testosterone
G0034599biological_processcellular response to oxidative stress
G0042177biological_processnegative regulation of protein catabolic process
G0042360biological_processvitamin E metabolic process
G0042373biological_processvitamin K metabolic process
G0042802molecular_functionidentical protein binding
G0043025cellular_componentneuronal cell body
G0043066biological_processnegative regulation of apoptotic process
G0043279biological_processresponse to alkaloid
G0043525biological_processpositive regulation of neuron apoptotic process
G0045087biological_processinnate immune response
G0045202cellular_componentsynapse
G0045454biological_processcell redox homeostasis
G0045471biological_processresponse to ethanol
G0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
G0051602biological_processresponse to electrical stimulus
G0070301biological_processcellular response to hydrogen peroxide
G0070995biological_processNADPH oxidation
G0071248biological_processcellular response to metal ion
G0110076biological_processnegative regulation of ferroptosis
G1904772biological_processresponse to tetrachloromethane
G1904844biological_processresponse to L-glutamine
G1904880biological_processresponse to hydrogen sulfide
G1905395biological_processresponse to flavonoid
H0000209biological_processprotein polyubiquitination
H0002931biological_processresponse to ischemia
H0003723molecular_functionRNA binding
H0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
H0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
H0004784molecular_functionsuperoxide dismutase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006116biological_processNADH oxidation
H0006743biological_processubiquinone metabolic process
H0006801biological_processsuperoxide metabolic process
H0006805biological_processxenobiotic metabolic process
H0006809biological_processnitric oxide biosynthetic process
H0006979biological_processresponse to oxidative stress
H0007271biological_processsynaptic transmission, cholinergic
H0007584biological_processresponse to nutrient
H0008753molecular_functionNADPH dehydrogenase (quinone) activity
H0009410biological_processresponse to xenobiotic stimulus
H0009636biological_processresponse to toxic substance
H0009725biological_processresponse to hormone
H0009743biological_processresponse to carbohydrate
H0014070biological_processresponse to organic cyclic compound
H0014075biological_processresponse to amine
H0016491molecular_functionoxidoreductase activity
H0019430biological_processremoval of superoxide radicals
H0030163biological_processprotein catabolic process
H0030425cellular_componentdendrite
H0032355biological_processresponse to estradiol
H0032496biological_processresponse to lipopolysaccharide
H0033574biological_processresponse to testosterone
H0034599biological_processcellular response to oxidative stress
H0042177biological_processnegative regulation of protein catabolic process
H0042360biological_processvitamin E metabolic process
H0042373biological_processvitamin K metabolic process
H0042802molecular_functionidentical protein binding
H0043025cellular_componentneuronal cell body
H0043066biological_processnegative regulation of apoptotic process
H0043279biological_processresponse to alkaloid
H0043525biological_processpositive regulation of neuron apoptotic process
H0045087biological_processinnate immune response
H0045202cellular_componentsynapse
H0045454biological_processcell redox homeostasis
H0045471biological_processresponse to ethanol
H0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
H0051602biological_processresponse to electrical stimulus
H0070301biological_processcellular response to hydrogen peroxide
H0070995biological_processNADPH oxidation
H0071248biological_processcellular response to metal ion
H0110076biological_processnegative regulation of ferroptosis
H1904772biological_processresponse to tetrachloromethane
H1904844biological_processresponse to L-glutamine
H1904880biological_processresponse to hydrogen sulfide
H1905395biological_processresponse to flavonoid
I0000209biological_processprotein polyubiquitination
I0002931biological_processresponse to ischemia
I0003723molecular_functionRNA binding
I0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
I0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
I0004784molecular_functionsuperoxide dismutase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006116biological_processNADH oxidation
I0006743biological_processubiquinone metabolic process
I0006801biological_processsuperoxide metabolic process
I0006805biological_processxenobiotic metabolic process
I0006809biological_processnitric oxide biosynthetic process
I0006979biological_processresponse to oxidative stress
I0007271biological_processsynaptic transmission, cholinergic
I0007584biological_processresponse to nutrient
I0008753molecular_functionNADPH dehydrogenase (quinone) activity
I0009410biological_processresponse to xenobiotic stimulus
I0009636biological_processresponse to toxic substance
I0009725biological_processresponse to hormone
I0009743biological_processresponse to carbohydrate
I0014070biological_processresponse to organic cyclic compound
I0014075biological_processresponse to amine
I0016491molecular_functionoxidoreductase activity
I0019430biological_processremoval of superoxide radicals
I0030163biological_processprotein catabolic process
I0030425cellular_componentdendrite
I0032355biological_processresponse to estradiol
I0032496biological_processresponse to lipopolysaccharide
I0033574biological_processresponse to testosterone
I0034599biological_processcellular response to oxidative stress
I0042177biological_processnegative regulation of protein catabolic process
I0042360biological_processvitamin E metabolic process
I0042373biological_processvitamin K metabolic process
I0042802molecular_functionidentical protein binding
I0043025cellular_componentneuronal cell body
I0043066biological_processnegative regulation of apoptotic process
I0043279biological_processresponse to alkaloid
I0043525biological_processpositive regulation of neuron apoptotic process
I0045087biological_processinnate immune response
I0045202cellular_componentsynapse
I0045454biological_processcell redox homeostasis
I0045471biological_processresponse to ethanol
I0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
I0051602biological_processresponse to electrical stimulus
I0070301biological_processcellular response to hydrogen peroxide
I0070995biological_processNADPH oxidation
I0071248biological_processcellular response to metal ion
I0110076biological_processnegative regulation of ferroptosis
I1904772biological_processresponse to tetrachloromethane
I1904844biological_processresponse to L-glutamine
I1904880biological_processresponse to hydrogen sulfide
I1905395biological_processresponse to flavonoid
J0000209biological_processprotein polyubiquitination
J0002931biological_processresponse to ischemia
J0003723molecular_functionRNA binding
J0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
J0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
J0004784molecular_functionsuperoxide dismutase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006116biological_processNADH oxidation
J0006743biological_processubiquinone metabolic process
J0006801biological_processsuperoxide metabolic process
J0006805biological_processxenobiotic metabolic process
J0006809biological_processnitric oxide biosynthetic process
J0006979biological_processresponse to oxidative stress
J0007271biological_processsynaptic transmission, cholinergic
J0007584biological_processresponse to nutrient
J0008753molecular_functionNADPH dehydrogenase (quinone) activity
J0009410biological_processresponse to xenobiotic stimulus
J0009636biological_processresponse to toxic substance
J0009725biological_processresponse to hormone
J0009743biological_processresponse to carbohydrate
J0014070biological_processresponse to organic cyclic compound
J0014075biological_processresponse to amine
J0016491molecular_functionoxidoreductase activity
J0019430biological_processremoval of superoxide radicals
J0030163biological_processprotein catabolic process
J0030425cellular_componentdendrite
J0032355biological_processresponse to estradiol
J0032496biological_processresponse to lipopolysaccharide
J0033574biological_processresponse to testosterone
J0034599biological_processcellular response to oxidative stress
J0042177biological_processnegative regulation of protein catabolic process
J0042360biological_processvitamin E metabolic process
J0042373biological_processvitamin K metabolic process
J0042802molecular_functionidentical protein binding
J0043025cellular_componentneuronal cell body
J0043066biological_processnegative regulation of apoptotic process
J0043279biological_processresponse to alkaloid
J0043525biological_processpositive regulation of neuron apoptotic process
J0045087biological_processinnate immune response
J0045202cellular_componentsynapse
J0045454biological_processcell redox homeostasis
J0045471biological_processresponse to ethanol
J0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
J0051602biological_processresponse to electrical stimulus
J0070301biological_processcellular response to hydrogen peroxide
J0070995biological_processNADPH oxidation
J0071248biological_processcellular response to metal ion
J0110076biological_processnegative regulation of ferroptosis
J1904772biological_processresponse to tetrachloromethane
J1904844biological_processresponse to L-glutamine
J1904880biological_processresponse to hydrogen sulfide
J1905395biological_processresponse to flavonoid
K0000209biological_processprotein polyubiquitination
K0002931biological_processresponse to ischemia
K0003723molecular_functionRNA binding
K0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
K0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
K0004784molecular_functionsuperoxide dismutase activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0006116biological_processNADH oxidation
K0006743biological_processubiquinone metabolic process
K0006801biological_processsuperoxide metabolic process
K0006805biological_processxenobiotic metabolic process
K0006809biological_processnitric oxide biosynthetic process
K0006979biological_processresponse to oxidative stress
K0007271biological_processsynaptic transmission, cholinergic
K0007584biological_processresponse to nutrient
K0008753molecular_functionNADPH dehydrogenase (quinone) activity
K0009410biological_processresponse to xenobiotic stimulus
K0009636biological_processresponse to toxic substance
K0009725biological_processresponse to hormone
K0009743biological_processresponse to carbohydrate
K0014070biological_processresponse to organic cyclic compound
K0014075biological_processresponse to amine
K0016491molecular_functionoxidoreductase activity
K0019430biological_processremoval of superoxide radicals
K0030163biological_processprotein catabolic process
K0030425cellular_componentdendrite
K0032355biological_processresponse to estradiol
K0032496biological_processresponse to lipopolysaccharide
K0033574biological_processresponse to testosterone
K0034599biological_processcellular response to oxidative stress
K0042177biological_processnegative regulation of protein catabolic process
K0042360biological_processvitamin E metabolic process
K0042373biological_processvitamin K metabolic process
K0042802molecular_functionidentical protein binding
K0043025cellular_componentneuronal cell body
K0043066biological_processnegative regulation of apoptotic process
K0043279biological_processresponse to alkaloid
K0043525biological_processpositive regulation of neuron apoptotic process
K0045087biological_processinnate immune response
K0045202cellular_componentsynapse
K0045454biological_processcell redox homeostasis
K0045471biological_processresponse to ethanol
K0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
K0051602biological_processresponse to electrical stimulus
K0070301biological_processcellular response to hydrogen peroxide
K0070995biological_processNADPH oxidation
K0071248biological_processcellular response to metal ion
K0110076biological_processnegative regulation of ferroptosis
K1904772biological_processresponse to tetrachloromethane
K1904844biological_processresponse to L-glutamine
K1904880biological_processresponse to hydrogen sulfide
K1905395biological_processresponse to flavonoid
L0000209biological_processprotein polyubiquitination
L0002931biological_processresponse to ischemia
L0003723molecular_functionRNA binding
L0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
L0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
L0004784molecular_functionsuperoxide dismutase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0006116biological_processNADH oxidation
L0006743biological_processubiquinone metabolic process
L0006801biological_processsuperoxide metabolic process
L0006805biological_processxenobiotic metabolic process
L0006809biological_processnitric oxide biosynthetic process
L0006979biological_processresponse to oxidative stress
L0007271biological_processsynaptic transmission, cholinergic
L0007584biological_processresponse to nutrient
L0008753molecular_functionNADPH dehydrogenase (quinone) activity
L0009410biological_processresponse to xenobiotic stimulus
L0009636biological_processresponse to toxic substance
L0009725biological_processresponse to hormone
L0009743biological_processresponse to carbohydrate
L0014070biological_processresponse to organic cyclic compound
L0014075biological_processresponse to amine
L0016491molecular_functionoxidoreductase activity
L0019430biological_processremoval of superoxide radicals
L0030163biological_processprotein catabolic process
L0030425cellular_componentdendrite
L0032355biological_processresponse to estradiol
L0032496biological_processresponse to lipopolysaccharide
L0033574biological_processresponse to testosterone
L0034599biological_processcellular response to oxidative stress
L0042177biological_processnegative regulation of protein catabolic process
L0042360biological_processvitamin E metabolic process
L0042373biological_processvitamin K metabolic process
L0042802molecular_functionidentical protein binding
L0043025cellular_componentneuronal cell body
L0043066biological_processnegative regulation of apoptotic process
L0043279biological_processresponse to alkaloid
L0043525biological_processpositive regulation of neuron apoptotic process
L0045087biological_processinnate immune response
L0045202cellular_componentsynapse
L0045454biological_processcell redox homeostasis
L0045471biological_processresponse to ethanol
L0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
L0051602biological_processresponse to electrical stimulus
L0070301biological_processcellular response to hydrogen peroxide
L0070995biological_processNADPH oxidation
L0071248biological_processcellular response to metal ion
L0110076biological_processnegative regulation of ferroptosis
L1904772biological_processresponse to tetrachloromethane
L1904844biological_processresponse to L-glutamine
L1904880biological_processresponse to hydrogen sulfide
L1905395biological_processresponse to flavonoid
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue SO4 A 2303
ChainResidue
AALA197
AARG200
ALYS239

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 D 303
ChainResidue
DALA197
DARG200
DLYS239

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 F 2302
ChainResidue
HALA197
HARG200
ILYS239

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 J 303
ChainResidue
GLYS239
JALA197
JARG200

site_idAC5
Number of Residues7
Detailsbinding site for Di-peptide EHL B 2302 and MET B 131
ChainResidue
BTHR127
BALA130
BTYR132
BASP133
BLYS134
BGLY135
BPHE178

site_idAC6
Number of Residues5
Detailsbinding site for Di-peptide EHL D 301 and MET D 131
ChainResidue
DTHR127
DALA130
DTYR132
DASP133
DLYS134

site_idAC7
Number of Residues5
Detailsbinding site for Di-peptide EHL D 301 and MET D 131
ChainResidue
DTHR127
DALA130
DTYR132
DASP133
DLYS134

site_idAC8
Number of Residues15
Detailsbinding site for Di-peptide EHL E 2302 and MET C 131
ChainResidue
CTHR127
CALA130
CTYR132
CASP133
CLYS134
CGLY135
CILE160
CPHE178
CHOH2401
ETHR127
ETYR128
EALA130
ETYR132
EASP133
ELYS134

site_idAC9
Number of Residues15
Detailsbinding site for Di-peptide EHL E 2302 and MET C 131
ChainResidue
CTHR127
CALA130
CTYR132
CASP133
CLYS134
CGLY135
CILE160
CPHE178
CHOH2401
ETHR127
ETYR128
EALA130
ETYR132
EASP133
ELYS134

site_idAD1
Number of Residues6
Detailsbinding site for Di-peptide EHL H 301 and TYR H 128
ChainResidue
HTHR127
HALA129
HALA130
HMET131
HPHE232
HPHE236

site_idAD2
Number of Residues7
Detailsbinding site for Di-peptide EHL J 301 and MET J 131
ChainResidue
JTHR127
JALA130
JTYR132
JASP133
JLYS134
JGLY135
JPHE178

site_idAD3
Number of Residues7
Detailsbinding site for Di-peptide EHL L 301 and MET L 131
ChainResidue
KILE160
LTHR127
LALA130
LTYR132
LASP133
LLYS134
LPHE178

site_idAD4
Number of Residues7
Detailsbinding site for Di-peptide EHL L 301 and MET L 131
ChainResidue
KILE160
LTHR127
LALA130
LTYR132
LASP133
LLYS134
LPHE178

site_idAD5
Number of Residues5
Detailsbinding site for Di-peptide EHL L 301 and TYR L 128
ChainResidue
LTHR127
LALA129
LALA130
LPHE232
LPHE236

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsBINDING: BINDING => ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11735396
ChainResidueDetails
AHIS11
BGLN66
BLEU103
BTHR147
BTYR155
BARG200
CHIS11
CPHE17
CGLN66
CLEU103
CTHR147
APHE17
CTYR155
CARG200
DHIS11
DPHE17
DGLN66
DLEU103
DTHR147
DTYR155
DARG200
EHIS11
AGLN66
EPHE17
EGLN66
ELEU103
ETHR147
ETYR155
EARG200
FHIS11
FPHE17
FGLN66
FLEU103
ALEU103
FTHR147
FTYR155
FARG200
GHIS11
GPHE17
GGLN66
GLEU103
GTHR147
GTYR155
GARG200
ATHR147
HHIS11
HPHE17
HGLN66
HLEU103
HTHR147
HTYR155
HARG200
IHIS11
IPHE17
IGLN66
ATYR155
ILEU103
ITHR147
ITYR155
IARG200
JHIS11
JPHE17
JGLN66
JLEU103
JTHR147
JTYR155
AARG200
JARG200
KHIS11
KPHE17
KGLN66
KLEU103
KTHR147
KTYR155
KARG200
LHIS11
LPHE17
BHIS11
LGLN66
LLEU103
LTHR147
LTYR155
LARG200
BPHE17

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING:
ChainResidueDetails
AALA125
JALA125
KALA125
LALA125
BALA125
CALA125
DALA125
EALA125
FALA125
GALA125
HALA125
IALA125

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER81
JSER81
KSER81
LSER81
BSER81
CSER81
DSER81
ESER81
FSER81
GSER81
HSER81
ISER81

site_idSWS_FT_FI4
Number of Residues36
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS249
DLYS249
DLYS250
ELYS249
ELYS250
FLYS249
FLYS250
GLYS249
GLYS250
HLYS249
HLYS250
ILYS249
ILYS250
JLYS249
ALYS250
JLYS250
KLYS249
KLYS250
LLYS249
LLYS250
BLYS249
BLYS250
CLYS249
CLYS250

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
AGLY149electrostatic stabiliser, hydrogen bond donor
ATYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
AHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA10
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
JGLY149electrostatic stabiliser, hydrogen bond donor
JTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
JHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA11
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
KGLY149electrostatic stabiliser, hydrogen bond donor
KTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
KHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA12
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
LGLY149electrostatic stabiliser, hydrogen bond donor
LTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
LHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA2
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
BGLY149electrostatic stabiliser, hydrogen bond donor
BTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
BHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA3
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
CGLY149electrostatic stabiliser, hydrogen bond donor
CTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
CHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA4
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
DGLY149electrostatic stabiliser, hydrogen bond donor
DTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
DHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA5
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
EGLY149electrostatic stabiliser, hydrogen bond donor
ETYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
EHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA6
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
FGLY149electrostatic stabiliser, hydrogen bond donor
FTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
FHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA7
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
GGLY149electrostatic stabiliser, hydrogen bond donor
GTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
GHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA8
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
HGLY149electrostatic stabiliser, hydrogen bond donor
HTYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
HHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA9
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
IGLY149electrostatic stabiliser, hydrogen bond donor
ITYR155electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
IHIS161hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

223790

PDB entries from 2024-08-14

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