6LH4
Crystal structural of MacroD1-ADPr complex
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue AR6 A 601 |
| Chain | Residue |
| A | ASP160 |
| A | VAL183 |
| A | ASP184 |
| A | CYS186 |
| A | CYS266 |
| A | SER268 |
| A | THR269 |
| A | GLY270 |
| A | VAL271 |
| A | PHE272 |
| A | PHE306 |
| A | ILE161 |
| A | HOH717 |
| A | HOH722 |
| A | HOH738 |
| A | HOH748 |
| A | HOH752 |
| A | HOH757 |
| A | HOH777 |
| B | PRO142 |
| B | ARG143 |
| A | ALA172 |
| A | ALA173 |
| A | ASN174 |
| A | GLY179 |
| A | GLY180 |
| A | GLY181 |
| A | GLY182 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | binding site for residue AR6 B 601 |
| Chain | Residue |
| B | SER159 |
| B | ASP160 |
| B | ILE161 |
| B | ALA172 |
| B | ALA173 |
| B | ASN174 |
| B | GLY179 |
| B | GLY180 |
| B | GLY181 |
| B | GLY182 |
| B | VAL183 |
| B | ASP184 |
| B | CYS186 |
| B | CYS266 |
| B | SER268 |
| B | THR269 |
| B | GLY270 |
| B | VAL271 |
| B | PHE272 |
| B | PHE306 |
| B | LEU307 |
| B | HOH712 |
| B | HOH729 |
| B | HOH733 |
| B | HOH745 |
| B | HOH768 |
| B | HOH772 |
| B | HOH781 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | binding site for residue AR6 C 601 |
| Chain | Residue |
| C | ASP160 |
| C | ILE161 |
| C | ALA172 |
| C | ALA173 |
| C | ASN174 |
| C | GLY179 |
| C | GLY180 |
| C | GLY181 |
| C | GLY182 |
| C | VAL183 |
| C | ASP184 |
| C | CYS186 |
| C | CYS266 |
| C | SER268 |
| C | THR269 |
| C | GLY270 |
| C | VAL271 |
| C | PHE272 |
| C | PHE306 |
| C | LEU307 |
| C | HOH716 |
| C | HOH717 |
| C | HOH726 |
| C | HOH742 |
| C | HOH747 |
| C | HOH754 |
| C | HOH766 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide AR6 D 601 and THR D 269 |
| Chain | Residue |
| D | PHE272 |
| D | PHE306 |
| D | LEU307 |
| D | ASP310 |
| D | HOH704 |
| D | HOH714 |
| D | ASP160 |
| D | ILE161 |
| D | ALA172 |
| D | ALA173 |
| D | GLY179 |
| D | GLY180 |
| D | GLY181 |
| D | GLY182 |
| D | VAL183 |
| D | ASP184 |
| D | CYS186 |
| D | CYS266 |
| D | ILE267 |
| D | SER268 |
| D | GLY270 |
| D | VAL271 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:A1Z1Q3 |
| Chain | Residue | Details |
| A | SER159 | |
| B | PHE306 | |
| C | SER159 | |
| C | ALA172 | |
| C | GLY179 | |
| C | ILE267 | |
| C | PHE306 | |
| D | SER159 | |
| D | ALA172 | |
| D | GLY179 | |
| D | ILE267 | |
| A | ALA172 | |
| D | PHE306 | |
| A | GLY179 | |
| A | ILE267 | |
| A | PHE306 | |
| B | SER159 | |
| B | ALA172 | |
| B | GLY179 | |
| B | ILE267 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Breakpoint for translocation to form RUNX1-MACROD1 => ECO:0000269|PubMed:17532767 |
| Chain | Residue | Details |
| A | SER100 | |
| B | SER100 | |
| C | SER100 | |
| D | SER100 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q922B1 |
| Chain | Residue | Details |
| A | LYS96 | |
| D | LYS96 | |
| D | LYS103 | |
| D | LYS129 | |
| A | LYS103 | |
| A | LYS129 | |
| B | LYS96 | |
| B | LYS103 | |
| B | LYS129 | |
| C | LYS96 | |
| C | LYS103 | |
| C | LYS129 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q922B1 |
| Chain | Residue | Details |
| A | LYS163 | |
| B | LYS163 | |
| C | LYS163 | |
| D | LYS163 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS138 | |
| B | LYS138 | |
| C | LYS138 | |
| D | LYS138 |
