6LC1
Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0043565 | molecular_function | sequence-specific DNA binding |
| J | 0003700 | molecular_function | DNA-binding transcription factor activity |
| J | 0006355 | biological_process | regulation of DNA-templated transcription |
| J | 0008270 | molecular_function | zinc ion binding |
| J | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN J 401 |
| Chain | Residue |
| J | CYS303 |
| J | CYS309 |
| J | CYS319 |
| J | CYS322 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN J 402 |
| Chain | Residue |
| J | CYS267 |
| J | CYS270 |
| J | CYS284 |
| J | CYS287 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS270 |
| A | CYS284 |
| A | CYS287 |
| A | CYS267 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | CYS303 |
| A | CYS309 |
| A | CYS319 |
| A | CYS322 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 401 |
| Chain | Residue |
| D | CYS267 |
| D | CYS270 |
| D | CYS284 |
| D | CYS287 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 402 |
| Chain | Residue |
| D | CYS303 |
| D | CYS309 |
| D | CYS319 |
| D | CYS322 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 401 |
| Chain | Residue |
| G | CYS267 |
| G | CYS270 |
| G | CYS284 |
| G | CYS287 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 402 |
| Chain | Residue |
| G | CYS303 |
| G | CYS309 |
| G | CYS319 |
| G | CYS322 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CavCg.Dnascq.HYgvrtCegCkgFFkR |
| Chain | Residue | Details |
| J | CYS267-ARG293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 176 |
| Details | Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P22829","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17360704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
