Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6L47

Structure of the human sterol O-acyltransferase 1 in complex with CI-976

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008374	molecular_function	O-acyltransferase activity
A	0016020	cellular_component	membrane
A	0034736	molecular_function	cholesterol O-acyltransferase activity
A	0042632	biological_process	cholesterol homeostasis
B	0008374	molecular_function	O-acyltransferase activity
B	0016020	cellular_component	membrane
B	0034736	molecular_function	cholesterol O-acyltransferase activity
B	0042632	biological_process	cholesterol homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue E5L A 1001

Chain	Residue
A	TYR416
A	TYR417
A	TRP420
A	ASN421
A	VAL424
A	HIS460
A	ASN511

site_id	AC2
Number of Residues	13
Details	binding site for residue CLR A 1002

Chain	Residue
A	PHE145
A	ILE146
A	CYS333
A	TYR336
A	PHE378
A	LEU379
A	PHE382
A	TRP408
B	HIS137
B	THR140
B	ILE141
A	ILE138
A	TYR142

site_id	AC3
Number of Residues	7
Details	binding site for residue E5L B 1001

Chain	Residue
B	TYR416
B	TYR417
B	TRP420
B	ASN421
B	VAL424
B	HIS460
B	ASN511

site_id	AC4
Number of Residues	13
Details	binding site for residue CLR B 1002

Chain	Residue
A	HIS137
A	THR140
A	ILE141
B	ILE138
B	TYR142
B	PHE145
B	ILE146
B	CYS333
B	TYR336
B	PHE378
B	LEU379
B	PHE382
B	TRP408

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	94
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	200
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Motif: {"description":"FYXDWWN motif","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"16154994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16647063","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)