6L2I
IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_WT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0009099 | biological_process | valine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0009099 | biological_process | valine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | THR268 |
| A | GLU269 |
| A | HOH524 |
| A | HOH577 |
| B | ALA209 |
| B | GLU212 |
| B | HOH549 |
| B | HOH611 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | GLU84 |
| A | ILE85 |
| A | GLN86 |
| A | GLN87 |
| A | ASN111 |
| A | PHE116 |
| A | VAL292 |
| A | HOH571 |
| A | ASP83 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ALA310 |
| A | GLU315 |
| A | LYS316 |
| A | ALA319 |
| A | HOH555 |
| A | HOH567 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | ARG299 |
| A | ARG306 |
| A | HOH528 |
| B | ASN253 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | LYS12 |
| A | HOH509 |
| A | HOH544 |
| A | HOH563 |
| B | ASP17 |
| B | GLY18 |
| B | GLY41 |
| B | ARG42 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | ARG49 |
| A | PRO50 |
| A | GLY51 |
| A | LYS52 |
| A | SER53 |
| A | HOH503 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | GLU8 |
| A | SER40 |
| A | LYS170 |
| A | ARG176 |
| A | HOH501 |
| A | HOH502 |
| A | HOH543 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | GLN270 |
| A | ASN274 |
| A | HOH519 |
| A | HOH525 |
| A | HOH580 |
| B | THR268 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 409 |
| Chain | Residue |
| A | THR268 |
| A | HOH515 |
| A | HOH530 |
| A | HOH580 |
| A | HOH687 |
| B | GLN270 |
| B | ASN274 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| A | GLU227 |
| A | HOH506 |
| B | ASP191 |
| B | GLU195 |
| B | SO4412 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| B | ASP191 |
| B | GLU195 |
| B | HOH514 |
| B | HOH593 |
| B | HOH618 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| A | LYS9 |
| B | GLU8 |
| B | SER40 |
| B | LYS170 |
| B | ARG176 |
| B | HOH523 |
| B | HOH598 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| A | ALA209 |
| A | GLU212 |
| A | HOH560 |
| B | THR268 |
| B | GLU269 |
| B | HOH526 |
| B | HOH558 |
| B | HOH669 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| A | GLU208 |
| A | LEU312 |
| B | ARG248 |
| B | HOH544 |
| B | HOH553 |
| B | HOH558 |
| B | HOH578 |
| B | HOH616 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 407 |
| Chain | Residue |
| B | HOH545 |
| B | HOH610 |
| B | HOH611 |
| A | ARG248 |
| B | GLU208 |
| B | LEU312 |
| B | HOH525 |
| B | HOH534 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 408 |
| Chain | Residue |
| B | LYS72 |
| B | LEU73 |
| B | ALA74 |
| B | ASP75 |
| B | GLU99 |
| B | ASN102 |
| B | HOH678 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 409 |
| Chain | Residue |
| A | ASN253 |
| B | ARG299 |
| B | ARG306 |
| B | HOH513 |
| B | HOH547 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 410 |
| Chain | Residue |
| B | ARG49 |
| B | ARG299 |
| B | HOH725 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 411 |
| Chain | Residue |
| A | SER250 |
| B | SER28 |
| B | HIS31 |
| B | PRO133 |
| B | GLY134 |
| B | HIS135 |
| B | HOH522 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 412 |
| Chain | Residue |
| A | GLU231 |
| B | ASP191 |
| B | GLU195 |
| B | CYS200 |
| B | MG402 |
| B | HOH515 |
| B | HOH561 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00435 |
| Chain | Residue | Details |
| A | HIS108 | |
| B | HIS108 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00435 |
| Chain | Residue | Details |
| A | TYR26 | |
| A | SER252 | |
| B | TYR26 | |
| B | ARG49 | |
| B | SER53 | |
| B | ASP83 | |
| B | GLY134 | |
| B | ASP191 | |
| B | GLU195 | |
| B | GLU227 | |
| B | GLU231 | |
| A | ARG49 | |
| B | SER252 | |
| A | SER53 | |
| A | ASP83 | |
| A | GLY134 | |
| A | ASP191 | |
| A | GLU195 | |
| A | GLU227 | |
| A | GLU231 |
