6L0F

Crystal structure of dihydroorotase in complex with 5-Aminouracil from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004151	molecular_function	dihydroorotase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004151	molecular_function	dihydroorotase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004151	molecular_function	dihydroorotase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0004151	molecular_function	dihydroorotase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue WBU A 401

Chain	Residue
A	HIS16
A	HIS262
A	ALA275
A	ZN402
A	ZN403
A	ARG18
A	ASN43
A	KCX98
A	THR105
A	THR106
A	HIS137
A	ASP258
A	ALA260

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 402

Chain	Residue
A	HIS14
A	HIS16
A	KCX98
A	ASP258
A	WBU401

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN A 403

Chain	Residue
A	KCX98
A	HIS137
A	HIS180
A	LYS230
A	WBU401

---

site_id	AC4
Number of Residues	12
Details	binding site for residue WBU B 401

Chain	Residue
B	HIS16
B	ARG18
B	ASN43
B	KCX98
B	THR105
B	THR106
B	ASP258
B	ALA260
B	HIS262
B	ALA275
B	ZN402
B	ZN403

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN B 402

Chain	Residue
B	HIS14
B	HIS16
B	KCX98
B	ASP258
B	WBU401

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 403

Chain	Residue
B	KCX98
B	HIS137
B	HIS180
B	WBU401

---

site_id	AC7
Number of Residues	13
Details	binding site for residue WBU C 401

Chain	Residue
C	HIS16
C	ARG18
C	ASN43
C	KCX98
C	THR105
C	THR106
C	LYS230
C	ASP258
C	ALA260
C	HIS262
C	ALA275
C	ZN402
C	ZN403

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN C 402

Chain	Residue
C	HIS14
C	HIS16
C	KCX98
C	ASP258
C	WBU401

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 403

Chain	Residue
C	KCX98
C	HIS137
C	HIS180
C	WBU401

---

site_id	AD1
Number of Residues	11
Details	binding site for residue WBU D 401

Chain	Residue
D	HIS16
D	ARG18
D	ASN43
D	KCX98
D	THR105
D	THR106
D	ASP258
D	HIS262
D	ALA275
D	ZN402
D	ZN403

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN D 402

Chain	Residue
D	KCX98
D	HIS137
D	HIS180
D	WBU401

---

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN D 403

Chain	Residue
D	HIS14
D	HIS16
D	KCX98
D	ASP258
D	WBU401

---

Functional Information from PROSITE/UniProt

site_id	PS00482
Number of Residues	9
Details	DIHYDROOROTASE_1 Dihydroorotase signature 1. DMHVHVReG

Chain	Residue	Details
A	ASP12-GLY20

---

site_id	PS00483
Number of Residues	12
Details	DIHYDROOROTASE_2 Dihydroorotase signature 2. GSDsAPHpvqnK

Chain	Residue	Details
A	GLY256-LYS267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P05020","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"UniProtKB","id":"P05020","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"UniProtKB","id":"P05020","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---