6KYL

Crystal Structure of Phosphatidic acid Transporter Ups1/Mdm35 in Complex with (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate

Replaces:  5JQO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006869	biological_process	lipid transport
A	0007005	biological_process	mitochondrion organization
A	0015914	biological_process	phospholipid transport
A	0033108	biological_process	mitochondrial respiratory chain complex assembly
A	0045332	biological_process	phospholipid translocation
A	0120009	biological_process	intermembrane lipid transfer
A	1990050	molecular_function	phosphatidic acid transfer activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0015914	biological_process	phospholipid transport
B	0016020	cellular_component	membrane
B	0032048	biological_process	cardiolipin metabolic process
B	0045332	biological_process	phospholipid translocation
B	0120009	biological_process	intermembrane lipid transfer
B	1990050	molecular_function	phosphatidic acid transfer activity
B	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0006869	biological_process	lipid transport
C	0007005	biological_process	mitochondrion organization
C	0015914	biological_process	phospholipid transport
C	0033108	biological_process	mitochondrial respiratory chain complex assembly
C	0045332	biological_process	phospholipid translocation
C	0120009	biological_process	intermembrane lipid transfer
C	1990050	molecular_function	phosphatidic acid transfer activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0015914	biological_process	phospholipid transport
D	0016020	cellular_component	membrane
D	0032048	biological_process	cardiolipin metabolic process
D	0045332	biological_process	phospholipid translocation
D	0120009	biological_process	intermembrane lipid transfer
D	1990050	molecular_function	phosphatidic acid transfer activity
D	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 44E B 201

Chain	Residue
B	HIS33
B	LYS58
B	SER59
B	THR76
B	ILE78
B	ASN97
B	MET104
D	ASN152

---

site_id	AC2
Number of Residues	9
Details	binding site for residue 44E D 201

Chain	Residue
D	HIS33
D	LYS58
D	GLY60
D	THR74
D	THR76
D	ILE78
D	ASN97
D	MET104
B	ASN152

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26235513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26071601","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26071601","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26235513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---