6KYE

The crystal structure of recombinant human adult hemoglobin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0006954	biological_process	inflammatory response
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046872	molecular_function	metal ion binding
A	0048821	biological_process	erythrocyte development
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0006954	biological_process	inflammatory response
B	0008217	biological_process	regulation of blood pressure
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030185	biological_process	nitric oxide transport
B	0030492	molecular_function	hemoglobin binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0048821	biological_process	erythrocyte development
B	0070062	cellular_component	extracellular exosome
B	0070293	biological_process	renal absorption
B	0070527	biological_process	platelet aggregation
B	0071682	cellular_component	endocytic vesicle lumen
B	0072562	cellular_component	blood microparticle
B	0097746	biological_process	blood vessel diameter maintenance
B	0098869	biological_process	cellular oxidant detoxification
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0006954	biological_process	inflammatory response
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0046872	molecular_function	metal ion binding
C	0048821	biological_process	erythrocyte development
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0005833	cellular_component	hemoglobin complex
D	0006954	biological_process	inflammatory response
D	0008217	biological_process	regulation of blood pressure
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030185	biological_process	nitric oxide transport
D	0030492	molecular_function	hemoglobin binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0048821	biological_process	erythrocyte development
D	0070062	cellular_component	extracellular exosome
D	0070293	biological_process	renal absorption
D	0070527	biological_process	platelet aggregation
D	0071682	cellular_component	endocytic vesicle lumen
D	0072562	cellular_component	blood microparticle
D	0097746	biological_process	blood vessel diameter maintenance
D	0098869	biological_process	cellular oxidant detoxification
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005829	cellular_component	cytosol
E	0005833	cellular_component	hemoglobin complex
E	0006954	biological_process	inflammatory response
E	0015670	biological_process	carbon dioxide transport
E	0015671	biological_process	oxygen transport
E	0016020	cellular_component	membrane
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0030185	biological_process	nitric oxide transport
E	0031720	molecular_function	haptoglobin binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042542	biological_process	response to hydrogen peroxide
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0046872	molecular_function	metal ion binding
E	0048821	biological_process	erythrocyte development
E	0070062	cellular_component	extracellular exosome
E	0071682	cellular_component	endocytic vesicle lumen
E	0072562	cellular_component	blood microparticle
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005829	cellular_component	cytosol
F	0005833	cellular_component	hemoglobin complex
F	0006954	biological_process	inflammatory response
F	0008217	biological_process	regulation of blood pressure
F	0015670	biological_process	carbon dioxide transport
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0030185	biological_process	nitric oxide transport
F	0030492	molecular_function	hemoglobin binding
F	0031720	molecular_function	haptoglobin binding
F	0031721	molecular_function	hemoglobin alpha binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042542	biological_process	response to hydrogen peroxide
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0048821	biological_process	erythrocyte development
F	0070062	cellular_component	extracellular exosome
F	0070293	biological_process	renal absorption
F	0070527	biological_process	platelet aggregation
F	0071682	cellular_component	endocytic vesicle lumen
F	0072562	cellular_component	blood microparticle
F	0097746	biological_process	blood vessel diameter maintenance
F	0098869	biological_process	cellular oxidant detoxification
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005829	cellular_component	cytosol
G	0005833	cellular_component	hemoglobin complex
G	0006954	biological_process	inflammatory response
G	0015670	biological_process	carbon dioxide transport
G	0015671	biological_process	oxygen transport
G	0016020	cellular_component	membrane
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0030185	biological_process	nitric oxide transport
G	0031720	molecular_function	haptoglobin binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042542	biological_process	response to hydrogen peroxide
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0046872	molecular_function	metal ion binding
G	0048821	biological_process	erythrocyte development
G	0070062	cellular_component	extracellular exosome
G	0071682	cellular_component	endocytic vesicle lumen
G	0072562	cellular_component	blood microparticle
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005829	cellular_component	cytosol
H	0005833	cellular_component	hemoglobin complex
H	0006954	biological_process	inflammatory response
H	0008217	biological_process	regulation of blood pressure
H	0015670	biological_process	carbon dioxide transport
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0030185	biological_process	nitric oxide transport
H	0030492	molecular_function	hemoglobin binding
H	0031720	molecular_function	haptoglobin binding
H	0031721	molecular_function	hemoglobin alpha binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042542	biological_process	response to hydrogen peroxide
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0048821	biological_process	erythrocyte development
H	0070062	cellular_component	extracellular exosome
H	0070293	biological_process	renal absorption
H	0070527	biological_process	platelet aggregation
H	0071682	cellular_component	endocytic vesicle lumen
H	0072562	cellular_component	blood microparticle
H	0097746	biological_process	blood vessel diameter maintenance
H	0098869	biological_process	cellular oxidant detoxification
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004601	molecular_function	peroxidase activity
I	0005344	molecular_function	oxygen carrier activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005829	cellular_component	cytosol
I	0005833	cellular_component	hemoglobin complex
I	0006954	biological_process	inflammatory response
I	0015670	biological_process	carbon dioxide transport
I	0015671	biological_process	oxygen transport
I	0016020	cellular_component	membrane
I	0019825	molecular_function	oxygen binding
I	0020037	molecular_function	heme binding
I	0030185	biological_process	nitric oxide transport
I	0031720	molecular_function	haptoglobin binding
I	0031838	cellular_component	haptoglobin-hemoglobin complex
I	0042542	biological_process	response to hydrogen peroxide
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0046872	molecular_function	metal ion binding
I	0048821	biological_process	erythrocyte development
I	0070062	cellular_component	extracellular exosome
I	0071682	cellular_component	endocytic vesicle lumen
I	0072562	cellular_component	blood microparticle
I	0098869	biological_process	cellular oxidant detoxification
J	0004601	molecular_function	peroxidase activity
J	0005344	molecular_function	oxygen carrier activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005829	cellular_component	cytosol
J	0005833	cellular_component	hemoglobin complex
J	0006954	biological_process	inflammatory response
J	0008217	biological_process	regulation of blood pressure
J	0015670	biological_process	carbon dioxide transport
J	0015671	biological_process	oxygen transport
J	0019825	molecular_function	oxygen binding
J	0020037	molecular_function	heme binding
J	0030185	biological_process	nitric oxide transport
J	0030492	molecular_function	hemoglobin binding
J	0031720	molecular_function	haptoglobin binding
J	0031721	molecular_function	hemoglobin alpha binding
J	0031838	cellular_component	haptoglobin-hemoglobin complex
J	0042542	biological_process	response to hydrogen peroxide
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
J	0046872	molecular_function	metal ion binding
J	0048821	biological_process	erythrocyte development
J	0070062	cellular_component	extracellular exosome
J	0070293	biological_process	renal absorption
J	0070527	biological_process	platelet aggregation
J	0071682	cellular_component	endocytic vesicle lumen
J	0072562	cellular_component	blood microparticle
J	0097746	biological_process	blood vessel diameter maintenance
J	0098869	biological_process	cellular oxidant detoxification
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004601	molecular_function	peroxidase activity
K	0005344	molecular_function	oxygen carrier activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005829	cellular_component	cytosol
K	0005833	cellular_component	hemoglobin complex
K	0006954	biological_process	inflammatory response
K	0015670	biological_process	carbon dioxide transport
K	0015671	biological_process	oxygen transport
K	0016020	cellular_component	membrane
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0030185	biological_process	nitric oxide transport
K	0031720	molecular_function	haptoglobin binding
K	0031838	cellular_component	haptoglobin-hemoglobin complex
K	0042542	biological_process	response to hydrogen peroxide
K	0042744	biological_process	hydrogen peroxide catabolic process
K	0046872	molecular_function	metal ion binding
K	0048821	biological_process	erythrocyte development
K	0070062	cellular_component	extracellular exosome
K	0071682	cellular_component	endocytic vesicle lumen
K	0072562	cellular_component	blood microparticle
K	0098869	biological_process	cellular oxidant detoxification
L	0004601	molecular_function	peroxidase activity
L	0005344	molecular_function	oxygen carrier activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005829	cellular_component	cytosol
L	0005833	cellular_component	hemoglobin complex
L	0006954	biological_process	inflammatory response
L	0008217	biological_process	regulation of blood pressure
L	0015670	biological_process	carbon dioxide transport
L	0015671	biological_process	oxygen transport
L	0019825	molecular_function	oxygen binding
L	0020037	molecular_function	heme binding
L	0030185	biological_process	nitric oxide transport
L	0030492	molecular_function	hemoglobin binding
L	0031720	molecular_function	haptoglobin binding
L	0031721	molecular_function	hemoglobin alpha binding
L	0031838	cellular_component	haptoglobin-hemoglobin complex
L	0042542	biological_process	response to hydrogen peroxide
L	0042744	biological_process	hydrogen peroxide catabolic process
L	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
L	0046872	molecular_function	metal ion binding
L	0048821	biological_process	erythrocyte development
L	0070062	cellular_component	extracellular exosome
L	0070293	biological_process	renal absorption
L	0070527	biological_process	platelet aggregation
L	0071682	cellular_component	endocytic vesicle lumen
L	0072562	cellular_component	blood microparticle
L	0097746	biological_process	blood vessel diameter maintenance
L	0098869	biological_process	cellular oxidant detoxification
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue HEM A 201

Chain	Residue
A	TYR42
A	PHE98
A	LEU101
A	LEU136
A	CMO202
A	HOH305
A	PHE43
A	HIS58
A	LYS61
A	ALA65
A	LEU86
A	HIS87
A	LEU91
A	ASN97

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CMO A 202

Chain	Residue
A	HIS58
A	VAL62
A	HEM201

---

site_id	AC3
Number of Residues	16
Details	binding site for residue HEM B 201

Chain	Residue
B	THR38
B	PHE41
B	PHE42
B	PHE45
B	HIS63
B	LYS66
B	ALA70
B	PHE71
B	LEU88
B	HIS92
B	LEU96
B	ASN102
B	LEU106
B	VAL137
B	LEU141
B	CMO202

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CMO B 202

Chain	Residue
B	HIS63
B	VAL67
B	HEM201

---

site_id	AC5
Number of Residues	16
Details	binding site for residue HEM C 201

Chain	Residue
C	TYR42
C	PHE43
C	HIS45
C	PHE46
C	HIS58
C	LYS61
C	LEU83
C	HIS87
C	LEU91
C	VAL93
C	ASN97
C	PHE98
C	LEU101
C	VAL132
C	LEU136
C	CMO202

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CMO C 202

Chain	Residue
C	HIS58
C	VAL62
C	HEM201

---

site_id	AC7
Number of Residues	14
Details	binding site for residue HEM D 201

Chain	Residue
D	PHE41
D	PHE42
D	HIS63
D	LYS66
D	PHE71
D	HIS92
D	LEU96
D	VAL98
D	ASN102
D	LEU106
D	VAL137
D	LEU141
D	CMO202
D	HOH301

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CMO D 202

Chain	Residue
D	HIS63
D	VAL67
D	HEM201

---

site_id	AC9
Number of Residues	17
Details	binding site for residue HEM E 201

Chain	Residue
E	TYR42
E	PHE43
E	PHE46
E	HIS58
E	LYS61
E	ALA65
E	LEU83
E	HIS87
E	LEU91
E	VAL93
E	ASN97
E	PHE98
E	LEU101
E	VAL132
E	LEU136
E	CMO202
E	HOH304

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CMO E 202

Chain	Residue
E	LEU29
E	HIS58
E	VAL62
E	HEM201

---

site_id	AD2
Number of Residues	15
Details	binding site for residue HEM F 201

Chain	Residue
F	LEU88
F	HIS92
F	LEU96
F	VAL98
F	ASN102
F	LEU106
F	VAL137
F	LEU141
F	CMO202
A	HIS45
F	PHE41
F	PHE42
F	HIS63
F	LYS66
F	PHE71

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CMO F 202

Chain	Residue
F	LEU28
F	HIS63
F	VAL67
F	HEM201

---

site_id	AD4
Number of Residues	15
Details	binding site for residue HEM G 201

Chain	Residue
G	THR39
G	TYR42
G	PHE43
G	PHE46
G	HIS58
G	LYS61
G	LEU83
G	HIS87
G	LEU91
G	ASN97
G	PHE98
G	LEU101
G	VAL132
G	LEU136
G	CMO202

---

site_id	AD5
Number of Residues	3
Details	binding site for residue CMO G 202

Chain	Residue
G	HIS58
G	VAL62
G	HEM201

---

site_id	AD6
Number of Residues	12
Details	binding site for residue HEM H 201

Chain	Residue
H	PHE41
H	PHE42
H	HIS63
H	PHE71
H	LEU88
H	HIS92
H	LEU96
H	ASN102
H	LEU106
H	VAL137
H	LEU141
H	CMO202

---

site_id	AD7
Number of Residues	3
Details	binding site for residue CMO H 202

Chain	Residue
H	HIS63
H	VAL67
H	HEM201

---

site_id	AD8
Number of Residues	14
Details	binding site for residue HEM I 201

Chain	Residue
I	TYR42
I	PHE43
I	HIS45
I	HIS58
I	LYS61
I	LEU83
I	HIS87
I	LEU91
I	ASN97
I	PHE98
I	LEU101
I	VAL132
I	LEU136
I	CMO202

---

site_id	AD9
Number of Residues	3
Details	binding site for residue CMO I 202

Chain	Residue
I	HIS58
I	VAL62
I	HEM201

---

site_id	AE1
Number of Residues	13
Details	binding site for residue HEM J 201

Chain	Residue
J	PHE41
J	PHE42
J	PHE45
J	HIS63
J	PHE71
J	LEU91
J	HIS92
J	LEU96
J	ASN102
J	LEU106
J	VAL137
J	LEU141
J	CMO202

---

site_id	AE2
Number of Residues	3
Details	binding site for residue CMO J 202

Chain	Residue
J	HIS63
J	VAL67
J	HEM201

---

site_id	AE3
Number of Residues	16
Details	binding site for residue HEM K 201

Chain	Residue
K	TYR42
K	PHE43
K	PHE46
K	HIS58
K	LYS61
K	LEU83
K	LEU86
K	HIS87
K	LEU91
K	VAL93
K	ASN97
K	PHE98
K	LEU101
K	VAL132
K	LEU136
K	CMO202

---

site_id	AE4
Number of Residues	4
Details	binding site for residue CMO K 202

Chain	Residue
K	LEU29
K	HIS58
K	VAL62
K	HEM201

---

site_id	AE5
Number of Residues	15
Details	binding site for residue HEM L 201

Chain	Residue
L	PHE41
L	PHE42
L	HIS63
L	LYS66
L	VAL67
L	PHE71
L	LEU88
L	HIS92
L	LEU96
L	VAL98
L	ASN102
L	PHE103
L	LEU106
L	CMO202
L	HOH305

---

site_id	AE6
Number of Residues	5
Details	binding site for residue CMO L 202

Chain	Residue
L	LEU28
L	PHE42
L	HIS63
L	VAL67
L	HEM201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Peptide: {"description":"Hemopressin","featureId":"PRO_0000455882","evidences":[{"source":"PubMed","id":"18077343","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	198
Details	Site: {"description":"(Microbial infection) Cleavage; by N.americanus apr-2","evidences":[{"source":"PubMed","id":"12552433","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	30
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	18
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; alternate","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	30
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1004
Details	Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	54
Details	Peptide: {"description":"LVV-hemorphin-7","featureId":"PRO_0000296641"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	36
Details	Peptide: {"description":"Spinorphin","featureId":"PRO_0000424226"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	23
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	6
Details	Binding site: {"description":"distal binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Binding site: {"description":"proximal binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	5
Details	Modified residue: {"description":"N-pyruvate 2-iminyl-valine; in Hb A1b"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	6
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"8637569","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9843411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) valine; in Hb A1c","evidences":[{"source":"PubMed","id":"635569","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---