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6KXX

Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound A)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue T02 A 501
ChainResidue
AILE272
ALEU456
ATYR464
APHE273
ACYS276
ASER280
ATYR314
ALEU347
AILE354
AMET355
AHIS440

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O70343
ChainResidueDetails
BLYS146
ATYR314
ATYR464

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Essential for heterodimerization with RXRA
ChainResidueDetails
ALEU433

226707

PDB entries from 2024-10-30

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