6KR6
Crystal structure of Drosophila Piwi
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0000791 | cellular_component | euchromatin |
| A | 0000792 | cellular_component | heterochromatin |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007279 | biological_process | pole cell formation |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0007294 | biological_process | germarium-derived oocyte fate determination |
| A | 0009994 | biological_process | oocyte differentiation |
| A | 0010369 | cellular_component | chromocenter |
| A | 0010526 | biological_process | transposable element silencing |
| A | 0016441 | biological_process | post-transcriptional gene silencing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030718 | biological_process | germ-line stem cell population maintenance |
| A | 0031047 | biological_process | regulatory ncRNA-mediated gene silencing |
| A | 0031490 | molecular_function | chromatin DNA binding |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034584 | molecular_function | piRNA binding |
| A | 0034587 | biological_process | piRNA processing |
| A | 0043073 | cellular_component | germ cell nucleus |
| A | 0043186 | cellular_component | P granule |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048132 | biological_process | female germ-line stem cell asymmetric division |
| A | 0048133 | biological_process | male germ-line stem cell asymmetric division |
| A | 0048477 | biological_process | oogenesis |
| A | 0070725 | cellular_component | Yb body |
| A | 0140990 | biological_process | primary piRNA processing |
| A | 0140991 | biological_process | piRNA-mediated gene silencing by mRNA destabilization |
| A | 0141005 | biological_process | transposable element silencing by heterochromatin formation |
| A | 0141006 | biological_process | transposable element silencing by piRNA-mediated heterochromatin formation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | GLN589 |
| A | LEU843 |
| B | U1 |
| B | A2 |
| B | U3 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 902 |
| Chain | Residue |
| A | HIS244 |
| A | ASP749 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 903 |
| Chain | Residue |
| A | ASN827 |
| A | HIS829 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue HG A 904 |
| Chain | Residue |
| A | CYS317 |
| A | ARG320 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue HG A 905 |
| Chain | Residue |
| A | ASP685 |
| A | CYS814 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue HG A 906 |
| Chain | Residue |
| A | ALA479 |
| A | GLN512 |
| A | CYS531 |
| A | SER534 |
| A | PRO536 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue HG A 907 |
| Chain | Residue |
| A | CYS648 |
| A | THR657 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue HG A 908 |
| Chain | Residue |
| A | CYS188 |
| A | GLN243 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue HG A 909 |
| Chain | Residue |
| A | CYS271 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 910 |
| Chain | Residue |
| A | HIS116 |
| A | HIS118 |
| A | GLN152 |
| A | ASP535 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue ZN A 911 |
| Chain | Residue |
| A | HIS446 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 912 |
| Chain | Residue |
| A | ASP614 |
| A | ASP685 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 913 |
| Chain | Residue |
| A | ASP473 |
| A | ASP476 |
| A | LYS537 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 914 |
| Chain | Residue |
| A | GLU414 |
| A | HIS488 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"A8D8P8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"A8D8P8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
