6KR3
Crystal structure of Dengue virus nonstructural protein NS5 (form 2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | methyltransferase cap1 activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 1004 |
| Chain | Residue |
| B | ARG326 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 1006 |
| Chain | Residue |
| A | VAL723 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 1007 |
| Chain | Residue |
| A | LEU571 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue IOD A 1009 |
| Chain | Residue |
| A | ASN777 |
| A | PRO884 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 1011 |
| Chain | Residue |
| A | SER189 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 1012 |
| Chain | Residue |
| A | ARG737 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue SAH A 1013 |
| Chain | Residue |
| A | GLY81 |
| A | CYS82 |
| A | GLY83 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| A | HIS110 |
| A | GLU111 |
| A | VAL130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | SER56 |
| A | GLY58 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SAH A 1014 |
| Chain | Residue |
| A | ARG68 |
| A | LEU70 |
| A | ASN223 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1015 |
| Chain | Residue |
| A | GLU438 |
| A | HIS442 |
| A | CYS447 |
| A | CYS450 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1016 |
| Chain | Residue |
| A | HIS712 |
| A | HIS714 |
| A | CYS728 |
| A | CYS847 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1017 |
| Chain | Residue |
| A | LYS12 |
| A | ARG16 |
| A | ARG237 |
| A | ILE240 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 1018 |
| Chain | Residue |
| A | PRO115 |
| A | VAL124 |
| A | LEU126 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue IOD B 1003 |
| Chain | Residue |
| B | ASP663 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SAH B 1004 |
| Chain | Residue |
| B | ARG68 |
| B | LEU70 |
| B | HOH1109 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for residue SAH B 1005 |
| Chain | Residue |
| B | SER56 |
| B | GLY81 |
| B | CYS82 |
| B | GLY86 |
| B | TRP87 |
| B | THR104 |
| B | LYS105 |
| B | HIS110 |
| B | VAL130 |
| B | ASP131 |
| B | VAL132 |
| B | PHE133 |
| B | ASP146 |
| B | ILE147 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1006 |
| Chain | Residue |
| B | GLU438 |
| B | HIS442 |
| B | CYS447 |
| B | CYS450 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1007 |
| Chain | Residue |
| B | HIS712 |
| B | HIS714 |
| B | CYS728 |
| B | CYS847 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 1008 |
| Chain | Residue |
| A | ASP333 |
| A | ILE334 |
| A | PRO336 |
| A | THR339 |
| B | ASP333 |
| B | ILE334 |
| B | PRO336 |
| B | THR339 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 1009 |
| Chain | Residue |
| A | LYS330 |
| A | PRO331 |
| A | TRP859 |
| B | MET343 |
| B | HOH1102 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 1010 |
| Chain | Residue |
| B | LYS330 |
| B | SER855 |
| B | TRP859 |
