6KR2
Crystal structure of Dengue virus nonstructural protein NS5 (form 1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 2001 |
| Chain | Residue |
| A | HIS712 |
| A | HIS714 |
| A | CYS728 |
| A | CYS847 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 2002 |
| Chain | Residue |
| A | GLU438 |
| A | HIS442 |
| A | CYS447 |
| A | CYS450 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue SAH A 2003 |
| Chain | Residue |
| A | GLY81 |
| A | CYS82 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| A | HIS110 |
| A | GLU111 |
| A | VAL130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | SER56 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1001 |
| Chain | Residue |
| B | GLU438 |
| B | HIS442 |
| B | CYS447 |
| B | CYS450 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1002 |
| Chain | Residue |
| B | HIS712 |
| B | HIS714 |
| B | CYS728 |
| B | CYS847 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue SAH B 1003 |
| Chain | Residue |
| B | SER56 |
| B | GLY81 |
| B | CYS82 |
| B | GLY83 |
| B | GLY86 |
| B | TRP87 |
| B | LYS105 |
| B | HIS110 |
| B | VAL130 |
| B | VAL132 |
| B | PHE133 |
| B | ASP146 |
