6KQI

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004949	molecular_function	cannabinoid receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 9GF A 1201

Chain	Residue
A	SER173
A	TRP356
A	MET363
A	PHE379
A	SER383
A	PHE174
A	PHE177
A	LYS192
A	LEU193
A	VAL196
A	ILE267
A	PHE268
A	TYR275

---

site_id	AC2
Number of Residues	7
Details	binding site for residue 9GL A 1202

Chain	Residue
A	HIS154
A	GLY157
A	SER158
A	CYS238
A	TRP241
A	THR242
A	ILE245

---

site_id	AC3
Number of Residues	6
Details	binding site for residue OLA A 1203

Chain	Residue
A	LEU374
A	VAL378
A	PHE381
A	CYS382
A	LEU385
A	OLC1207

---

site_id	AC4
Number of Residues	3
Details	binding site for residue OLA A 1204

Chain	Residue
A	TRP255
A	PHE278
A	OLC1207

---

site_id	AC5
Number of Residues	2
Details	binding site for residue OLA A 1205

Chain	Residue
A	LEU124
A	OLA1206

---

site_id	AC6
Number of Residues	3
Details	binding site for residue OLA A 1206

Chain	Residue
A	LEU124
A	THR125
A	OLA1205

---

site_id	AC7
Number of Residues	2
Details	binding site for residue OLC A 1207

Chain	Residue
A	OLA1203
A	OLA1204

---

site_id	AC8
Number of Residues	1
Details	binding site for residue PEG A 1210

Chain	Residue
A	PHE408

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"27768894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27851727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---