6KMJ

Crystal structure of Sth1 bromodomain in complex with H3K14Ac

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0016586	cellular_component	RSC-type complex
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GOL A 1401

Chain	Residue
A	ARG1285
C	LYS18
C	TYR22
A	ASP1286
A	VAL1293
A	ILE1294
A	GLU1295
A	GLU1327
A	ASN1328
A	HOH1509
A	HOH1521

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Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
C	ALY14-LEU20

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site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. TsiFeklpSkrdyp..DYFkvIekpMaidiIlknckngt..Yktleevrqalqt.MfeNArfY

Chain	Residue	Details
A	THR1275-TYR1332

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10911986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10975519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15719021","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-butyryllysine; alternate","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27105113","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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