6KLK
Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-FU
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004157 | molecular_function | dihydropyrimidinase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004157 | molecular_function | dihydropyrimidinase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| B | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue URF A 501 |
| Chain | Residue |
| A | HIS61 |
| A | ASN337 |
| A | ZN502 |
| A | ZN503 |
| A | LEU64 |
| A | KCX150 |
| A | PHE152 |
| A | TYR155 |
| A | MET288 |
| A | SER289 |
| A | ASP316 |
| A | CYS318 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | HIS59 |
| A | HIS61 |
| A | KCX150 |
| A | ASP316 |
| A | URF501 |
| A | ZN503 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 503 |
| Chain | Residue |
| A | KCX150 |
| A | HIS183 |
| A | HIS239 |
| A | URF501 |
| A | ZN502 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | HIS59 |
| B | HIS61 |
| B | KCX150 |
| B | ASP316 |
| B | ZN502 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | KCX150 |
| B | HIS183 |
| B | HIS239 |
| B | ZN501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9P903 |
| Chain | Residue | Details |
| A | HIS59 | |
| B | HIS61 | |
| B | TYR155 | |
| B | HIS183 | |
| B | HIS239 | |
| B | SER289 | |
| B | ASP316 | |
| B | ASN337 | |
| A | HIS61 | |
| A | TYR155 | |
| A | HIS183 | |
| A | HIS239 | |
| A | SER289 | |
| A | ASP316 | |
| A | ASN337 | |
| B | HIS59 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: via carbamate group => ECO:0000250|UniProtKB:Q9P903 |
| Chain | Residue | Details |
| A | KCX150 | |
| B | KCX150 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-carboxylysine => ECO:0000250|UniProtKB:Q9P903 |
| Chain | Residue | Details |
| A | KCX150 | |
| B | KCX150 |
