6KJ7
E. coli ATCase catalytic subunit mutant - G166P
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0070207 | biological_process | protein homotrimerization |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT |
| Chain | Residue | Details |
| A | PHE48-THR55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000269|PubMed:3380787 |
| Chain | Residue | Details |
| A | ARG54 | |
| A | THR55 | |
| A | ARG105 | |
| A | HIS134 | |
| A | GLN137 | |
| A | LEU267 | |
| A | PRO268 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787 |
| Chain | Residue | Details |
| A | LYS84 | |
| A | ARG167 | |
| A | ARG229 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 405 |
| Chain | Residue | Details |
| A | ARG54 | electrostatic stabiliser |
| A | THR55 | electrostatic stabiliser, increase electrophilicity |
| A | LYS84 | proton shuttle (general acid/base) |
| A | ARG105 | electrostatic stabiliser, increase electrophilicity |
| A | HIS134 | electrostatic stabiliser, increase electrophilicity |
