Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6KF4

Cryo-EM structure of Thermococcus kodakarensis RNA polymerase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0006354	biological_process	DNA-templated transcription elongation
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0006351	biological_process	DNA-templated transcription
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005737	cellular_component	cytoplasm
D	0006351	biological_process	DNA-templated transcription
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046983	molecular_function	protein dimerization activity
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005737	cellular_component	cytoplasm
E	0006351	biological_process	DNA-templated transcription
E	0006352	biological_process	DNA-templated transcription initiation
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
F	0000166	molecular_function	nucleotide binding
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0006352	biological_process	DNA-templated transcription initiation
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0030880	cellular_component	RNA polymerase complex
G	0003677	molecular_function	DNA binding
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005737	cellular_component	cytoplasm
H	0006351	biological_process	DNA-templated transcription
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0034062	molecular_function	5'-3' RNA polymerase activity
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0006351	biological_process	DNA-templated transcription
K	0016740	molecular_function	transferase activity
K	0016779	molecular_function	nucleotidyltransferase activity
K	0034062	molecular_function	5'-3' RNA polymerase activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005737	cellular_component	cytoplasm
L	0006351	biological_process	DNA-templated transcription
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0046983	molecular_function	protein dimerization activity
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed RNA polymerase activity
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0006351	biological_process	DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0034062	molecular_function	5'-3' RNA polymerase activity
N	0046872	molecular_function	metal ion binding
P	0000428	cellular_component	DNA-directed RNA polymerase complex
P	0003677	molecular_function	DNA binding
P	0003899	molecular_function	DNA-directed RNA polymerase activity
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0006351	biological_process	DNA-templated transcription
P	0008270	molecular_function	zinc ion binding
P	0016740	molecular_function	transferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0034062	molecular_function	5'-3' RNA polymerase activity
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 1001

Chain	Residue
A	ASP461
A	ASP463
A	ASP465

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS60
A	GLU61
A	CYS63
A	CYS70
A	HIS73

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1003

Chain	Residue
A	CYS147
A	HIS149
A	CYS150
A	CYS103

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 1201

Chain	Residue
B	CYS1065
B	CYS1068
B	CYS1083
B	CYS1086

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN N 1401

Chain	Residue
N	CYS7
N	CYS10
N	CYS44
N	CYS45

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN P 1501

Chain	Residue
P	CYS11
P	GLY12
P	GLU14
P	CYS27
P	CYS30

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN G 201

Chain	Residue
G	CYS117
G	GLY118
G	THR119
G	HIS122
G	CYS140
G	LYS142

Functional Information from PROSITE/UniProt

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NALRRtilsevptfAvdeVefleNdSalfDEiIAhRLAMIP

Chain	Residue	Details
D	ASN27-PRO67

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HVLVPEHriLseEE

Chain	Residue	Details
H	HIS12-GLU25

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TrFEkARiIGaRAlQ

Chain	Residue	Details
K	THR5-GLN19

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFTCG

Chain	Residue	Details
N	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. LegEdHTFaNlLtetLhenehVtfagYtieHP

Chain	Residue	Details
L	LEU17-PRO48

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGV

Chain	Residue	Details
B	GLY879-VAL891

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00250","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	83
Details	Domain: {"description":"HTH TFE/IIEalpha-type","evidences":[{"source":"HAMAP-Rule","id":"MF_01909","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)