6KEZ
Crystal structure of GAPDH/CP12/PRK complex from Arabidopsis thaliana
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
| E | 0006006 | biological_process | glucose metabolic process |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0050661 | molecular_function | NADP binding |
| E | 0051287 | molecular_function | NAD binding |
| F | 0006006 | biological_process | glucose metabolic process |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0050661 | molecular_function | NADP binding |
| F | 0051287 | molecular_function | NAD binding |
| G | 0006006 | biological_process | glucose metabolic process |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0050661 | molecular_function | NADP binding |
| G | 0051287 | molecular_function | NAD binding |
| H | 0006006 | biological_process | glucose metabolic process |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0050661 | molecular_function | NADP binding |
| H | 0051287 | molecular_function | NAD binding |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005975 | biological_process | carbohydrate metabolic process |
| I | 0008974 | molecular_function | phosphoribulokinase activity |
| I | 0016301 | molecular_function | kinase activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005975 | biological_process | carbohydrate metabolic process |
| J | 0008974 | molecular_function | phosphoribulokinase activity |
| J | 0016301 | molecular_function | kinase activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005975 | biological_process | carbohydrate metabolic process |
| K | 0008974 | molecular_function | phosphoribulokinase activity |
| K | 0016301 | molecular_function | kinase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0005975 | biological_process | carbohydrate metabolic process |
| L | 0008974 | molecular_function | phosphoribulokinase activity |
| L | 0016301 | molecular_function | kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | ASN7 |
| A | GLY98 |
| A | THR99 |
| A | GLY100 |
| A | THR122 |
| A | CYS153 |
| A | ASN316 |
| A | GLU317 |
| A | TYR320 |
| P | GLU69 |
| P | TYR76 |
| A | PHE9 |
| P | ASN78 |
| A | GLY10 |
| A | ARG11 |
| A | ILE12 |
| A | ASN34 |
| A | ASP35 |
| A | THR36 |
| A | ARG80 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | PHE9 |
| B | GLY10 |
| B | ARG11 |
| B | ILE12 |
| B | ASP35 |
| B | THR36 |
| B | ARG80 |
| B | GLY98 |
| B | GLY100 |
| B | THR122 |
| B | ALA123 |
| B | CYS153 |
| B | ASN316 |
| B | TYR320 |
| G | PHE254 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | PHE9 |
| C | GLY10 |
| C | ARG11 |
| C | ILE12 |
| C | ASP35 |
| C | THR36 |
| C | GLY98 |
| C | THR99 |
| C | GLY100 |
| C | ALA123 |
| C | CYS153 |
| C | THR183 |
| C | ASN316 |
| C | GLU317 |
| C | TYR320 |
| O | GLU69 |
| O | TYR76 |
| O | ASN78 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue NAD D 401 |
| Chain | Residue |
| A | SER192 |
| D | ASN7 |
| D | GLY10 |
| D | ARG11 |
| D | ILE12 |
| D | ASP35 |
| D | THR36 |
| D | ARG80 |
| D | GLY100 |
| D | THR122 |
| D | ALA123 |
| D | SER152 |
| D | ASN316 |
| D | TYR320 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue NAD E 401 |
| Chain | Residue |
| E | ASN7 |
| E | ARG11 |
| E | ILE12 |
| E | ASP35 |
| E | THR36 |
| E | ARG80 |
| E | THR99 |
| E | GLY100 |
| E | THR122 |
| E | ALA123 |
| E | CYS153 |
| E | THR183 |
| E | ASN316 |
| E | TYR320 |
| E | HOH502 |
| H | SER192 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue NAD F 401 |
| Chain | Residue |
| N | ASN78 |
| F | ASN7 |
| F | GLY10 |
| F | ARG11 |
| F | ILE12 |
| F | ASN34 |
| F | ASP35 |
| F | THR36 |
| F | GLY98 |
| F | THR99 |
| F | GLY100 |
| F | THR122 |
| F | CYS153 |
| F | THR183 |
| F | ASN316 |
| F | TYR320 |
| N | TYR76 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue NAD G 401 |
| Chain | Residue |
| B | PHE254 |
| G | ASN7 |
| G | GLY10 |
| G | ARG11 |
| G | ILE12 |
| G | ASP35 |
| G | ARG80 |
| G | GLY98 |
| G | GLY100 |
| G | THR122 |
| G | ALA123 |
| G | CYS153 |
| G | HIS180 |
| G | THR183 |
| G | ASN316 |
| G | TYR320 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | binding site for residue NAD H 401 |
| Chain | Residue |
| H | ASN7 |
| H | GLY10 |
| H | ARG11 |
| H | ILE12 |
| H | ASN34 |
| H | ASP35 |
| H | THR36 |
| H | ARG80 |
| H | GLY98 |
| H | THR99 |
| H | GLY100 |
| H | THR122 |
| H | ALA123 |
| H | CYS153 |
| H | ASN316 |
| H | GLU317 |
| M | GLU69 |
| M | TYR76 |
| M | ASN78 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10009","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20516587","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22514274","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Site: {"description":"Activates thiol group during catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 136 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 104 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
