6KEP
Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in 17beta-estradiol- and glutathione-bound form
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AA | 0003824 | molecular_function | catalytic activity |
| AA | 0004364 | molecular_function | glutathione transferase activity |
| AA | 0004769 | molecular_function | steroid Delta-isomerase activity |
| AA | 0005737 | cellular_component | cytoplasm |
| AA | 0006629 | biological_process | lipid metabolic process |
| AA | 0006694 | biological_process | steroid biosynthetic process |
| AA | 0006749 | biological_process | glutathione metabolic process |
| AA | 0009636 | biological_process | response to toxic substance |
| AA | 0016740 | molecular_function | transferase activity |
| AA | 0042632 | biological_process | cholesterol homeostasis |
| AA | 0045456 | biological_process | ecdysteroid biosynthetic process |
| BA | 0003824 | molecular_function | catalytic activity |
| BA | 0004364 | molecular_function | glutathione transferase activity |
| BA | 0004769 | molecular_function | steroid Delta-isomerase activity |
| BA | 0005737 | cellular_component | cytoplasm |
| BA | 0006629 | biological_process | lipid metabolic process |
| BA | 0006694 | biological_process | steroid biosynthetic process |
| BA | 0006749 | biological_process | glutathione metabolic process |
| BA | 0009636 | biological_process | response to toxic substance |
| BA | 0016740 | molecular_function | transferase activity |
| BA | 0042632 | biological_process | cholesterol homeostasis |
| BA | 0045456 | biological_process | ecdysteroid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue GSH AA 301 |
| Chain | Residue |
| AA | SER14 |
| AA | HIS71 |
| AA | PHE110 |
| AA | HOH464 |
| AA | HOH468 |
| AA | HOH470 |
| AA | HOH486 |
| AA | HOH526 |
| AA | HOH539 |
| AA | HOH573 |
| BA | SER107 |
| AA | LEU38 |
| AA | GLN43 |
| AA | HIS55 |
| AA | SER56 |
| AA | VAL57 |
| AA | PRO58 |
| AA | ASP69 |
| AA | SER70 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue EST AA 302 |
| Chain | Residue |
| AA | PRO15 |
| AA | LEU38 |
| AA | PHE39 |
| AA | ASP113 |
| AA | SER114 |
| AA | SER118 |
| AA | ARG122 |
| AA | THR172 |
| AA | HOH504 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue GSH BA 301 |
| Chain | Residue |
| AA | SER107 |
| BA | SER14 |
| BA | LEU38 |
| BA | GLN43 |
| BA | HIS55 |
| BA | SER56 |
| BA | VAL57 |
| BA | PRO58 |
| BA | ASP69 |
| BA | SER70 |
| BA | HIS71 |
| BA | PHE110 |
| BA | HOH423 |
| BA | HOH429 |
| BA | HOH454 |
| BA | HOH480 |
| BA | HOH483 |
| BA | HOH534 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EST BA 302 |
| Chain | Residue |
| BA | PRO15 |
| BA | PHE39 |
| BA | ASP113 |
| BA | SER114 |
| BA | SER118 |
| BA | THR172 |
| BA | HOH505 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 162 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 254 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
