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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6KC6

HOIP-HOIPIN8 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0008270	molecular_function	zinc ion binding
A	0071797	cellular_component	LUBAC complex
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0008270	molecular_function	zinc ion binding
C	0071797	cellular_component	LUBAC complex
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0008270	molecular_function	zinc ion binding
E	0071797	cellular_component	LUBAC complex
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0008270	molecular_function	zinc ion binding
G	0071797	cellular_component	LUBAC complex
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0008270	molecular_function	zinc ion binding
I	0071797	cellular_component	LUBAC complex
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0008270	molecular_function	zinc ion binding
K	0071797	cellular_component	LUBAC complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1101

Chain	Residue
A	CYS871
A	CYS874
A	CYS890
A	CYS893

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1102

Chain	Residue
A	CYS898
A	CYS901
A	HIS926
A	CYS930

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1103

Chain	Residue
A	CYS916
A	HIS923
A	HIS925
A	CYS911

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1104

Chain	Residue
A	CYS969
A	CYS986
A	CYS998
A	HIS1001

site_id	AC5
Number of Residues	10
Details	binding site for residue D60 A 1105

Chain	Residue
A	GLY884
A	CYS885
A	MET886
A	HIS887
A	LEU922
A	PHE932
A	ARG935
A	ASP936
A	HOH1210
I	D601105

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 1106

Chain	Residue
A	TYR1021
A	ARG1032

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 1107

Chain	Residue
A	ASN903
A	GLN1065
C	LEU1041

site_id	AC8
Number of Residues	1
Details	binding site for residue CL A 1108

Chain	Residue
A	LYS988

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL A 1109

Chain	Residue
A	GLY884
A	ARG935
A	ALA1000

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL A 1110

Chain	Residue
A	LEU1009
A	HIS1013
A	ARG1070
A	HOH1202
I	GLN947

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 1101

Chain	Residue
C	CYS871
C	CYS874
C	CYS890
C	CYS893

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 1102

Chain	Residue
C	CYS898
C	CYS901
C	HIS926
C	CYS930

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN C 1103

Chain	Residue
C	CYS911
C	CYS916
C	HIS923
C	HIS925

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN C 1104

Chain	Residue
C	CYS969
C	CYS986
C	CYS998
C	HIS1001

site_id	AD6
Number of Residues	2
Details	binding site for residue CL C 1106

Chain	Residue
C	TYR1021
C	ARG1032

site_id	AD7
Number of Residues	4
Details	binding site for residue GOL C 1107

Chain	Residue
C	GLY884
C	ARG935
C	ALA1000
C	GLU1004

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL C 1108

Chain	Residue
C	GLY883
C	LYS988
C	HOH1226
K	D601105
K	HOH1203

site_id	AD9
Number of Residues	3
Details	binding site for residue GOL C 1109

Chain	Residue
C	ASN954
C	ARG970
C	TYR1005

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN E 1101

Chain	Residue
E	CYS871
E	CYS874
E	CYS890
E	CYS893

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN E 1102

Chain	Residue
E	CYS898
E	CYS901
E	HIS926
E	CYS930

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN E 1103

Chain	Residue
E	CYS911
E	CYS916
E	HIS923
E	HIS925

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN E 1104

Chain	Residue
E	CYS969
E	CYS986
E	CYS998
E	HIS1001

site_id	AE5
Number of Residues	3
Details	binding site for residue CL E 1106

Chain	Residue
E	TYR1021
E	ALA1029
E	ARG1032

site_id	AE6
Number of Residues	4
Details	binding site for residue GOL E 1107

Chain	Residue
E	GLY884
E	ARG935
E	ALA1000
E	GLU1004

site_id	AE7
Number of Residues	4
Details	binding site for residue GOL E 1108

Chain	Residue
E	LEU922
E	LYS988
E	D601105
E	HOH1209

site_id	AE8
Number of Residues	4
Details	binding site for residue ZN G 1101

Chain	Residue
G	CYS890
G	CYS893
G	CYS871
G	CYS874

site_id	AE9
Number of Residues	4
Details	binding site for residue ZN G 1102

Chain	Residue
G	CYS898
G	CYS901
G	HIS926
G	CYS930

site_id	AF1
Number of Residues	4
Details	binding site for residue ZN G 1103

Chain	Residue
G	CYS911
G	CYS916
G	HIS923
G	HIS925

site_id	AF2
Number of Residues	4
Details	binding site for residue ZN G 1104

Chain	Residue
G	CYS969
G	CYS986
G	CYS998
G	HIS1001

site_id	AF3
Number of Residues	2
Details	binding site for residue CL G 1106

Chain	Residue
G	TYR1021
G	ARG1032

site_id	AF4
Number of Residues	4
Details	binding site for residue GOL G 1107

Chain	Residue
G	GLY884
G	ARG935
G	ALA1000
G	GLU1004

site_id	AF5
Number of Residues	4
Details	binding site for residue ZN I 1101

Chain	Residue
I	CYS871
I	CYS874
I	CYS890
I	CYS893

site_id	AF6
Number of Residues	4
Details	binding site for residue ZN I 1102

Chain	Residue
I	CYS898
I	CYS901
I	HIS926
I	CYS930

site_id	AF7
Number of Residues	4
Details	binding site for residue ZN I 1103

Chain	Residue
I	CYS911
I	CYS916
I	HIS923
I	HIS925

site_id	AF8
Number of Residues	4
Details	binding site for residue ZN I 1104

Chain	Residue
I	CYS969
I	CYS986
I	CYS998
I	HIS1001

site_id	AF9
Number of Residues	2
Details	binding site for residue CL I 1106

Chain	Residue
I	TYR1021
I	ARG1032

site_id	AG1
Number of Residues	1
Details	binding site for residue CL I 1107

Chain	Residue
I	LYS988

site_id	AG2
Number of Residues	4
Details	binding site for residue ZN K 1101

Chain	Residue
K	CYS871
K	CYS874
K	CYS890
K	CYS893

site_id	AG3
Number of Residues	4
Details	binding site for residue ZN K 1102

Chain	Residue
K	CYS898
K	CYS901
K	HIS926
K	CYS930

site_id	AG4
Number of Residues	4
Details	binding site for residue ZN K 1103

Chain	Residue
K	CYS911
K	CYS916
K	HIS923
K	HIS925

site_id	AG5
Number of Residues	4
Details	binding site for residue ZN K 1104

Chain	Residue
K	CYS969
K	CYS986
K	CYS998
K	HIS1001

site_id	AG6
Number of Residues	2
Details	binding site for residue CL K 1106

Chain	Residue
K	TYR1021
K	ARG1032

site_id	AG7
Number of Residues	4
Details	binding site for residue GOL K 1107

Chain	Residue
C	LEU922
C	D601105
C	HOH1208
K	LYS988

site_id	AG8
Number of Residues	5
Details	binding site for residue GOL K 1108

Chain	Residue
E	LYS1056
E	GLU1060
K	ASP870
K	PRO872
K	SER1066

site_id	AG9
Number of Residues	14
Details	binding site for Di-peptide D60 C 1105 and CYS C 885

Chain	Residue
C	ARG882
C	GLY883
C	GLY884
C	MET886
C	HIS887
C	PHE905
C	LEU922
C	PHE932
C	ARG935
C	ASP936
C	HOH1208
C	HOH1211
K	D601105
K	GOL1107

site_id	AH1
Number of Residues	8
Details	binding site for Di-peptide D60 E 1105 and CYS E 885

Chain	Residue
E	ARG882
E	GLY883
E	GLY884
E	MET886
E	HIS887
E	ARG935
E	ASP936
E	GOL1108

site_id	AH2
Number of Residues	9
Details	binding site for Di-peptide D60 G 1105 and CYS G 885

Chain	Residue
G	ARG882
G	GLY883
G	GLY884
G	MET886
G	HIS887
G	LEU922
G	ARG935
G	ASP936
G	HOH1206

site_id	AH3
Number of Residues	12
Details	binding site for Di-peptide D60 I 1105 and CYS I 885

Chain	Residue
A	GLY883
A	D601105
I	ARG882
I	GLY883
I	GLY884
I	MET886
I	HIS887
I	LEU922
I	ARG935
I	ASP936
I	HOH1209
I	HOH1229

site_id	AH4
Number of Residues	14
Details	binding site for Di-peptide D60 K 1105 and CYS K 885

Chain	Residue
C	GLY883
C	D601105
C	GOL1108
K	ARG882
K	GLY883
K	GLY884
K	MET886
K	HIS887
K	PHE905
K	LEU922
K	PHE932
K	ARG935
K	ASP936
K	HOH1203

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CrHqFCsgCY

Chain	Residue	Details
A	CYS893-TYR902

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Zinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27572974","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

247536

PDB entries from 2026-01-14

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