6KB6

X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA) co-crystals obtained by delipidation and cross-seeding

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 501

Chain	Residue
A	LYS222
A	ARG226
A	LEU229
A	SER323
A	MET325
A	ASN326
A	ASN366

---

site_id	AC2
Number of Residues	7
Details	binding site for residue T4T A 502

Chain	Residue
A	TYR314
A	VAL332
A	HIS440
A	LEU460
A	TYR464
A	CYS276
A	SER280

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	227
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	129
Details	Region: {"description":"Required for heterodimerization with RXRA"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19116277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ET1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Essential for heterodimerization with RXRA"}

Chain

Residue

Details

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