6K9A
The complex of NrS-1 N terminal domain (1-305) with dGTP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ASP78 |
| A | ASP80 |
| A | DGT403 |
| A | HOH538 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 402 |
| Chain | Residue |
| A | THR69 |
| A | ASP72 |
| A | PHE74 |
| A | GLU142 |
| A | HOH520 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue DGT A 403 |
| Chain | Residue |
| A | THR26 |
| A | LYS27 |
| A | ILE28 |
| A | ASP78 |
| A | ASP80 |
| A | SER108 |
| A | PRO109 |
| A | SER110 |
| A | HIS115 |
| A | ARG145 |
| A | TYR146 |
| A | MET147 |
| A | THR148 |
| A | CA401 |
| A | HOH504 |
| A | HOH509 |
| A | HOH515 |
| A | HOH516 |
| A | HOH541 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: For polymerase activity => ECO:0000269|PubMed:28265063 |
| Chain | Residue | Details |
| A | ASP78 | |
| A | ASP80 | |
| A | HIS115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: For polymerase and primase activities => ECO:0000269|PubMed:30739783 |
| Chain | Residue | Details |
| A | GLU139 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31176489, ECO:0000269|PubMed:34975792 |
| Chain | Residue | Details |
| A | ASP78 | |
| A | ASP80 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:31176489 |
| Chain | Residue | Details |
| A | SER108 | |
| A | HIS115 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30739783 |
| Chain | Residue | Details |
| A | GLU304 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Involved in primer extension => ECO:0000269|PubMed:31176489 |
| Chain | Residue | Details |
| A | ARG145 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Involved in sugar discrimination to select deoxynucleotides => ECO:0000269|PubMed:31176489 |
| Chain | Residue | Details |
| A | TYR146 |
