6K8K

Crystal structure of Arabidopsis thaliana BIC2-CRY2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000325	cellular_component	plant-type vacuole
A	0003677	molecular_function	DNA binding
A	0003904	molecular_function	deoxyribodipyrimidine photo-lyase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006952	biological_process	defense response
A	0007623	biological_process	circadian rhythm
A	0009414	biological_process	response to water deprivation
A	0009416	biological_process	response to light stimulus
A	0009637	biological_process	response to blue light
A	0009638	biological_process	phototropism
A	0009646	biological_process	response to absence of light
A	0009785	biological_process	blue light signaling pathway
A	0009791	biological_process	post-embryonic development
A	0009881	molecular_function	photoreceptor activity
A	0009882	molecular_function	blue light photoreceptor activity
A	0009909	biological_process	regulation of flower development
A	0009911	biological_process	positive regulation of flower development
A	0010075	biological_process	regulation of meristem growth
A	0010118	biological_process	stomatal movement
A	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
A	0010617	biological_process	circadian regulation of calcium ion oscillation
A	0016301	molecular_function	kinase activity
A	0016604	cellular_component	nuclear body
A	0032922	biological_process	circadian regulation of gene expression
A	0042752	biological_process	regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0046777	biological_process	protein autophosphorylation
A	0046872	molecular_function	metal ion binding
A	0048574	biological_process	long-day photoperiodism, flowering
A	0048580	biological_process	regulation of post-embryonic development
A	0048731	biological_process	system development
A	0051607	biological_process	defense response to virus
A	0071949	molecular_function	FAD binding
A	0072387	biological_process	flavin adenine dinucleotide metabolic process
A	1901371	biological_process	regulation of leaf morphogenesis
A	1902347	biological_process	response to strigolactone
A	2000028	biological_process	regulation of photoperiodism, flowering
A	2000377	biological_process	regulation of reactive oxygen species metabolic process
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
B	0000166	molecular_function	nucleotide binding
B	0000325	cellular_component	plant-type vacuole
B	0003677	molecular_function	DNA binding
B	0003904	molecular_function	deoxyribodipyrimidine photo-lyase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006952	biological_process	defense response
B	0007623	biological_process	circadian rhythm
B	0009414	biological_process	response to water deprivation
B	0009416	biological_process	response to light stimulus
B	0009637	biological_process	response to blue light
B	0009638	biological_process	phototropism
B	0009646	biological_process	response to absence of light
B	0009785	biological_process	blue light signaling pathway
B	0009791	biological_process	post-embryonic development
B	0009881	molecular_function	photoreceptor activity
B	0009882	molecular_function	blue light photoreceptor activity
B	0009909	biological_process	regulation of flower development
B	0009911	biological_process	positive regulation of flower development
B	0010075	biological_process	regulation of meristem growth
B	0010118	biological_process	stomatal movement
B	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
B	0010617	biological_process	circadian regulation of calcium ion oscillation
B	0016301	molecular_function	kinase activity
B	0016604	cellular_component	nuclear body
B	0032922	biological_process	circadian regulation of gene expression
B	0042752	biological_process	regulation of circadian rhythm
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043153	biological_process	entrainment of circadian clock by photoperiod
B	0046777	biological_process	protein autophosphorylation
B	0046872	molecular_function	metal ion binding
B	0048574	biological_process	long-day photoperiodism, flowering
B	0048580	biological_process	regulation of post-embryonic development
B	0048731	biological_process	system development
B	0051607	biological_process	defense response to virus
B	0071949	molecular_function	FAD binding
B	0072387	biological_process	flavin adenine dinucleotide metabolic process
B	1901371	biological_process	regulation of leaf morphogenesis
B	1902347	biological_process	response to strigolactone
B	2000028	biological_process	regulation of photoperiodism, flowering
B	2000377	biological_process	regulation of reactive oxygen species metabolic process
B	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	0009785	biological_process	blue light signaling pathway
D	0000166	molecular_function	nucleotide binding
D	0000325	cellular_component	plant-type vacuole
D	0003677	molecular_function	DNA binding
D	0003904	molecular_function	deoxyribodipyrimidine photo-lyase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006952	biological_process	defense response
D	0007623	biological_process	circadian rhythm
D	0009414	biological_process	response to water deprivation
D	0009416	biological_process	response to light stimulus
D	0009637	biological_process	response to blue light
D	0009638	biological_process	phototropism
D	0009646	biological_process	response to absence of light
D	0009785	biological_process	blue light signaling pathway
D	0009791	biological_process	post-embryonic development
D	0009881	molecular_function	photoreceptor activity
D	0009882	molecular_function	blue light photoreceptor activity
D	0009909	biological_process	regulation of flower development
D	0009911	biological_process	positive regulation of flower development
D	0010075	biological_process	regulation of meristem growth
D	0010118	biological_process	stomatal movement
D	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
D	0010617	biological_process	circadian regulation of calcium ion oscillation
D	0016301	molecular_function	kinase activity
D	0016604	cellular_component	nuclear body
D	0032922	biological_process	circadian regulation of gene expression
D	0042752	biological_process	regulation of circadian rhythm
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043153	biological_process	entrainment of circadian clock by photoperiod
D	0046777	biological_process	protein autophosphorylation
D	0046872	molecular_function	metal ion binding
D	0048574	biological_process	long-day photoperiodism, flowering
D	0048580	biological_process	regulation of post-embryonic development
D	0048731	biological_process	system development
D	0051607	biological_process	defense response to virus
D	0071949	molecular_function	FAD binding
D	0072387	biological_process	flavin adenine dinucleotide metabolic process
D	1901371	biological_process	regulation of leaf morphogenesis
D	1902347	biological_process	response to strigolactone
D	2000028	biological_process	regulation of photoperiodism, flowering
D	2000377	biological_process	regulation of reactive oxygen species metabolic process
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
E	0009785	biological_process	blue light signaling pathway
F	0009785	biological_process	blue light signaling pathway
G	0000166	molecular_function	nucleotide binding
G	0000325	cellular_component	plant-type vacuole
G	0003677	molecular_function	DNA binding
G	0003904	molecular_function	deoxyribodipyrimidine photo-lyase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006325	biological_process	chromatin organization
G	0006338	biological_process	chromatin remodeling
G	0006952	biological_process	defense response
G	0007623	biological_process	circadian rhythm
G	0009414	biological_process	response to water deprivation
G	0009416	biological_process	response to light stimulus
G	0009637	biological_process	response to blue light
G	0009638	biological_process	phototropism
G	0009646	biological_process	response to absence of light
G	0009785	biological_process	blue light signaling pathway
G	0009791	biological_process	post-embryonic development
G	0009881	molecular_function	photoreceptor activity
G	0009882	molecular_function	blue light photoreceptor activity
G	0009909	biological_process	regulation of flower development
G	0009911	biological_process	positive regulation of flower development
G	0010075	biological_process	regulation of meristem growth
G	0010118	biological_process	stomatal movement
G	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
G	0010617	biological_process	circadian regulation of calcium ion oscillation
G	0016301	molecular_function	kinase activity
G	0016604	cellular_component	nuclear body
G	0032922	biological_process	circadian regulation of gene expression
G	0042752	biological_process	regulation of circadian rhythm
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043153	biological_process	entrainment of circadian clock by photoperiod
G	0046777	biological_process	protein autophosphorylation
G	0046872	molecular_function	metal ion binding
G	0048574	biological_process	long-day photoperiodism, flowering
G	0048580	biological_process	regulation of post-embryonic development
G	0048731	biological_process	system development
G	0051607	biological_process	defense response to virus
G	0071949	molecular_function	FAD binding
G	0072387	biological_process	flavin adenine dinucleotide metabolic process
G	1901371	biological_process	regulation of leaf morphogenesis
G	1902347	biological_process	response to strigolactone
G	2000028	biological_process	regulation of photoperiodism, flowering
G	2000377	biological_process	regulation of reactive oxygen species metabolic process
G	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
H	0009785	biological_process	blue light signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue FAD A 701

Chain	Residue
A	TYR232
A	LEU293
A	ARG294
A	TRP353
A	ASN356
A	ARG359
A	VAL360
A	ASP387
A	ALA388
A	ASP389
A	CYS392
A	THR244
A	ASP393
A	GLY396
A	MG703
A	HOH815
A	SER245
A	LEU246
A	LEU247
A	SER248
A	LEU251
A	GLY290
A	ILE291

---

site_id	AC2
Number of Residues	6
Details	binding site for residue AMP A 702

Chain	Residue
A	PHE151
A	ASN356
A	ARG357
A	VAL360
A	LEU395
A	TYR399

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 703

Chain	Residue
A	THR244
A	ASN356
A	FAD701

---

site_id	AC4
Number of Residues	24
Details	binding site for residue FAD B 701

Chain	Residue
B	TYR232
B	THR244
B	SER245
B	LEU246
B	LEU247
B	SER248
B	LEU251
B	PHE287
B	GLY290
B	ILE291
B	LEU293
B	ARG294
B	TRP353
B	MET354
B	ASN356
B	ARG359
B	VAL360
B	ASP387
B	ALA388
B	ASP389
B	CYS392
B	ASP393
B	GLY396
B	AMP702

---

site_id	AC5
Number of Residues	9
Details	binding site for residue AMP B 702

Chain	Residue
B	PHE151
B	LEU293
B	ASN356
B	ARG357
B	VAL360
B	LEU395
B	TYR399
B	ILE404
B	FAD701

---

site_id	AC6
Number of Residues	26
Details	binding site for residue FAD D 701

Chain	Residue
D	TYR232
D	THR244
D	SER245
D	LEU246
D	LEU247
D	SER248
D	LEU251
D	PHE287
D	GLY290
D	ILE291
D	LEU293
D	ARG294
D	TRP353
D	MET354
D	ASN356
D	ARG359
D	VAL360
D	SER363
D	ASP387
D	ALA388
D	ASP389
D	CYS392
D	ASP393
D	GLY396
D	HOH814
D	HOH837

---

site_id	AC7
Number of Residues	11
Details	binding site for residue AMP D 702

Chain	Residue
D	ILE404
D	ASP406
D	MG704
D	PHE151
D	ARG289
D	LEU293
D	ASN356
D	ARG357
D	VAL360
D	LEU395
D	TYR399

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG D 703

Chain	Residue
D	GLU347
D	THR351
F	ARG48

---

site_id	AC9
Number of Residues	3
Details	binding site for residue MG D 704

Chain	Residue
D	TYR399
D	HIS408
D	AMP702

---

site_id	AD1
Number of Residues	25
Details	binding site for residue FAD G 701

Chain	Residue
G	TYR232
G	THR244
G	SER245
G	LEU246
G	LEU247
G	SER248
G	LEU251
G	PHE287
G	GLY290
G	ILE291
G	LEU293
G	ARG294
G	TRP353
G	MET354
G	ASN356
G	ARG359
G	VAL360
G	ASP387
G	ALA388
G	ASP389
G	CYS392
G	ASP393
G	GLY396
G	AMP702
G	MG703

---

site_id	AD2
Number of Residues	11
Details	binding site for residue AMP G 702

Chain	Residue
G	PHE151
G	LYS237
G	LEU293
G	ASN356
G	ARG357
G	VAL360
G	LEU395
G	TYR399
G	ILE404
G	FAD701
G	HOH807

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MG G 703

Chain	Residue
G	THR244
G	HIS355
G	ASN356
G	FAD701

---

Functional Information from PROSITE/UniProt

site_id	PS00394
Number of Residues	13
Details	DNA_PHOTOLYASES_1_1 DNA photolyases class 1 signature 1. TGyPLVDAgMReL

Chain	Residue	Details
A	THR336-LEU348

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	516
Details	Domain: {"description":"Photolyase/cryptochrome alpha/beta","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32398826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K8K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q43125","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32398826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K8K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Site: {"description":"Involved in electron transfer from the protein surface to the FAD cofactor","evidences":[{"source":"PubMed","id":"25428980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---